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TT Virus as a Human Pathogen: Significance and Problems

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Abstract

In 1997 TTV was detected using representational difference analysis (RDA) in serum of a patient with posttransfusion hepatitis unrelated to known hepatitis viruses. The genome of TTV is a circular single-stranded DNA molecule of 3852 nt with negative polarity. TTV possibly can be grouped either into the existing family Circoviridae or into a recently established virus family “Circinoviridae”. Analysis of the complete DNA nucleotide sequence of TTV identified three partially overlapping open reading frames (ORFs). Neither DNA nucleotide nor corresponding amino acid sequences of TTV do show significant homologies to known sequences. TTV DNA nucleotide sequences amplified by PCR from sera of different patients show considerable sequence variations. Although the natural route of transmission of TTV is still unknown, there is clear evidence for a transmission of TTV through blood and blood products. TTV DNA can be detected in the feces of infected individuals suggesting that it may be possible to attract TTV infection from environmental sources. Since the discovery of TTV, numerous studies have investigated the prevalence of TTV infections in different human population groups all over the world. All these studies are based on PCR detection systems, but the technical aspects of the PCR systems vary significantly between the different investigators. The results of the epidemiological studies do not show a clear picture. The discovery of TTV as a viral agent and particularly the identification of a high percentage of infected carriers in the healthy human population raises the following questions: Firstly, what is the origin and molecular relatedness of TT virus. Secondly, what is the significance of TTV as a human pathogen. And thirdly, what are the exact molecular mechanisms of viral replication. To answer these questions it will be necessary to determine the primary structure and the coding capacity of several TTV patient isolates.

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References

  1. Nishizawa T., Okamoto H., Konishi K., Yoshizawa H., Miyakawa Y., and Mayumi M., Biochem Biophys Res Commun 241, 92-97, 1997.

    Google Scholar 

  2. Okamoto H., Nishizawa T., Kato N., Ukita M., Ikeda H., Iizuka H., Miyakawa Y., and Mayumi M., Hepatol Res 10, 1-16, 1998.

    Google Scholar 

  3. Miyata H., Tsunoda H., Kazi A., Yamada A., Khan M.A., Murakami J., Kamahora T., Shiraki K., and Hino S., J Virol 73, 3582-3586, 1999.

    Google Scholar 

  4. Mushahwar I.K., Erker J.C., Muerhoff A.S., Leary T.P., Simons J.N., Birkenmeyer L.G., Chalmers M.L., Pilot-Matias T.J., and Dexai S.M., Proc Natl Acad Sci USA 96, 3177-3182, 1999.

    Google Scholar 

  5. Lukert P., de Boer G.F., Dale J.L., Keese P., McNulty M.S., Randles J.W., and Tischer I., in Murphy F.A., Fauquet C.M., Bishop D.H.L., Ghabrial S.A., Jarvis A.W., Martelli G.P., Mayo M.A., and Summers M.D. (eds). “Virus Taxonomy”. Sixth Report of the International Committee on Taxonomy of Viruses. Springer-Verlag, Vienna & New York, 166-168, 1995.

    Google Scholar 

  6. Claessens J.A., Schrier C.C., Mockett A.P., Jagt E.H., and Sondermeijer P.J., J Gen Virol 72, 2003-2006, 1991.

    Google Scholar 

  7. Bassami M.R., Berryman D., Wilcox G.E., and Raidal S.R., Virology 249, 453-459, 1998.

    Google Scholar 

  8. Meehan B.M., Creelan J.L., McNulty M.S., and Todd D., J Gen Virol 78, 221-227, 1997.

    Google Scholar 

  9. Niagro F.D., Forsthoefel A.N., Lawther R.P., Kamalanathan L., Ritchie B.W., Latimer K.S., and Lukert P.D., Arch Virol 143, 1723-1744, 1998.

    Google Scholar 

  10. Mankertz J., Buhk H.J., Blaess G., and Mankertz A., Virus Genes 16, 267-276, 1998.

    Google Scholar 

  11. Todd D., Creelan J.L., Meehan B.M., and McNulty M.S., Arch Virol 141, 1523-1534, 1996.

    Google Scholar 

  12. Phenix K.V., Meehan B.M., Todd D., and McNulty M.S., J Gen Virol 75, 905-909, 1994.

    Google Scholar 

  13. Todd D., Niagro F.D., Ritchie B.W., Curran W., Allan G.M., Lukert P.D., Latimer K.S., Steffens W.L., and McNulty M.S., Arch Virol 117, 129-135, 1991.

    Google Scholar 

  14. Takahashi K., Ohta Y., and Mishiro S., Hepatol Res 12, 111-120, 1998.

    Google Scholar 

  15. Biagini P., Gallian P., Attoui H., Cantaloube J.F., de Mícco P., and de L.X., J Gen Virol 80, 419-424, 1999.

    Google Scholar 

  16. Viazov S., Ross R.S., Niel C., de Oliveira J.M., Varenholz C., Da Villa G., and Roggendorf M., J Gen Virol 79, 3085-3089, 1998.

