Skip to main content
Log in

B-Lymphocytes in Autoimmune Thyroid Diseases (AITD)

  • Published:
Reviews in Endocrine and Metabolic Disorders Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Bagnasco M, Pesce G. Autoimmune thyroid disease: immunological model and clinical problem. Fundamental & Clinical Immunology 1996;4:7–27.

    Google Scholar 

  2. McLachlan SM, Pegg CAS, Atheron MC, Middleton SL, Dickinson A, Clark F, Proctor SJ, Proud G, Rees-Smith B. Subpopulations of thyroid autoantibody secreting lymphocytes in Graves' and Hashimoto's thyroid glands. Clin Exp Immunol 1986;65:319–328.

    Google Scholar 

  3. Canonica GW, Bagnasco M, Cosulich ME, Torre G, MacLachlan SM, Rees-Smith B. Why thyroid is the major site of thyroid autoantibody synthesis in autoimmune thyroid disease. Lancet 1983;21:1163.

    Google Scholar 

  4. Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 1994;15:788–830.

    Google Scholar 

  5. Totterman TH, Gordin A, Hayry P, Anderson LC, Makinen T. Accumulation of thyroid antigen-reactive T lymphocytes in the gland of patients with subacute thyroiditis. Clin Exp Immunol 1978;32:153–158.

    Google Scholar 

  6. Maanpaa J, Lautenschlager I, Nyberg M, Koskimies S, Kontiainen S. Thyroid-in®ltrating lymphocytes, thyroid function and HLA-DR in juvenile autoimmune thyroiditis. Acta Endocrinol 1989;121:573–577.

    Google Scholar 

  7. Paschke R, Vogg M, Swillens S, Usadel KH. Correlation of microsomal antibodies with the intensity of the intrathyroidal autoimmune process in Graves' disease. J Clin Endocrinol Metab 1993;21:939–943.

    Google Scholar 

  8. Katzin WE, Fishleder AJ, Tubbs R. Investigation of the clonality of lymphocytes in Hashimoto's thyroiditis using immunoglobulin and T cell receptor gene probes. Clin Immunol Immunopath 1989;51:264–271.

    Google Scholar 

  9. Weetman AP. Autoimmune thyroiditis: predisposition and pathogenesis. Clin Endocrinol 1992;36:307–323.

    Google Scholar 

  10. Grabar P. Hypothesis. Auto-antibodies and immunological theories: an analytical review. Clin Immunol Immunopathol 1975;4:453–466.

    Google Scholar 

  11. Bresler HS, Burek CL, Hoffman WH, Rose NR. Autoantigenic determinants on human thyroglobulin. II. Determinants recognized by autoantibodies from patients with chronic autoimmune thyroiditis compared to autoantibodies from healthy subjects. Clin Immunol Immunopathol 1990;54:76–78.

    Google Scholar 

  12. Grubeck-Loebenstein B, Buchan B, Chantry D, Kassal H, Londei M, Pirich K, Barrett K, Turner M, Waldhaus W, Feldmann M. Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1alpha and interleukin-6. Clin Exper Immunol 1989;77:324–330.

    Google Scholar 

  13. Zheng RQH, Abney E, Chu CQ, Field M, Grubeck-Loebenstein B, Maini RN, Feldmann M. Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods. Clin Exper Immunol 1991;83:314–319.

    Google Scholar 

  14. Roitt IM, Doniach D, Campbell RN, Hudson RV. Autoantibodies in Hashimoto's thyroiditis (lymphadenoid goitre). Lancet 1956;2:820–821.

    Google Scholar 

  15. Burek CL, Rose NR. Thyroglobulin antibodies. In: Autoantibodies. Peter JB, Shoenfeld Y, eds. New York Elsevier, 1996; 810–815.

    Google Scholar 

  16. McLachlan SM, Feldt-Rasmussen U, Young ET, Middleton SL, Blichert Toft M, Siersbaek-Nielsen K, Date J, Carr D, Clark F, Rees Smith B. IgG subclass distribution of thyroid autoantibodies: a `fingerprint' of an individual's response to thyroglobulin and thyroid microsomal antigen. Clin Endocrinol 1987;26:335–346.

    Google Scholar 

  17. Izumi M, Morita S, Yamashita Y, Hirayu H, Taura M, Sato K, Okamoto I, Nagataki S. Comparison of serum thyroglobulin of various diseases. Quebec City: Proc. 58th Meeting, Amer. Thyroid Assoc., 1982;22–25.

    Google Scholar 

  18. Sundick RS, Herdegen DM, Brown TR, Bagchi N. The incorporation of dietary iodine into thyroglobulin increases its immunogenicity. Endocrinology 1987;120:2078–2084.

