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10B quantitative determination in ppb range by particle tracks reading for boron neutron capture therapy

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Abstract

Quantitative determination of ppb-order 10B was carried out in a small number of cultured tumor cells by particle tracks by the 10B(n,α)7Li reactions using solid state nuclear track detector (SSNTD) for boron neutron capture therapy research. The detection limit of 10B concentration in tumor cells is less than 1·10-3 ppm under our experimental conditions which permits the quantitative determination of 10B in a small number of boronated tumor cells (105/ml = ca. 0.1 mg). Boron quantities in tumor cells determined were well compatible with the tumor cell killing effects of boron neutron capture therapy.

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Authors and Affiliations

  1. Radiation Oncology Research Laboratory, Graduate School of Medicine, Kyoto University, Kumatori, Osaka, Japan

    M. Takagaki, K. Ono, S-I. Masunaga & Y. Kinashi

  2. Department of Radiation Life Science, Research Reactor Institute, and Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kumatori, Osaka, Japan

    Y. Sakurai, T. Kobayashi, S-I. Miyatake & N. Hashimoto

Authors
  1. M. Takagaki
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  2. K. Ono
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  3. S-I. Masunaga
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  4. Y. Kinashi
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  5. Y. Sakurai
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  6. T. Kobayashi
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  7. S-I. Miyatake
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  8. N. Hashimoto
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Takagaki, M., Ono, K., Masunaga, SI. et al. 10B quantitative determination in ppb range by particle tracks reading for boron neutron capture therapy. Journal of Radioanalytical and Nuclear Chemistry 247, 389–392 (2001). https://doi.org/10.1023/A:1006726206689

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  • DOI: https://doi.org/10.1023/A:1006726206689

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