    Google Scholar 

  17. Tanaka Y., Mizokami M., Orito E., Ohno T., Nakano T., Kato T., Kato H., Mukaide M., Park Y.M., Kim B.S., and Ueda R., FEBS Lett 437, 201-206, 1998.

    Google Scholar 

  18. Sumazaki R., Yamada-Osaki M., Kajiwara Y., Shirahata A., and Matsui A., Lancet 352, 1308-1309, 1998.

    Google Scholar 

  19. Yamada-Osaki M., Sumazaki R., Noguchi E., Shibasaki M., and Matsui A., Lancet 352, 1309-1310, 1998.

    Google Scholar 

  20. Hirata D., Kaneko N., Iwamoto M., Yoshio T., Okazaki H., Mimori A., Masuyama J., and Minota S., Br J Rheumatol 37, 1361-1362, 1998.

    Google Scholar 

  21. Takahashi K., Hoshino H., Ohta Y., Yoshida N., and Mishiro S., Hepatol Res 12, 233-239, 1998.

    Google Scholar 

  22. Takayama S., Miura T., Matsuo S., Taki M., and Sugii S., Br J Haematol 104, 626-629, 1999.

    Google Scholar 

  23. Goto K., Sugiyama K., Terabe K., Mizutani F., and Wada Y., J Med Virol 57, 405-407, 1999.

    Google Scholar 

  24. Ikeda H., Takasu M., Inoue K., Okamoto H., Miyakawa Y., Mayumi M., Takayama S., Yamazaki S., Matsuo S., and Sugii S., J Hepatol 30, 205-212, 1999.

    Google Scholar 

  25. Oguchi T., Tanaka E., Orii K., Kobayashi M., Hora K., and Kiyosawa K., J Gastroenterol 34, 234-240, 1999.

    Google Scholar 

  26. Kanda Y., Tanaka Y., Kami M., Saito T., Asai T., Izutsu K., Yuji K., Ogawa S., Honda H., Mitani K., Chiba S., Yazaki Y., and Hirai H., Blood 93, 2485-2490, 1999.

    Google Scholar 

  27. Umemura T., Tanaka E., Ota M., Orii K., Yoshizawa H., Imai H., Sodeyama T., and Kiyosawa K., Hepatol Res 13, 212-220, 1999.

    Google Scholar 

  28. Fukuda Y., Nakano I., Katano Y., Kumada T., Hayashi K., Nakano S., and Hayakawa T., Infection 27, 125-127, 1999.

    Google Scholar 

  29. Tanaka H., Okamoto H., Luengrojanakul P., Chainuvati T., Tsuda F., Tanaka T., Miyakawa Y., and Mayumi M., J Med Virol 56, 234-238, 1998.

    Google Scholar 

  30. Poovorawan Y., Theamboonlers A., Jantaradsamee P., Kaew-in N., Hirsch P., and Tangkitvanich P., Infection 26, 355-358, 1998.

    Google Scholar 

  31. Tangkijvanich P., Hirsch P., Theamboonlers A., Nuchprayoon I., and Poovorawan Y., J Gastroenterol 34, 227-233, 1999.

    Google Scholar 

  32. Nakano T., Park Y.M., Mizokami M., Choi J.Y., Orito E., Ohno T., Kato T., Kondo Y., Tanaka Y., Kato H., and Kim B.S., J Hepatol 30, 389-393, 1999.

    Google Scholar 

  33. Prescott L.E. and Simmonds P., Lancet 339, 776-777, 1998.

    Google Scholar 

  34. Simmonds P., Davidson F., Lycett C., Prescott L.E., MacDonald D.M., Ellender J., Yap P.L., Ludlam C.A., Haydon G.H., Gillon J., and Jarvis L.M., Lancet 352, 191-195, 1998.

    Google Scholar 

  35. Naoumov N.V., Petrova E.P., Thomas M.G., and Williams R., Lancet 352, 195-197, 1998.

    Google Scholar 

  36. MacDonald D.M., Scott G.R., Clutterbuck D., and Simmonds P., J Infect Dis 179, 686-689, 1999.

    Google Scholar 

  37. Höhne M., Berg T., Müller A.R., and Schreier E., J Gen Virol 79, 2761-2764, 1998.

    Google Scholar 

  38. Viazov S., Ross R.S., Varenholz C., Lange R., Holtmann M., Niel C., and Roggendorf M., J Clin Virol 11, 183-187, 1998.

    Google Scholar 

  39. Schröter M., Feucht H., Zöllner B., Knödler B., Fischer L., and Laufs R., Hepatol Res 13, 205-211, 1999.

    Google Scholar 

  40. Gerolami V., Halfon P., Chambost H., Thuret I., and Halimi G., Lancet 352, 1309-1309, 1998.

    Google Scholar 

  41. Halfon P., Bourliere M., Feryn J.M., Khiri H., Chanas M., Salvadori J.M., and Ouzan D., J Hepatol 30, 552, 1999.

    Google Scholar 

  42. Prati D., Lin Y.H., De Mattei C., Liu J.K., Farma E., Ramaswamy L., Zanella A., Lee H., Rebulla P., Allain J.P., Sirchia G., and Chen B., Blood 93, 1502-1505, 1999.

