Skip to main content

Advertisement

Log in

Synergistic Effect of Indomethacin and Bleomycin on Tumor Growth Produced by Activating Antitumor Immunity

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

REFERENCES

  1. H. Ohnishi, T. H. Lin, I. Nakajima, and T. M. Chu. Prostaglandin E2 from macrophages of murine splenocyte cultures inhibits the generation of lymphokine-activated killer cell activity. Tumour Biol. 12:99-110 (1991).

    Google Scholar 

  2. Y. Tanaka, T. Tanaka, and H. Ishitsuka. Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants. Cancer Res. 49:5935-5939 (1989).

    Google Scholar 

  3. T. Jimbo, T. Akimoto, and A. Tohgo. Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice. Cancer Immunol. Immunother. 40:10-16 (1995).

    Google Scholar 

  4. K. Nakata, S. Kashimoto, H. Yoshida, T. Oku, and S. Nakamura. Augmented antitumor effect of recombinant human interleukin-1 alpha by indomethacin. Cancer Res. 48:584-588 (1988).

    Google Scholar 

  5. K. Lundholm, J. Gelin, A. Hyltander, C. Leonnroth, R. Sandstreom, and G. Svaninger. Anti-inflammatory treatment may prolong survival in undernourished patients with metastatic solid tumors. Cancer Res. 54:5602-5606 (1994).

    Google Scholar 

  6. L. Yuan, M. Kobayashi, Y. Kuramitsu, Y. Li, K. Matsushita, and M. Hosokawa. Restoration of macrophage tumoricidal activity by bleomycin correlates with the decreased production of transforming growth factor beta in rats bearing KDH-8 hepatoma cells. Cancer Immunol. Immunother. 45:71-76 (1997).

    Google Scholar 

  7. S. Nonoyama and H. D. Ochs. Immune deficiency in SCID mice. Int. Rev. Immunol. 13:289-300 (1996).

    Google Scholar 

  8. S. Shimizu, Y. Nishikawa, K. Kuroda, S. Takagi, K. Kozaki, S. Hyuga, S. Saga, and M. Matsuyama. Involvement of transforming growth factor beta 1 in autocrine enhancement of gelatinase B secretion by murine metastatic colon carcinoma cells. Cancer Res. 56:3366-3370 (1996).

    Google Scholar 

  9. M. Tanaka, H. Miyazaki, Y. Takeda, and S. Takeo. Detection of serum cytokine levels in experimental cancer cachexia of colon 26 adenocarcinoma-bearing mice, Cancer Lett. 72:65-70 (1993).

    Google Scholar 

  10. M. Stoeck, S. Miescher, H. R. MacDonald, and V. Von-Fliedner. Transforming growth factors beta slow down cell-cycle progression in a murine interleukin-2 dependent T-cell line. J. Cell Physiol. 141:65-73 (1989).

    Google Scholar 

  11. M. Ogino, H. Hisatomi, and M. Hanazono. Effectiveness of indomethacin as an antitumor agent in colon 26-bearing conventional and nude mice, and telomerase activity in the tumors. Exp. Anim. 48:15-21 (1999).

    Google Scholar 

  12. P. I. Homem-de-Bittencourt-Junior, V. Pontieri, R. Curi, and O. V. Lopes. Effects of aspirin-like drugs on Walker 256 tumor growth and cachexia in rats. Braz. J. Med. Biol. Res. 22:1039-1042 (1989).

    Google Scholar 

  13. S. M. Mahony, S. A. Beck, and M. J. Tisdale. Comparison of weight loss induced by recombinant tumour necrosis factor with that produced by a cachexia-inducing tumour. Br. J. Cancer 57:385-389 (1988).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsushita, R., Hattori, K., Hayashi, K. et al. Synergistic Effect of Indomethacin and Bleomycin on Tumor Growth Produced by Activating Antitumor Immunity. Pharm Res 18, 243–245 (2001). https://doi.org/10.1023/A:1011048905732

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1011048905732

Navigation