    Google Scholar 

  19. Susuki S, Mitsunaga M, Miyoshi M, Kierakawa S, Nakagawa O, Miura H, Ofugi T. Cytophilic antithyroglobulin antibody in antibody dependent monocyte mediated cytotoxicity in Hashimoto's thyroiditis. J Clin Endocrinol Metab 1980;51:446–453.

    Google Scholar 

  20. Weetman AP, Black CM, Cohen SB, Tomlinson R, Banga JP, Reimer CP. Affinity purification of IgG subclasses and the distribution of thyroid auto-antibody reactivity in Hashimoto's thyroiditis. Scand J Immunol 1989;30:73–82.

    Google Scholar 

  21. Owen CA Jr. A review of autoimmunization in Hashimoto's thyroiditis. J Clin Endocrinol Metab 1958;18:1015–1023.

    Google Scholar 

  22. Volpé R. Immunology of human thyroid disease. In: Autoimmune diseases of the endocrine system. ed. Volpe R., Boca Raton: CRC Press, 1990;73–239.

    Google Scholar 

  23. Adler TR, Beall GN, Curd JG, Heiner DC, Shabharwal UK. Studies of complement activation and IgG subclass restriction of antithyroglobulin. Clin Exper Immunol 1984;56:383–389.

    Google Scholar 

  24. Nordyke RA, Gilbert FI, Miyamoto LA, Fleury KA. The superiority of anti-microsomal over anti-thyroglobulin antibodies for detecting Hashimoto's thyroiditis. Arch Int Med 1993;153:862–865.

    Google Scholar 

  25. Hawkins BR, Cheah PS, Dawkins RL, Whittingham S, Burger HG, Patel Y, Mackay IR, Welborn TA. Diagnostic significance of thyroid microsomal antibodies in a randomly selected population. Lancet 1980;2:1057–1059.

    Google Scholar 

  26. Aguayo J, Michaud P, litaka MM, DeGroot LJ, Row VV, Volpé R. Lack of effect of methimazole on thyrocyte cell-surface antigen expression. Autoimmunity 1989;2:133–143.

    Google Scholar 

  27. Chiovato L, Marcocci C, Mariotti S, Mori A, Pinchera A. L-thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibody in idiopathic myxedema and in hypothyroid but not euthyroid Hashimoto's thyroiditis. J Endocrinol Invest 1986;9:229–305.

    Google Scholar 

  28. Volpé R. Autoimmune thyroid disease. In: Autoimmunity and endocrine disease. Volpé R, ed., New York: Marcel Dekker, 1985;109–285.

    Google Scholar 

  29. Belyavin G, Trotter WR. Investigations of thyroid antigens reacting with Hashimoto's sera. Lancet 1959;1:648–652.

    Google Scholar 

  30. Rapoport B, McLachlan S. Thyroid peroxidase autoantibodies. In: Autoantibodies. Peter JB, Shoenfeld Y, eds. Elsevier, New York, 1996;816–821.

    Google Scholar 

  31. Czarnocka B, Ruf J, Ferrand M, Carayon P, Lissitzky S. Purification of the human thyroid peroxidase and identification as the microsomal antigen involved in autoimmune thyroid disease. FEBS Lett 1985;109:147–152.

    Google Scholar 

  32. Seto P, Hirayu H, Magnusson RP, Portman L, DeGroot LJ, Rapoport B. Isolation of a cDNA clone for the thyroid microsomal antigen. Homology with the gene for thyroid peroxidase. J Clin Invest 1987;80:1205–1208.

    Google Scholar 

  33. Libert F, Ruel J, Ludgate M, Swillens S, Alexander N, Vassart G, Dinsart C. Thyroperoxidase, an autoantigen with a mosaic structure made of nuclear and mitochondrial gene modules. EMBO J 1987;6:4193–4196.

    Google Scholar 

  34. Kohno Y, Yamaguchi F, Saito K, Niimi H, Nishikawa T, Hosoya T. Antithyroid peroxidase antibodies in sera from healthy subjects and from patients with chronic thyroiditis: differences in the ability to inhibit thyroid peroxidase activities. Clin Exper Immunol 1991;85:459–463.

    Google Scholar 

  35. Khoury EL, Bottazzo GF, Roitt I. The thyroid `microsomal' antibody revisited. Its paradoxical binding in vivo to the apical surface of the follicular epithelium. J Exper Med 1984;159:577–589.

    Google Scholar 

  36. Furmaniak J, Sanders J, Rees Smith B. Autoantigens in the autoimmune endocrinopathies. In: Autoimmune endocrinopathies, Contemporary Endocrinology Series. Volpé R, ed. Totowa, N.J. Humana Press, 1999;193–216.

