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Characterization, expression analysis and chromosomal mapping of mouse Matrix Metalloproteinase-19 (MMP-19)

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Abstract

Using homology-based database screening, we have identified the mouse homologue for the recently described matrix metalloproteinase-19 (MMP-19). Sequencing of mouse MMP-19 resulted in a putative open reading frame (ORF) of 527 amino acids showing 84% identity to the human homologue. In mouse, MMP-19 appears to be most highly expressed in the liver; however, there is a detectable level of expression in all tissues analyzed. The major mouse MMP-19 transcript is almost twice as long as that of human. The COOH-terminal serine and threonine-rich domain is considerably longer in the mouse homologue. The mouse MMP-19 gene maps to very distal end of mouse chromosome 10.

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Authors and Affiliations

  1. The National Institute of Dental and Craniofacial Research, Bethesda, MD, USA

    John J. Caterina, Joanne Shi & Henning Birkedal-Hansen

  2. The National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    Christine A. Kozak

  3. Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL, USA

    Jeffrey A. Engler

Authors
  1. John J. Caterina
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  2. Joanne Shi
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  3. Christine A. Kozak
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  4. Jeffrey A. Engler
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  5. Henning Birkedal-Hansen
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Caterina, J.J., Shi, J., Kozak, C.A. et al. Characterization, expression analysis and chromosomal mapping of mouse Matrix Metalloproteinase-19 (MMP-19). Mol Biol Rep 27, 73–79 (2000). https://doi.org/10.1023/A:1007196529604

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  • DOI: https://doi.org/10.1023/A:1007196529604

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