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Structure of gangliosides from gonads of the starfish Evasterias retifera

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Abstract

Mono- and disialogangliosides were isolated from gonads of the starfish Evasterias retifera. Their structures were elucidated using chemical methods, GC-MS analysis, and enzymatic hydrolysis with neuraminidase. The monosialoganglioside has the structure 8-O-Me-Neu5Gc-α2→3-GalNAc-β1→3-Gal-β1→4-Glc-β1→1-Cer, while the disialoganglioside contains an additional Neu5Ac residue which glycosylates GalNAc in position 6. The lipid moieties of both gangliosides contain phytosphingosine (mainly C18:0) and two types of fatty acids, unsubstituted (mainly C16:0 and C18:0) and α-hydroxy acids (mainly α-hydroxy-C16:0).

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninskii prosp., 119991, Moscow, Russian Federation

    G. P. Smirnova

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  1. G. P. Smirnova
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Smirnova, G.P. Structure of gangliosides from gonads of the starfish Evasterias retifera . Russian Chemical Bulletin 52, 2270–2275 (2003). https://doi.org/10.1023/B:RUCB.0000011890.59554.d2

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