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A prospective cohort study of cigarette smoking and pancreatic cancer in Japan

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Abstract

Objective: To examine the association of cigarette smoking with the risk of death from pancreatic cancer in a prospective cohort study. Methods: A total of 110,792 inhabitants, aged 40–79 years (46,465 men and 64,327 women), were enrolled from 1988 to 1990 and followed up for mortality to the end of 1997. At baseline a self-administered questionnaire was used to obtain information on cigarette smoking and other lifestyle factors. Results: During the follow-up period (mean ± SD: 8.1 ± 1.8 years), 225 deaths due to pancreatic cancer were identified. After adjustment for age, body mass index, history of diabetes mellitus, and gallbladder diseases, the relative risks (RRs) for current smokers were 1.6 (95% CI 0.95–2.6) in males, and 1.7 (95% CI: 0.84–3.3) in females. Men who smoked more than 40 cigarettes per day had a substantially higher risk of pancreatic cancer, with a RR of 3.3 (95% CI: 1.4–8.1). A significantly decreasing trend in risk with increasing years after smoking cessation was observed (trend p = 0.04) among male ex-smokers. The RRs were 0.85 (95% CI 0.36–2.0) and 0.85 (0.36–2.0) for those who had quit smoking for 10–19 and ≥20 years, respectively. Conclusions: Our cohort study confirmed that cigarette smoking was associated with an increased risk of death from pancreatic cancer.

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Authors and Affiliations

  1. Department of Public Health, Aichi Medical University School of Medicine, Aichi Prefecture, Japan

    Yingsong Lin & Shogo Kikuchi

  2. Department of Preventive Medicine/Biostatistics and Medical Decision making, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yingsong Lin & Yoshiyuki Ohno

  3. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-8550

    Akiko Tamakoshi

  4. Kyoto University Center for Student Health, Kyoto, Japan

    Takashi Kawamura

  5. Department of Epidemiology and Environmental Health, Juentendo University School of Medicine, Tokyo, Japan

    Yutaka Inaba & Michiko Kurosawa

  6. Department of Public Health, Akita University School of Medicine, Akita, Japan

    Yutaka Motohashi

Authors
  1. Yingsong Lin
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  2. Akiko Tamakoshi
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  3. Takashi Kawamura
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  4. Yutaka Inaba
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  5. Shogo Kikuchi
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  6. Yutaka Motohashi
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  7. Michiko Kurosawa
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  8. Yoshiyuki Ohno
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Lin, Y., Tamakoshi, A., Kawamura, T. et al. A prospective cohort study of cigarette smoking and pancreatic cancer in Japan. Cancer Causes Control 13, 249–254 (2002). https://doi.org/10.1023/A:1015052710213

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