Abstract
Genetic and environmental factors influence drug abuse, but abuse represents the culmination of a sequence of events. Different levels of use may have different determinants and these determinants may differ across drug types. Approximately 3200 male–male twin pairs from the Vietnam Era Twin Registry were interviewed by telephone. Data were obtained regarding exposure to six categories of illicit drugs, initiation of use, continuation of use, regular usage, and diagnosis of drug abuse/dependence. Genetic, common environmental, and unique environmental influences on transitions of drug involvement, defined as movement from one level of drug use to the next, were investigated. Marijuana had the highest conditional probability for the transition from exposure to use, from use to use more than five times, and from use more than five times to regular use. The rate of transition to regular use of heroin was higher than the rate for amphetamine, cocaine, sedatives, and psychedelics. Cocaine had the highest conditional probability for the transition from regular use to abuse/dependence. Significant genetic influences were observed for a number of transitions in marijuana, amphetamine, and cocaine usage.
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REFERENCES
American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd ed., rev., American Psychiatric Association, Washington, DC.
Brook, J. S. Brook, D. W., Gordon, A. S., Whiteman, M., and Cohen, P. (1990). The psychosocial etiology of adolescent drug use: A family interactional approach. Genet. Soc. Gen. Psychol. Monogr. 116
Brook J. S., Cohen, P., Whiteman, M., and Gordon, A. S. (1992). Psychosocial risk factors in the transition from moderate to heavy use or abuse of drugs. In Glantz, M., and Pickens, R. (eds.), Vulnerability to Drug Abuse, American Psychological Association, Washington, DC, pp. 359-388.
Brook, J. S., Whiteman, M., Cohen, P., Shapiro, J., and Balka, E. (1995). Longitudinally predicting late adolescent and young adult drug use: Childhood and adolescent precursors. J. Am. Acad. Child Adolesc. Psychiatry 34:1230-1238.
Cadoret, R. J. (1992). Genetic and environmental factors in initiation of drug use and the transition to abuse. In Glantz, M., and Pickens, R. (eds.), Vulnerability to Drug Abuse, American Psychological Association, Washington, DC, pp. 99-114.
Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G., and Steward, M. A. (1995). Adoption study demonstrating two genetic pathways to drug abuse. Arch. Gen. Psychiatry 52:42-52.
Czechowicz, D. (1988). Adolescent alcohol and drug abuse and its consequences—An overview, Am. J. Drug Alcohol Abuse 14:189-197.
Eisen, S., True, W., Goldberg, J., Henderson, W., and Robinette, D. (1987). The Vietnam Era Twin (VET) Registry: Method of construction. Acta. Genet. Med. Gemellol. 36:61-66.
Eisen, S., Neuman, R., Goldberg, J., Rice, J., and True, W. (1989). Determining zygosity in the Vietnam Era Twin Registry: An approach using questionnaires. Clin. Genet. 35:423-34.
Gfroerer, J. C., and Hughes, A. L. (1991). The feasibility of collecting drug abuse data by telephone. Public Health Rep. 106:394-383.
Henderson, W. G., Eisen, S., Goldberg, J., True, W. R., Barnes, J. E., and Vitek, M. E. (1990). The Vietnam Era Twin Registry: A resource for medical research. Public Health Rep. 105:368-373.
Joreskog, K. G., and Sorbom, D. (1988). LISREL 7: A Guide to the Program and Applications, Scientific Software, SPSS, Inc., Mooresville, IN.
Kandel, D. B., and Davies, M. (1992). Progression to regular marijuana involvement: Phenomenology and risk factors for near-daily use. In Glantz, M., and Pickens, R. (eds.), Vulnerability to Drug Abuse, American Psychological Association, Washington, DC, pp. 211-254.
Kendler, K. S., and Prescott, C. A. (1998). Cannabis use, abuse and dependence in a population-based sample of female twins. Am. J. Psychiatry 155:1016-1022.
Neale, M. C. (1997). Mx: Statistical Modeling 4th ed., Department of Psychiatry, Box 980126 VCU, Richmond, VA 23298.
Robins, L. N., Helzer, J. E., Cottler, I., and Goldring, E. (1989). National Institute of Mental Health Diagnostic Interview Schedule Version III revised, NIMH.
Rohde, P., Lewinsohn, P. M., and Seeley, J. R. (1997). Comparability of telephone and face-to-face interviews in assessing Axis I and Axis II disorders. Am. J. Psychiatry 154:1593-1598.
Sobin, C., Weissman, M. M., Goldstein, R., et al. (1993). Diagnostic interviewing for family studies: Comparing telephone and face-to-face methods for the diagnosis of lifetime psychiatric disorders. Psychiatr. Gen. 3:227-233.
Tsuang, M. T., Lyons, M. J., Eisen, S. A., Goldberg, J., True, W., Lin, N., Meyer, J. M., Toomey, R., and Eaves, L. J., (1996). Genetic influences on abuse of illicit drugs: A study of 3,297 twin pairs. Am. J. Med. Genet. 67:473-477.
Warner, L. A., Kessler, R. C., Hughes, M., Anthony, J. C., and Nelson, C. B., (1995). Prevalence and correlates of drug use and dependence in the United States: Results from the national comorbidity survey. Arch. Gen. Psychiatry 52:219-229.
Werch, C., and DiClemente, C. (1994). A multi-component stage model for matching drug prevention strategies and messages to youth stage of use. Health Educ Res. 9:37-46.
Yamaguchi, K., and Kandel, D. B. (1984). Patterns of drug use from adolescence to young adulthood: III. Predictors of progression. Am. J. Public Health 74:673-681
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Tsuang, M.T., Lyons, M.J., Harley, R.M. et al. Genetic and Environmental Influences on Transitions in Drug Use. Behav Genet 29, 473–479 (1999). https://doi.org/10.1023/A:1021635223370
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DOI: https://doi.org/10.1023/A:1021635223370