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New cytotoxic drugs for intrathecal administration

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References

  1. McCully C, Balis F, Bacher J et al.: A Rhesus monkey model for continuous infusion of drugs into cerebrospinal fluid. Lab Anim Sci 40: 520–525, 1990

    Google Scholar 

  2. Blaney S, Balis F, Murphy R et al.: A phase I study of intrathecal mafosfamide in patients with refractory meningeal malignancies. Proc Am Soc Clin Oncol 11: 113, 1992

    Google Scholar 

  3. Bachur N, Collins J, Kelley J et al.: Diaziquone, 2,5-diaziridinyl-3,6-biscarboethoxyamino-1,4-benzoquinone, plasma, and cerebrospinal fluid kinetics. Clin Pharmacol Ther 31: 650–655, 1982

    Google Scholar 

  4. Curt G, Kelley J, Kufta C et al.: Phase II and pharmacokinetic study of aziridinylbenzoquinone [2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone, diaziquone, NSC 182986] in high-grade gliomas. Cancer Res 43: 6102–6105, 1983

    Google Scholar 

  5. Zimm S, Collins J, Curt G et al.: Cerebrospinal fluid pharmacokinetics of intraventricular and intravenous aziridinylbenzoquinone. Cancer Res 44: 1698–1701, 1984

    Google Scholar 

  6. Berg S, Balis F, Zimm S et al.: Phase I/II trial and pharmacokinetics of intrathecal diaziquone in refractory meningeal malignancies. J Clin Oncol 10: 143–148, 1992

    Google Scholar 

  7. Egorin M, Fox B, Spiegel J et al.: Cellular pharmacology in murine and human leukemic cell lines of diaziquone (NSC 182896). Cancer Res 45: 992–999, 1985

    Google Scholar 

  8. Beijnen J, Smith B, Keijer W et al.: High-performance liquid chromatographic analysis of the new antitumor drug DK&F 104864-A (NSC 609699) in plasma. J Pharm Biomed Anal 8: 789–794, 1990

    Google Scholar 

  9. Hertzberg R, Caranfa M, Holden K et al.: Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. J Med Chem 32: 715–717, 1989

    Google Scholar 

  10. Blaney S, Cole D, Balis F et al.: Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates. Cancer Res 53: 725–727, 1993

    Google Scholar 

  11. Blaney S, Cole D, Godwin D et al.: Intrathecal administration of topotecan in nonhuman primates. Cancer Chemother Pharmacol 36: 121–124, 1995

    Google Scholar 

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Authors and Affiliations

  1. Departments of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA

    Susan M. Blaney & David G. Poplack

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  1. Susan M. Blaney
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  2. David G. Poplack
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Blaney, S.M., Poplack, D.G. New cytotoxic drugs for intrathecal administration. J Neurooncol 38, 219–223 (1998). https://doi.org/10.1023/A:1005944622003

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