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Synthesis of New Sulfonamide Inhibitors of Carbonic Anhydrase

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Abstract

Four different derivatives of aromatic sulfonamides have been synthesized: 1,2-bis[(4-sulfonamidobenzamide)ethoxy]ethane (SBAM), 1,2-bis[(4-sulfonamidobenzoate)ethoxy]ethane, 1,2-bis[(2,4-dichloro-5-sulfonamidobenzamide)ethoxy]ethane, and 1,2-bis[(2,4-dichloro-5-sulfonamidobenzoate)ethoxy]ethane. SBAM is a most potent inhibitor on ciliary epithelium carbonic anhydrase and is approximately 13 times more active against carbonic anhydrase isoform II than against isoform I.

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Authors and Affiliations

  1. Faculty of Science and Art, Department of Chemistry, Balikesir University, 10100, Balikesir, Turkey

    O. Arslan, Ü. Çakir & H. I. Uğraş

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  1. O. Arslan
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  2. Ü. Çakir
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  3. H. I. Uğraş
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Correspondence to O. Arslan.

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Arslan, O., Çakir, Ü. & Uğraş, H.I. Synthesis of New Sulfonamide Inhibitors of Carbonic Anhydrase. Biochemistry (Moscow) 67, 1055–1057 (2002). https://doi.org/10.1023/A:1020538422592

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