Skip to main content
SpringerLink
Log in

Controlled Release of Polypeptides and Other Macromolecules

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

The use of polymeric matrices for the controlled release of polypeptides and other macromolecular drugs is reviewed. Three principal mechanisms of release include diffusion of the polypeptide through the polymer, erosion of the polymer matrix, and the application of magnetic fields to force more drug out of the matrix. The diffusion controlled systems generally utilize ethylene-vinyl acetate copolymer. The advantage of these systems is facile manipulation of the pore structure to obtain desired release kinetics. Release of many different polypeptides from these systems for periods of months has been demonstrated. Bioerosion provides the advantage that the polymer system does not need to be retrieved. Magnetism provides a mechanism whereby desired increases and decreases in polypeptide release rates can be achieved on demand.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Controlled Release of Biologically Active Agents (Tanquary, A. C., Lacey, R. E., ed.), Advances in Experimental Biology and Medicine, Vol. 47, Plenum, New York, 1974.

  2. Controlled Release Polymer Formulations (Paul, D. R., Harris, F. W., ed.), Amer. Chem. Soc. Symp. Ser. 33, Washington DC, 1976.

  3. Langer, R. (1980) Chem. Eng. Commun. 6, 1–48.

    Google Scholar 

  4. Langer, R. (1983) in: Bioavailability and the Pharmacokinetic Control of Drug Response (Smolen, V. R., ed.), J. Wiley and Sons, New York, in press.

    Google Scholar 

  5. Albisser, A. M., Spencer, W. J. (1982) IEEE Trans. Biomed. Eng. 4, 239–248.

    Google Scholar 

  6. Blackshear, P. J. (1979) Sci. Am. 241, 66–73.

    Google Scholar 

  7. Langer, R., Folkman, J. (1976) Nature 263, 797–800.

    Google Scholar 

  8. Rhine, W. D., Hsieh, D. S. T., Langer, R. (1980) J. Pharm. Sci. 69, 265–270.

    Google Scholar 

  9. Langer, R., Brem, H., Tapper, D. (1981) J. Biomed. Mat. Res. 15, 267–277.

    Google Scholar 

  10. Siegel, R. A., Cohen, J. M., Brown, L., Langer, R. (1983) in: Recent Advances in Drug Delivery Systems (Anderson, J., Kim, S., ed.), Plenum Press, New York, in press.

    Google Scholar 

  11. Langer, R., Rhine, W. D., Hsieh, D. S. T., Bawa, R. (1980) in: Controlled Release of Bioactive Material (Baker, R. W., ed.), pp. 83–98. Academic Press, New York.

    Google Scholar 

  12. Kozeny, J. (1927) Ber. Wien. Akad. 139A, 271.

    Google Scholar 

  13. Higuchi, T. (1963) J. Pharm. Sci. 50, 1145–1149.

    Google Scholar 

  14. Winsauer, W. O., Shearin Jr., H. M., Masson, P. H., Williams, M. (1952) Bull. Amer. Assoc. of Petrol. Geol. 36, 253–277.

    Google Scholar 

  15. Safford, R., Bassingthwaighte, B. (1977) Biophys. J. 20, 113–136.

    Google Scholar 

  16. Langer, R., Hsieh, D. S. T., Brown, L., Rhine, W. (1981) in: Better Therapy with Existing Drugs: New Uses and Delivery Systems, pp. 179–216, Biomedical Information Corp., New York.

    Google Scholar 

  17. Crank, J. (1975) Mathematics of Diffusion, Clarendon Press, Oxford.

    Google Scholar 

  18. Keller, K. H., Canales, E. R., Yum, S. I. (1971) J. Phys. Chem. 75, 379–387.

    Google Scholar 

  19. Paul, D. R., McSpadden, S. K. (1976) J. Memb. Sci. 1, 33–48.

    Google Scholar 

  20. Lee, P. I. (1980) J. Memb. Sci. 7, 255–275.

    Google Scholar 

  21. Rhine, W. D., Sukhatme, V., Hsieh, D. S. T., Langer, R. (1980) in: Controlled Release of Bioactive Materials (Baker, R. W., ed.), pp. 177–187, Academic Press, New York.

