Abstract
1. Central serotonergic dysfunction and genetic factors are associated with suicidal behavior in psychiatric patients. The goal of this study was to examine the association between the 5-HT2A gene polymorphism (102T/C) and suicide in a sample of Brazilian psychiatric inpatients.
2. We studied 225 subjects. Genotypic frequencies were obtained after DNA extraction and the region of 5-HT2A/T102C containing the polymorphic site amplified by the polymerase chain reaction and digested with the restriction enzyme HpaII.
3. No differences were found between patients with and without suicide attempt history. Patients with a history of severe suicide attempts also did not exhibit different genotypic frequencies when compared with patients without a suicide attempt history.
4. These results suggest that the 5HT2A gene polymorphism (102T/C) may not be involved in the genetic susceptibility to suicidal behavior.
This is a preview of subscription content, log in via an institution to check access.
REFERENCES
Asberg,M. (1997). Neurotransmitters and suicidal behavior. The evidence from cerebrospinal fluid study. Ann. N.Y. Acad. Sci. 836:158–181.
Arango,V., Underwood, M.D., and Mann, J. J. (1997). Postmorten findings in suicide victims: Implications for in vivo imaging studies. Ann. N.Y. Acad. Sci. 836:269–287.
Correa, H., Duval, F., Mokrani, M. C., Bailey, P., Tremeau, F., Staner, L., Diep, T. S., Crocq, M. A., and Macher, J. P. (2002). Serotonergic function and suicidal behavior in schizophrenia. Schizophrenia Res. 56:75–85.
Correa, H., Duval, F., Mokrani, M.C., Bailey, P., Tremeau, F., Staner, L., Diep, T. S., Hode,Y., Crocq, M. A., and Macher, J. P. (2000). Prolactin response to D-fenfluramine and suicidal behavior in depressed patients. Psychiatry Res. 93:189–199.
Diekstra, R. F.W. (1996). Epidemiologie du suicide. L'Encephale: Sp IV, 15–18.
Du, L., Bakish,D., Lapierre, Y.D., Ravindran, A.V., and Hrdina, P.D. (2000). Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. Am. J. Med. Genet. 96:56–60.
Goodal E. M., Cowen, J., Franklin, M., and Silverstone, T. (1993). Ritanserin attenuates anorectic, endocrine and thermic responses to D-fenfluramine in human volunteers. Psychopharmacoloy 112:461–466.
Mann, J. J. (1998). The neurobiology of suicide. Nat. Med. 4:25–30.
Ohara, K., Nagai, M., Tani, K., Tsukamoto, T., and Ohara, K. (1999). Schizophrenia and the serotonin-2A receptor promoter polymorphism. Psychiatry Res. 85:221–224.
Palazidou, E., Stephenson, T., Butler, J., Coskeran, P., Chambers, S., and McGregor, A. (1995). Evidence for 5-HT1A receptor involvement in the control of prolactin secretion in man. Psychopharmacology 119:311–314.
Pandey, G. N. (1997). Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies. Ann. N.Y. Acad. Sci. 836:182–183.
Roy, A. (1997). Genetics of suicides. Family studies and molecular genetics. Ann. N.Y. Acad. Sci. 836:135–157.
Turecki, G., Briere, R., Antonetti, T., Lesage, A. D., Seguin, M., Chaky, N., Vanier, C., Alda, M., Joober, R., Benkelfat, C., and Rouleau, G. A. (1999). Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmorten brain samples from subjects who did or did not commit suicide. Am. J. Psychiatry. 156:1456–1458.
Zhang, H. Y., Ishigaki, T., Tani, K., Chen, K., Shih, J. C., Miyasato, K., and Ohara, K. (1997). Serotonin 2A receptor gene polymorphism in mood disorders. Biol. Psychiatry 41:768–773.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Correa, H., De Marco, L., Boson, W. et al. Analysis of T102C 5HT2A Polymorphism in Brazilian Psychiatric Inpatients: Relationship with Suicidal Behavior. Cell Mol Neurobiol 22, 813–817 (2002). https://doi.org/10.1023/A:1021873411611
Issue Date:
DOI: https://doi.org/10.1023/A:1021873411611