Dissolution Rate Studies from a Stationary Disk/Rotating Fluid System

Abstract

The dissolution rates for hydrocortisone alcohol and acetate were determined using a stationary disk/ rotating fluid system. The hydrocortisone was compressed in a tablet die, and the die placed in a vessel above a rotating magnetic bar. Dissolution rates were evaluated in aqueous media under conditions involving the following independent variables: solubility (C _s), diffusion coefficient (D), viscosity (v), rotational speed (ω), and tablet radius (r). A design equation which relates dissolution rate (R) to these variables was formulated for the system R α C _s D ^2/3(v) ^−1/6(ω) ^1/2( r)^3/2 This design equation adequately represents the system, which is related to fluid mechanics and convective diffusion models. The fluid mechanics model assumes that the fluid ideally rotates as solid-body rotation and the momentum layer is initiated at the outside radius of the tablet die. The convective diffusion model is based on the formation of a diffusion layer at the outside radius of the dissolving surface and a predictable relationship between the momentum and the mass transport quantities of bulk viscosity and diffusion coefficient. This configuration, like the rotating disk in a stationary fluid, offers the attractive attribute of being useful to study drug release mechanisms for systems of pharmaceutical interest.