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Thermal Stability of Mefruside–Polyvinylpyrrolidone Solid Dispersions

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Abstract

The stability of mefruside–polyvinylpyrrolidone (PVP) 30 solid dispersions at ratios of mefruside/PVP 30 of 9/1, 7/3, and 5/5 (g/g) after mechanical (tableting) and allothermic stressing (50, 60, and 70°C up to 240 hr) was investigated. Only the 5/5 (g/g) solid dispersion showed no recrystallization of mefruside, whereas a slight increase in crystallinity in the 7/3 (g/g) solid dispersion and a strong increase in the 9/1 (g/g) product were detected. The mechanisms of drug recrystallization in such “high-energy products” are discussed.

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Authors and Affiliations

  1. Center for Bio-Pharmaceutical Sciences, Division of Pharmaceutical Technology, Leiden University, Gorlaeus Laboratories, P.O. Box 9502, 2300, RA Leiden, The Netherlands

    Hans E. Junginger

  2. Institut für Pharmazeutische Technologic TU Braunschweig, Mendelssohnstr. 1, D-3300, Braunschweig, Federal Republic of Germany

    Michael Wedler

Authors
  1. Hans E. Junginger
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  2. Michael Wedler
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Junginger, H.E., Wedler, M. Thermal Stability of Mefruside–Polyvinylpyrrolidone Solid Dispersions. Pharm Res 3, 41–44 (1986). https://doi.org/10.1023/A:1016320831469

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  • DOI: https://doi.org/10.1023/A:1016320831469

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