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Signal transduction pathways and their relevance in human astrocytomas

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Abstract

Aberrations in a number of signal transduction pathwayshave been identified as playing a key rolein the molecular pathogenesis of astrocytomas and theirprogression to high grade glioblastoma multiforme (GBM). GBMsare characterized by overexpression of the Platelet DerivedGrowth Factor Receptors (PDGFR) and their ligands (PDGF),as well as the Epidermal Growth Factor Receptor(EGF-R). These receptors activate the Ras pathway, akey cellular signal transduction pathway, culminating in theactivation of a wide range of Ras-dependent cellularevents. GBMs have also been found to eitheroverexpression or lose expression of various Protein KinaseC (PKC) isoforms. Major strides are being madein developing pharmacological agents which specifically inhibit thesegrowth factor receptors and intracellular signal transduction pathways.Elucidating the role of these pathways in GBMsis thus of major clinical importance, as thesenovel molecularly-targeted agents may prove of use inthe clinical management of GBMs in the future.

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  1. Division of Neurosurgery, The Toronto Hospital and University of Toronto, Toronto, Ontario, Canada

    Matthias M. Feldkamp

  2. Samuel-Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    Matthias M. Feldkamp, Nelson Lau & Abhijit Guha

  3. Division of Surgical Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada

    Abhijit Guha

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  3. Abhijit Guha
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Feldkamp, M.M., Lau, N. & Guha, A. Signal transduction pathways and their relevance in human astrocytomas. J Neurooncol 35, 223–248 (1997). https://doi.org/10.1023/A:1005800114912

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