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The proteasome-dependent proteolytic system

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Abstract

The 20S proteasome is an intriguingly large complex that acts as a proteolytic catalytic machine. Accumulating evidence indicates the existence of multiple factors capable of regulating the proteasome function. They are classified into two different categories, one type of regulator is PA700 or PA28 that is reversibly associated with the 20S proteasome to form enzymatically active proteasomes and the other type including a 300-kDa modulator and PI31 indirectly influences proteasome activity perhaps by promoting or suppressing the assembly of the 20S proteasome with PA700 or PA28. Thus, there have been documented two types of proteasomes composed of a core catalytic proteasome and a pair of symmetrically disposed PA700 or PA28 regulatory particle. Moreover, the recently-identified proteasome containing both PA28 and PA700 appears to play a significant role in the ATP-dependent proteolytic pathway in cells, as can the 26S proteasome which is known as a eukaryotic ATP-dependent protease.

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Authors and Affiliations

  1. The Tokyo Metropolitan Institute of Medical Science, and CREST, Japan Science and Technology Corporation (JST), 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8613, Japan

    Nobuyuki Tanahashi & Keiji Tanaka

  2. Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan

    Hiroyuki Kawahara

  3. Department of Biochemistry 2, The Jikei University School of Medicine, Minato-ku, Tokyo, 105-0003, Japan

    Yasuko Murakami

Authors
  1. Nobuyuki Tanahashi
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  2. Hiroyuki Kawahara
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  3. Yasuko Murakami
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  4. Keiji Tanaka
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Tanahashi, N., Kawahara, H., Murakami, Y. et al. The proteasome-dependent proteolytic system. Mol Biol Rep 26, 3–9 (1999). https://doi.org/10.1023/A:1006909522731

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