    Google Scholar 

  22. Hsieh, D. S. T., Rhine, W. D., Langer, R. (1983) J. Pharm. Sci. 72, 17–22.

    Google Scholar 

  23. Langer, R., Murray, J. (1983) Appl. Bioch. and Biotech. 8, 9–24.

    Google Scholar 

  24. Preis, I., Langer, R. (1979) J. Immunol. Methods 28, 193–197.

    Google Scholar 

  25. Langer, R., Fefferman, H., Gryska, P. V., Bergman, K. (1980) Can. J. Microbiol. 26, 274–278.

    Google Scholar 

  26. Silberstein, G. B., Daniel, C. W. (1982) Developmental Biol. 93, 272–278.

    Google Scholar 

  27. Brown, L., Wei, C., Langer, R. (1983) J. Pharm. Sci., in press.

  28. Miller, E. S., Peppos, N. A. and Winslow, D. N. (1983) J. Memb. Sci 14, 79–92.

    Google Scholar 

  29. Torchilin, V. P., Tischenko, E. G., Smirnov, V. N., Chazov, E. I. (1977) J. Biomed. Mater. Res. 11, 223–235.

    Google Scholar 

  30. Heller, J., Baker, R. W. (1980) in: Controlled Release of Bioactive Materials (Baker, R. W., ed.), pp. 1–18. Academic Press, New York.

    Google Scholar 

  31. Goosen, H. F. A., Leung, Y. F., O'Shea, G. M., Chou, S., Sun, A. (1983) Diabetes 32, 478–481.

    Google Scholar 

  32. Hsieh, D. S. T., Langer, R., Folkman, J. (1981) Proc. Natl. Acad. Sci. U.S.A., 78, 1863–1867.

    Google Scholar 

  33. Hsieh, D. S. T., Langer, R. (1983) in: Controlled Release of Bioactive Materials (T. J. Roseman and Z. Mansdorf, eds.) pp. 121–131, Marcel Dekker, NY.

    Google Scholar 

  34. Langer, R., Edelman, E., Hsieh, D. (1983) in: Biocompatible Polymers: Science and Technology (M. Szycher, ed.) pp. 585–596.

  35. Harris, R. W., Aulabaugh, A. E., Case, R. D., Dykes, M. K., Feld, W. A. (1976) in: Controlled Release Polymeric Formulation (Paul, D. R. and F. W Harris, eds.) Amer. Chem. Soc. Sym. Ser. Vol. 47, Washington, DC.

  36. Hopfenberg, H., Hsu, K. C. (1978) Polym. Eng. Sci. 18, 1186–1191.

    Google Scholar 

  37. Rosen, H. G., Chang, J., Wnek, G., Linhardt, R., Langer, R. (1983) Biomaterials 4, 131–133.

    Google Scholar 

  38. Zaffaroni, A. (1976) Chemtech 6, 756–761.

    Google Scholar 

Download references

Author information

Author notes

  1. Ronald A. Siegel

    Present address: School of Pharmacy, University of California at San Francisco, San Francisco, CA, 94143

Authors and Affiliations

  1. Whitaker College of Health Science, Technology, and Management, USA

    Ronald A. Siegel & Robert Langer

  2. Department of Electrical Engineering and Computer Science, USA

    Ronald A. Siegel

  3. Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA, 02139

    Robert Langer

  4. Department of Surgery, Children's Hospital Medical Center, Boston, MA, 02115

    Robert Langer

Authors
  1. Ronald A. Siegel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Langer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Siegel, R.A., Langer, R. Controlled Release of Polypeptides and Other Macromolecules. Pharm Res 1, 2–10 (1984). https://doi.org/10.1023/A:1016318423563

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016318423563

Keywords

Search

Navigation