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Enhanced Biliary Excretion of Lithocholate-3-Sulfate by Ursodeoxycholate-3,7-disulfate Infusion in Eisai Hyperbilirubinemic Rat (EHBR)

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Abstract

Biliary excretion of lithocholate-3-sulfate andursodeoxycholate 3,7-disulfate is markedly impaired inEHBR. In the present study, the effects ofursodeoxycholate 3,7-disulfate infusion onlithocholate-3-sulfate excretion were studied in EHBR andSprague-Dawley rats. Although in control rats,ursodeoxycholate 3,7-disulfate infusion had no effect onbiliary lithocholate-3-sulfate excretion, in EHBR itenhanced biliary lithocholate-3-sulfate excretion. Althoughursodeoxycholate 3,7-disulfate dose-dependentlyinhibited lithocholate-3-sulfate binding by rat serumalbumin and rat liver cytosol, it did not affect theserum clearance of lithocholate-3-sulfate in EHBR invivo. These findings indicate that in EHBR, in which themajor ATP-dependent organic anion transporter isimpaired, the excretory pathway for ursodeoxycholate 3,7-disulfate may interact to that forlithocholate-3-sulfate.

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Authors
  1. Hajime Takikawa
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  2. Naoyo Sano
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  3. Takashi Ogasawara
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  4. Masami Yamanaka
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Takikawa, H., Sano, N., Ogasawara, T. et al. Enhanced Biliary Excretion of Lithocholate-3-Sulfate by Ursodeoxycholate-3,7-disulfate Infusion in Eisai Hyperbilirubinemic Rat (EHBR). Dig Dis Sci 43, 188–192 (1998). https://doi.org/10.1023/A:1018809028425

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