Skip to main content
SpringerLink
Log in

Rapid Growth Mutants of Escherichia Coli

  • Published:
Acta Biotheoretica Aims and scope Submit manuscript

Abstract

If rapid growth (rap) mutants of Escherichia coli could be obtained, these might prove a valuable contribution to fields as diverse as growth rate control, biotechnology and the regulation of the bacterial cell cycle. To obtain rap mutants, a dnaQ mutator strain was grown for four and a half days continuously in batch culture. At the end of the selection period, there was no significant change in growth rate. This result means that selecting rap mutants may require an alternative strategy and a number of such alternatives are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  • Dykhuizen, D.E., and D.L. Hartl (1983). Selection in chemostats. Microbiological Reviews 47: 150–168.

    Google Scholar 

  • Jaffé, A., R. D'Ari, and V. Norris (1986). SOS-independent coupling between DNA replication and cell division in Escherichia coli. Journal of Bacteriology 165: 66–71.

    Google Scholar 

  • Jensen, P.R., O. Michelsen, and H.V. Westerhoff (1993). Control analysis of the dependence of Escherichia coli physiology on the H+ ATPase. Proc. Natl. Acad. Sci. USA 90: 8068–8072.

    Google Scholar 

  • Horiuchi, T., H. Maki, and M. Sekiguchi (1978). A new conditional lethal mutator (dnaQ49) in Escherichia coli K 12. Molecular and General Genetics 163: 277–283.

    Google Scholar 

  • Keener, J. and M. Nomura (1996). Regulation of ribosome synthesis. In: F.C. Neidhardt, eds., Escherichia coli and Salmonella, pp.1417–1431.

  • Koch, A.L. (1995). Bacterial Growth and Form. New York, Chapman and Hall.

    Google Scholar 

  • Norris, V. (1993). Sequestration of origins of chromosome replication in Escherichia coli by lipid compartments: the pocket hypothesis. Journal of Theoretical Biology 164: 239–244.

    Google Scholar 

  • Norris, V. and G.J. Hyland (1997). Do bacteria sing? Molecular Microbiology 24: 879–880.

    Google Scholar 

  • Woldringh, C.L., E. Mulder, P.G. Huls, and N. Vischer (1991). Toporegulation of bacterial division according to the nucleoid occlusion model. Research in Microbiology 142: 309–320

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Leicester, Medical Sciences Building, 110 Box 138, Leicester, LE1 9HN, UK

    James Canvin, Susan Grant, Primrose Freestone, Istvan Toth, Mirella Trinei & Kishor Modha

  2. Laboratoire Analyse et Modèles Stochastiques UPRESA 6085, Faculté des Sciences et Techniques, Université de Rouen, F76821, Mont Saint Aignan Cedex, France

    Dominique Cellier

  3. Institut Fédératif de Recherche 'Systèmes Intégrés', Faculté des Sciences et Techniques, Université de Rouen, F76821, Mont saint Aignan, France

    Vic Norris

Authors
  1. James Canvin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susan Grant
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Primrose Freestone
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Istvan Toth
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mirella Trinei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kishor Modha
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dominique Cellier
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Vic Norris
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Canvin, J., Grant, S., Freestone, P. et al. Rapid Growth Mutants of Escherichia Coli. Acta Biotheor 46, 161–166 (1998). https://doi.org/10.1023/A:1001186005373

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1001186005373

Keywords

Search

Navigation