Skip to main content
Log in

Metal-Enhanced Fluorescence Solution-Based Sensing Platform

  • Published:
Journal of Fluorescence Aims and scope Submit manuscript

Abstract

In recent years our laboratories have reported the favorable effects for fluorophores placed in close proximity to surface immobilized silver nanostructures. These include; greater quantum yields, reduced lifetimes (increased photostability) and directional emission. However, while these findings are likely to find multifarious applications for surface assays based on enhanced fluorescence detection, a solution based enhanced sensing platform has yet to be realized. In this short, note, we show how SiO2-coated silver colloids, indeed provide for a solution based enhanced fluorescence sensing platform with a 3–5 fold enhancement typically observed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. J. R. Lakowicz (2001). Radiative decay engineering: Biophysical and biomedical applications. Appl. Biochem. 298,1-24.

    Google Scholar 

  2. C. D. Geddes and J. R. Lakowicz (2002). Metal-enhanced fluores-cence. J. Fluoresc. 12(2), 121-129.

    Google Scholar 

  3. J. R. Lakowicz, Y. Shen, S. D'Auria, J. Malicka, J. Fang, Z. Grcyzynski, and I. Gryczynski (2002). Radiative decay engineer-ing 2. Effects of silver island films on fluorescence intensity, lifetimes, and resonance energy transfer. Anal. Biochem. 301, 261-277.

    Google Scholar 

  4. C. D. Geddes, K. Aslan, I. Gryczynski, J. Malicka, and J. R. Lakowicz (2004). In C. D. Geddes and J. R. Lakowicz (Eds.), Noble Metal Nanostructure for Metal-Enhanced Fluorescence, Review Chapter for Annual Reviews in Fluorescence 2003, Kluwer Academic/Plenum Publishers, New York, pp. 365-401.

    Google Scholar 

  5. I. Gryczynski, J. Malicka, C. D. Geddes, and J. R. Lakowicz (2003). The CFS engineers the intrinsic radiative decay rate of low quantum yield fluorophores. J. Fluoresc. 12(1), 11-13.

    Google Scholar 

  6. C. D. Geddes, H. Cao, I. Gryczynski, Z. Gryczynski, J. Fang, and J. R. Lakowicz (2003). Metal-enhanced fluorescence due to silver colloids on a planar surface: Potential applications of Indocyanine green to in vivo imaging. J. Phys. Chem. A 107, 3443-3449.

    Google Scholar 

  7. A. Parfenov, I. Gryczynski, J. Malicka, C. D. Geddes, and J. R. Lakowicz (2003). Enhanced fluorescence from fluorophores on fractal silver surfaces. J. Phys. Chem. B 107(34), 8829-8833.

    Google Scholar 

  8. C. D. Geddes, A. Parfenov, D. Roll, I. Gryczynski, J. Malicka, and J. R. Lakowicz (2003). Silver fractal-like structures for metal-enhanced fluorescence: Enhanced fluorescence intensities and in-creased probe photostabilities. J. Fluoresc. 13(3), 267-276.

    Google Scholar 

  9. C. D. Geddes, H. Cao, and J. R. Lakowicz (2003). Enhanced pho-tostability of ICG in close proximity to Gold colloids. Spectrochem. Acta A 59(11), 2611-2617.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aslan, K., Lakowicz, J.R., Szmacinski, H. et al. Metal-Enhanced Fluorescence Solution-Based Sensing Platform. Journal of Fluorescence 14, 677–679 (2004). https://doi.org/10.1023/B:JOFL.0000047217.74943.5c

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:JOFL.0000047217.74943.5c

Navigation