    Google Scholar 

  43. Toniutto P., Fabris C., Falleti E., Lombardelli T., Gasparini V., Barillari G., Biffoni F., and Pirisi M., Blood 2426-2427, 1999.

  44. Charlton M., Adjei P., Poterucha J., Zein N., Moore B., Therneau T., Krom R., and Wiesner R., Hepatology 28, 839-842, 1998.

    Google Scholar 

  45. Desai S.M., Muerhoff A.S., Leary T.P., Erker J.C., Simons J.N., Chalmers M.L., Birkenmeyer L.G., Pilot-Matias T.J., and Mushahwar I.K., J Infect Dis 179, 1242-1244, 1999.

    Google Scholar 

  46. Niel C., de Oliveira J.M., Ross R.S., Gomes S.A., Roggendorf M., and Viazov S., J Med Virol 57, 259-263, 1999.

    Google Scholar 

  47. Tanaka Y., Mizokami M., Orito E., Nakano T., Kato T., Ding X., Ohno T., Ueda R., Sonoda S., Tajima K., Miura T., and Hayami M., J Med Virol 57, 264-268, 1999.

    Google Scholar 

  48. Davidson F., MacDonald D., Mokili J.L., Prescott L.E., Graham S., and Simmonds P., J Infect Dis 179, 1070-1076, 1999.

    Google Scholar 

  49. Takayama S., Yamazaki S., Matsuo S., and Sugii S., Biochem Biophys Res Commun 256, 208-211, 1999.

    Google Scholar 

  50. Simmonds P., Davidson F., and Jarvis L.M., Lancet 352, 1310-1311, 1999.

    Google Scholar 

  51. Tsuda F., Okamoto H., Ukita M., Tanaka T., Akahane Y., Konishi K., Yoshizawa H., Miyakawa Y., and Mayumi M., J Virol Methods 77, 199-206, 1999.

    Google Scholar 

  52. Okamoto H., Kato N., Iizuka H., Tsuda F., Miyakawa Y., and Mayumi M., J Med Virol 57, 252-258, 1999.

    Google Scholar 

  53. Okamura A., Yoshioka M., Kubota M., Kikuta H., Ishiko H., and Kobayashi K., J Med Virol 58, 174-177, 1999.

    Google Scholar 

  54. Fujiwara T., Iwata A., Iizuka H., Tanaka T., and Okamoto H., Lancet 352, 1310-1310, 1999.

    Google Scholar 

  55. Kobayashi M., Chayama K., Arase Y., Tsubota A., Suzuki Y., Koida I., Saitoh S., Murashima N., Ikeda K., Koike H., Hashimoto M., and Kumada H., J Gastroenterol Hepatol 14, 358-363, 1999.

    Google Scholar 

  56. Yokozaki S., Fukuda Y., Nakano I., Katano J., Okamuru M., and Naruse M., Blood 93, 3569-3570, 1999.

    Google Scholar 

  57. Okamoto H., Akahane Y., Ukita M., Fukuda M., Tsuda F., Miyakawa Y., and Mayumi M., J Med Virol 56, 128-132, 1998.

    Google Scholar 

  58. Cossart Y., Lancet 352, 164, 1998.

    Google Scholar 

  59. Imawari M., J Gastroenterol 34, 292-293, 1999.

    Google Scholar 

  60. Zuckerman A.J., Lancet 353, 932, 1999.

    Google Scholar 

  61. Erker J.C., Leary T.P., Desai S.M., Chalmers M.L., and Mushahwar I.K., J Gen Virol 80, 1743-1750, 1999.

    Google Scholar 

  62. Hijikata M., Takahashi K., and Mishiro S., Virology 260, 17-22, 1999.

    Google Scholar 

  63. Okamoto H., Nishizawa T., Ukita M., Takahashi M., Fukuda M., Iizuka H., Miyakawa Y., and Mayumi M., Virology 259, 437-448, 1999.

    Google Scholar 

  64. Okamoto H., Takahashi M., Nishizawa T., Ukita M., Fukuda M., Tsuda F., Miyakawa Y., and Mayumi M., Virology 259, 428-436, 1999.

    Google Scholar 

  65. Leary T.P., Erker J.C., Chalmers M.L., Desai S.M., and Mushahwar I.K., J Gen Virol 80, 2115-2120, 1999.

    Google Scholar 

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Authors and Affiliations

  1. Institut fu¨r Medizinische Virologie der Ruprecht-Karls-Universita¨t Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Federal Republic of, Germany J73@ix.urz.uni-heidelberg.de

    Joachim J. Bugert, Paul Schnitzler, Edda Tobiasch, Roland Kehm & Gholamreza Darai

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  1. Christoph Springfeld
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  2. Joachim J. Bugert
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Springfeld, C., Bugert, J.J., Schnitzler, P. et al. TT Virus as a Human Pathogen: Significance and Problems. Virus Genes 20, 35–45 (2000). https://doi.org/10.1023/A:1008156022845

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