Abstract
An increasing body of evidence supports theconcept of genetic heterogeneity within inflammatorybowel disease (IBD). In this study, a polymorphism ofthe motilin gene, which determines an amino acidsubstitution in the motilin protein, has been investigatedin IBD patients. Fifty patients with ulcerative colitis(UC), and 52 with Crohn's disease (CD) were investigatedfor anti-neutrophil cytoplasmatic antibodies (ANCA) and the polymorphism in the second exonof the motilin gene. Sixty unrelated blood donors servedas controls. ANCA were found in 30% of UC and 13% of CD.In controls the DNA polymorphism identified two alleles (1 and 2) at a frequency of 42% and58%, respectively. Patients with either UC or CD showeda slight increase in the frequency of allele 2 (69% and60%, respectively; P > 0.05 vs controls). This allele was predominant in ANCA-positive CDpatients (86%; P < 0.04) while in UC it did notdiffer. All ANCA-positive CD patients had the diseaseconfined to the colon. A polymorphism of second exon of the motilin gene, leading to a proteinvariant, is significantly more frequent in the subset ofANCA-positive CD patients. This subgroup of patientsappears to share peculiar genetic and clinical features.
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Annese, V., Piepoli, A., Andriulli, A. et al. Polymorphism of Motilin Gene in Patients with Crohn's Disease. Dig Dis Sci 43, 715–719 (1998). https://doi.org/10.1023/A:1018897510504
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DOI: https://doi.org/10.1023/A:1018897510504