Abstract
Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness. Imaging characteristics were suggestive of a malignant neoplasm versus meningioma. The patient had a craniotomy for total excision of the lesion. Pathology showed a leiomyosarcoma. Metastatic work-up was negative. The patient refused radiation therapy, but is well without evidence of recurrence at 8 months follow-up.
The differential diagnosis for intracranial lesions in AIDS should be expanded to include leiomyosarcoma. Surgical resection of the lesion is recommended.
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References
Biggar RJ, Rabkin CS: The epidemiology of AIDS-related neoplasms. Hematol Oncol Clin North America 10: 997–1010, 1996
Chadwick EG, Conner EJ, Hanson ICG, Joshi VV, Abu-Farsakh H, Yogev R, McSherry G, McClain K, Murphy SB: Tumors of smooth-muscle origin in HIV-infected children. JAMA 263: 3182–3184, 1990
McClain KL, Leach CT, Jenson HB, Joshi VV, Pollack BH, Parmley RT, Dicarlo FJ, Chadwick EG, Murphy SB: Association of Epstein-Barr Virus with leiomyosarcomas in young people with AIDS. N Engl J Med 332: 12–18, 1995
McLoughlin LC, Nord KS, Joshi VV, DiCarlo J, Kane MJ: Disseminated leiomyosarcoma in a child with acquired immune deficiency syndrome. Cancer 67: 2718–2621, 1991
Mueller BU, Butler KM, Higham MC, Hussoon RN, Montrella KA, Pizzo PA, Feuerstein IM, Manjunath K: Smooth muscle tumors in children with human immunodeficiency virus infection. Pediatrics 90: 460–462, 1992
Ross JS, del Rosario A, Bui HX, Sonbati H, Solis O: Primary hepatic leiomyosarcoma in a child with the acquired immunodeficiency syndrome. Human Pathol 23: 69–72, 1992
Smith MB, Silverman JF, Raab SS, Towell BD, Geisinger KR: Fine-needle aspiration cytology of hepatic leiomyosarcoma. Diagn Cytopathol 11: 321–327, 1994
Zetler PJ, Filipenko JD, Bilbey JH, Schmidt N: Primary adrenal leiomyosarcoma in a man with acquired immunodeficiency syndrome (AIDS), Further evidence of an increase in smooth muscle tumors related to Epstein-Barr infection in AIDS. Arch Pathol Lab Med 119: 1164–1167, 1995
Paulus W, Slowik F, Jellinger K: Primary intracranial sarcomas: histopathological features of 19 cases. Histopathology 18: 395–402, 1991
Haykai HA, Wang A-M, Zamani A: Leiomyosarcoma metastatic to the brain: CT features and review. AJNR 8: 911–912, 1987
Prussia PR, Clarke HA, Mansoor G, Garriques S, Maheswaran B: Uterine leiomyosarcoma with intracerebral metastasis: a case report. J Nat Med Assoc 84: 368–370, 1992
Wronski M, de Palma P, Arbit E: Leiomyosarcoma of the uterus metastatic to brain: a case report and a review of the literature. Gynecol Oncol 54: 237–241, 1994
Anderson WR, Cameron JD, Tsai SH: Primary intracranial leiomyosarcoma. Case report with ultrastructural study. J Neurosurg 53: 401–405, 1980
Asai A, Yamada H, Murata S, Matsuno A, Tsutsumi K, Takemura T, Matsutani M, Takakura K: Primary leiomyosarcoma of the dura mater. Case report. J Neurosurg 68: 308–311, 1988
Buff BL, Schick RM, Norregaard T: Meningenal metastasis of leiomyosarcoma mimicking meningioma: CT and MR findings. J Comput Assist Tomogr 5: 166–167, 1991
De Vries J, Scheremet R, Altmannsberger M, Michilli R, Lindemann A, Hinkelbein W: Primary leiomyosarcoma of the spinal leptomeninges. J Neuro-Oncol 18: 25–31, 1994
Kidooka M, Okada T, Takayama S, Nakasu S, Handa J: Primary leiomyosarcoma of the spinal dura mater. Neuroradiology 33: 173–174, 1991
Louis DN, Richardson EP, Dickersin GR, Petrucci DA, Rosenberg AE, Ojemann RG: Primary intracranial leiomyosarcoma: Case report. J Neurosurg 71: 279–282, 1989
Skullerud K, Stenwig AE, Brandtzaeg P, Nesland JM, Kerty E, Langmoen I, Saeter G: Intracranial primary leiomyosarcoma arising in a teratoma of the pineal area. Clin Neuropathol 14: 245–248, 1995
Lee ES, Locker J, Nalesnik M, Reyes J, Jaffe R, Alashari M, Nour B, Tzakis A, Dickman PS: The association of Epstein-Barr Virus with smooth-muscle tumors occurring after organ transplantation. N Engl J Med 332: 19–25, 1995
Morgello S, Kotsianti A, Gumprecht JP, Moore F: Epstein-Barr virus-associated dural leiomyosarcoma in a man infected with human immmunodeficiency virus. J Neurosurg 86: 883–887, 1997
Eilber FR, Eckhardt J, Morton DL: Advances in the treatment of sarcomas of the extremity. Current status of limb salvage. Cancer 54: 2695–2701, 1984
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Litofsky, N.S., Pihan, G., Corvi, F. et al. Intracranial leiomyosarcoma: A neuro-oncological consequence of acquired immunodeficiency syndrome. J Neurooncol 40, 179–183 (1998). https://doi.org/10.1023/A:1006167629968
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DOI: https://doi.org/10.1023/A:1006167629968