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Chemical properties and cytotoxic activity of complexes of platinum(II) and palladium(II) containing dmso and various anions; synthesis and structural characterization of [Pt(dmso)2{O2(CO)2CCH2CH2CH2}]

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Abstract

Treatment of cis-[Pt(dmso)2Cl2] with 2 mol of KBr or KI leads to the formation of the analogous dibromide or diiodide complexes. Treatment of [M(dmso)2Cl2] [M = Pt (cis-) or Pd (trans-)] with AgNO3 (2 mol) in H2O followed by 1mol of potassium oxalate, maleate, cyclobutane dicarboxylate (CBDC), malonate or 2mol of potassium cyclohexane carboxylate or pivalate leads to the formation of the corresponding PtII and PdII carboxylate complexes. The single crystal X-ray structure determination of [Pt(dmso)2(CBDC)] has been discussed and compared with data on other related complexes. The in vitro cytotoxic activity of some of these complexes against eight tumour cell lines has been examined using the MTT-colorimetric assay.

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References

  1. T. A. K. Al-Allaf, L. J. Rashan, R. F. Khuzaie and W. F. Halaseh, Asian J. Chem., 8, 505 (1996); 9, 239 (1997).

    Google Scholar 

  2. B. Rosenberg, L. van Camp, J. E. Trosko and V. H. Mansour, Nature (London), 222, 38 (1969); B Rosenberg, Cancer Treat. Rep., 63, 1433 (1979).

    Google Scholar 

  3. K. R. Harrap, Cancer Treat. Rev., 12A, 21 (1985).

    Google Scholar 

  4. S. Winthrop, Eloxatine (Oxaplatin), 7th Int. Congress on Anti-Cancer Treat., 3–6 February 1997, Paris, France.

  5. L. R. Kelland, Crit. Rev. Oncol. Hematol., 15, 19 (1993); R. B. Weiss and M. C. Christian, Drugs, 46, 360 (1993); J. Reedijk, J. Chem. Soc., Chem. Commun., 801 (1996); B. Lippert, Gazz. Chim. Ital., 118, 153 (1988).

    Google Scholar 

  6. T. A. K. Al-Allaf, I. A. Mustafa and S. E. Al-Mukhatar, Transition Met. Chem., 18, 1 (1993).

    Google Scholar 

  7. T. A. K. Al-Allaf and L. J. Rashan, U.K. Pat Appl., GB 2 303 627A (26/02/1997).

  8. N. Farrell, D. M. Kiley, W. Schmidt and M. P. Hacker, Inorg. Chem., 29, 397 (1990).

    Google Scholar 

  9. T. A. K. Al-Allaf and L. J. Rashan, Research paper presented to 9th European Cancer Conference (ECCO 9), 14–18 September 1997, Hamburg, Germany; Eur. J. Cancer 33, 94 (1997).

    Google Scholar 

  10. I. M. Ismail and P. J. Sadler, J. Inorg. Biochem., 13, 205 (1980).

    Google Scholar 

  11. T. A. K. Al-Allaf, P. Castan, R. Turpin, S. Wimmer and B. Berrardinelle, Transition Met. Chem., 17, 579 (1992).

    Google Scholar 

  12. J. H. Price, A. N. Williamson, R. F. Schramm and B. B. Wayland, Inorg. Chem., 11, 1280 (1972).

    Google Scholar 

  13. T. A. K. Al-Allaf and L. J. Rashan, unpublished observations.

  14. H. Von Dreizler and G. Drendt, Z. Naturforsch., Teil A, 19, 512 (1964); K. K. Kannan and M. A. Viswamitra, Nature (London) 209, 1016 (1996).

    Google Scholar 

  15. M. J. Clear and J. D. Hoeschele, Bioinorg. Chem., 2, 187 (1973).

    Google Scholar 

  16. T. A. K. Al-Allaf, P. Castan, R. Turpin and S. Wimmer, C. R. Acad. Sci., 314, 1029 (1992).

    Google Scholar 

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Authors and Affiliations

  1. University of Mosul, Mosul, Iraq

    Talal A. K. Al-Allaf & Luay J. Rashan

  2. Anorganische Chemie II, Universität Ulm, D-89069, Ulm, Germany

    Adnan S. Abu-Surrah

  3. Institut für Anorganische Chemie der Universität Tübingen, Auf der Morgenstelle 18, D-72076, Tübingen, Germany

    Riad Fawzi & Manfred Steimann

Authors
  1. Talal A. K. Al-Allaf
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  2. Luay J. Rashan
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  3. Adnan S. Abu-Surrah
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  4. Riad Fawzi
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  5. Manfred Steimann
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Al-Allaf, T.A.K., Rashan, L.J., Abu-Surrah, A.S. et al. Chemical properties and cytotoxic activity of complexes of platinum(II) and palladium(II) containing dmso and various anions; synthesis and structural characterization of [Pt(dmso)2{O2(CO)2CCH2CH2CH2}]. Transition Metal Chemistry 23, 403–406 (1998). https://doi.org/10.1023/A:1006942125847

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  • DOI: https://doi.org/10.1023/A:1006942125847

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