    Google Scholar 

  37. Kohno Y, Naito N, Hiyama Y, Shimojo N, Suzuki N, Tarutani O, Nimi H, Nakajima H, Hosoya T. Thyroglobulin and thyroid peroxidase share common epitopes recognized by autoantibodies in patients with chronic autoimmune thyroiditis. J Clin Endocrinol Metab 1988;67:899–907.

    Google Scholar 

  38. McKenzie JW, Zakarija M. Antibodies in autoimmune thyroid disease. In: Werner's and Ingbar's The Thyroid, a fundamental and clinical text. seventh edition, Braverman LE, Utiger RD, ed. Philadelphia, Lippincott-Raven: 1996;416–432.

    Google Scholar 

  39. Bakke J, Werner SC. Etiology of toxic diffuse goiter. In: The Thyroid, a fundamental and clinical text. second edition, Werner SC, New York: Harper and Row, 1962;506–514.

    Google Scholar 

  40. Adams DD, Purves HD. Abnormal responses to the assay of thyrotrophin. Proc University Otago Med. School 1956;34:11–12.

    Google Scholar 

  41. McKenzie JM. Delayed thyroid response to serum from thyrotoxic patients. Endocrinology 1958;62:865–868.

    Google Scholar 

  42. McKenzie JM. Humoral factors in the pathogenesis of Graves' disease. Physiol Rev 1968;48:252–310.

    Google Scholar 

  43. Kriss JP, Pleshakov V, Chien JR. Isolation and identification of the long acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J Clin Endocrinol Metab 1964;24:1005–1028.

    Google Scholar 

  44. Volpé R. Thyrotropin receptor autoantibodies. In: Autoantibodies. Peter JB, Shoenfeld Y, ed. New York: Elsevier, 1996;822–829.

    Google Scholar 

  45. Manley SW, Bourke JR, Hawker RW. The thyrotrophin receptor in guinea pig thyroid homogenate: interaction with the long acting thyroid stimulator. J Endocrinol 1974;61:437–445.

    Google Scholar 

  46. Onaya T, Kotani M, Yamada T, Ochi Y. New in vitro tests to detect the thyroid stimulator in sera from hyperthyroid patients by measuring colloid droplet formation and cyclic AMP in human thyroid slices. J Clin Endocrinol Metab 1973;36:859–866.

    Google Scholar 

  47. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM. The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 1998;19:673–716.

    Google Scholar 

  48. Murakami M., Miashita K, Monden T, Yamada M, Iriuchijima T, Mori T. Evidence that a soluble form of TSH receptor is present in the peripheral blood of patients with Graves' disease. In: Eighty years of Hashimoto disease. Nagataki S, Mori T, Torizuka K, eds., Amsterdam: Elsevier, 1993;683–685.

    Google Scholar 

  49. Weetman AP. Thyroid associated ophthalmopathy and dermopathy. In: Autoimmune endocrinopathies, Contemporary Endocrinology Series. Volpé R, ed. Totowa, N.J.: Humana Press, 1999;245–270.

    Google Scholar 

  50. Raines KB, Baker JR, Lukes YG, Wartofsky L, Burman KD. Antithyrotrophin antibodies in the sera of Graves' disease patients. J Clin Endocrinol Metab 1985;61:217–222.

    Google Scholar 

  51. Paschke R, Teuber J, Schwedes U, Usadel KH. Is remission of Graves' disease regulated by anti-idiotypic antibodies? Acta Endocrinol 1987;115 (Suppl 281):99

    Google Scholar 

  52. Noh J, Hamada H, Saito H, Oyanagi H, Ishikawa N, Momotani N, Ito K, Mori H. Evidence against the importance in the disease process of antibodies to bovine thyroid stimulating hormone found in some patients with Graves' disease. J Clin Endocrinol Metab 1989;68:107–113.

    Google Scholar 

  53. Endo T, Kaneshige M, Nakazgo M, Kogai T, Saito T, Onaya T. Autoantibody against thyroid iodide transporter in the sera from patients with Hashimoto's thyroiditis possesses iodine transport inhibitory activity. Biochem Biophys Res Comm 1996;228:199–202.

    Google Scholar 

  54. Strakosch CR, Wenzel BE, Row VV, Volpé R. Immunology of autoimmune thyroid disease. N Engl J Med 1982;307: 1499–1507.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Volpe´, R. B-Lymphocytes in Autoimmune Thyroid Diseases (AITD). Rev Endocr Metab Disord 1, 79–86 (2000). https://doi.org/10.1023/A:1010068504848

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1010068504848

Navigation