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Nasal Absorption of Leucine Enkephalin in Rats and the Effects of Aminopeptidase Inhibition, as Determined from the Percentage of the Dose Unabsorbed

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REFERENCES

  1. A. B. Shenvi. α-Aminoboronic acid derivatives: Effective inhibitors of aminopeptidases. Biochemistry 25:1286–1291 (1986).

    Google Scholar 

  2. M. A. Hussain, A. B. Shenvi, S. M. Rowe, and E. Shefter. The use of α-aminoboronic acid derivatives to stabilize peptide drugs during their intranasal absorption. Pharm. Res. 6:186–189 (1989).

    Google Scholar 

  3. M. A. Hussain, C. A. Koval, A. B. Shenvi, and B. J. Aungst. An aminoboronic acid derivative inhibits thymopentin metabolism by mucosal membrane aminopeptidases. Life Sci. 47:227–231 (1990).

    Google Scholar 

  4. B. J. Aungst, J. A. Blake, and M. A. Hussain. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and methods to increase absorption. J. Pharmacol. Exp. Ther. 259:139–145 (1991).

    Google Scholar 

  5. B. Matuszewska, G. G. Liversidge, F. Ryan, J. Dent, and P. L. Smith. In vitro study of intestinal absorption and metabolism of 8-L-arginine vasopressin and its analogues. Int. J. Pharm. 46:111–120 (1988).

    Google Scholar 

  6. M. D. Donovan, G. L. Flynn, and G. L. Amidon. Absorption of polyethylene glycols 600 through 2000: The molecular weight dependence of gastrointestinal and nasal absorption. Pharm. Res. 7:863–868 (1990).

    Google Scholar 

  7. A. Hussain, J. Faraj, Y. Aramaki, and J. E. Truelove. Hydrolysis of leucine enkephalin in the nasal cavity of the rat—a possible factor in the low bioavailability of nasally administered peptides. Biochem. Biophys. Res. Commun. 133:923–928 (1985).

    Google Scholar 

  8. J. A. Faraj, A. A. Hussain, Y. Aramaki, K. Iseki, M. Kagoshima, and L. W. Dittert. Mechanism of nasal absorption of drugs. III. Nasal absorption of leucine enkephalin. J. Pharm. Sci. 79:698–702 (1990).

    Google Scholar 

  9. V. H. L. Lee. Peptidase activities in absorptive mucosae. Biochem. Soc. Trans. 17:937–940 (1989).

    Google Scholar 

  10. M. A. Hussain, C. A. Koval, A. B. Shenvi, and B. J. Aungst. Recovery of rat nasal mucosa from the effects of aminopeptidase inhibitors. J. Pharm. Sci. 79:398–400 (1990).

    Google Scholar 

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Hussain, M.A., Aungst, B.J. Nasal Absorption of Leucine Enkephalin in Rats and the Effects of Aminopeptidase Inhibition, as Determined from the Percentage of the Dose Unabsorbed. Pharm Res 9, 1362–1364 (1992). https://doi.org/10.1023/A:1015882006897

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