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Influence of Granulocyte-Macrophage Colony Stimulating Factor on Pituitary-Adrenal Axis (PAA) in Rats In Vivo.

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Abstract

We have studied the in vivo influence of granulocyte-macrophage colony stimulating factor (GM-CSF) on blood plasma concentration of adrenocorticotropic hormone (ACTH) and corticosterone in Wistar rats. The administration of 10 µg/kg b.w. GM-CSF at 45 (P < 0.001), 90 (P < 0.01) and at 45 (P < 0.01), 90 (P < 0.001) and 180 min (P < 0.001) increased the secretion of ACTH and corticosterone, respectively. Prolonged administration of 10 µg/kg b.w. of GM-CSF increased the ACTH (P < 0.001) and corticosterone (P < 0.001) concentration in blood plasma. We have also found that chronic treatment with 10 µg/kg b.w. of GM-CSF increased the proliferative activity of corticotrophs (P < 0.05), but it did not significantly change the total cell proliferation in the anterior pituitary gland. Moreover, this cytokine increased cell proliferation of the adrenal cortex (P < 0.001). These experiments suggest that GM-CSF activates the pituitary-adrenal axis and support the hypothesis of bidirectional associations between the immune and neuroendocrine systems.

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Authors and Affiliations

  1. Department of Experimental Endocrinology, Medical University of Łódź, Sterlinga 3, 91-425, Łódź, Poland

    Krystyna Żylińska, Sławomir Mucha, Jan Komorowski, Hanna Pisarek & Henryk Stępień

  2. Department of Hematology, Medical University of Łódź, Pabianicka 62, 93-513, Łódź, Poland

    Anna Korycka & Tadeusz Robak

Authors
  1. Krystyna Żylińska
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  2. Sławomir Mucha
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  3. Jan Komorowski
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  7. Henryk Stępień
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Żylińska, K., Mucha, S., Komorowski, J. et al. Influence of Granulocyte-Macrophage Colony Stimulating Factor on Pituitary-Adrenal Axis (PAA) in Rats In Vivo.. Pituitary 2, 211–216 (1999). https://doi.org/10.1023/A:1009905427902

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