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Molecular Pharmacology of High Voltage-Activated Calcium Channels

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Abstract

Voltage-gated calcium channels are key sources of calcium entry into the cytosol of many excitable tissues. A number of different types of calcium channels have been identified and shown to mediate specialized cellular functions. Because of their fundamental nature, they are important targets for therapeutic intervention in disorders such as hypertension, pain, stroke, and epilepsy. Calcium channel antagonists fall into one of the following three groups: small inorganic ions, large peptide blockers, and small organic molecules. Inorganic ions nonselectively inhibit calcium entry by physical pore occlusion and are of little therapeutic value. Calcium-channel-blocking peptides isolated from various predatory animals such as spiders and cone snails are often highly selective blockers of individual types of calcium channels, either by preventing calcium flux through the pore or by antagonizing channel activation. There are many structure-activity-relation classes of small organic molecules that interact with various sites on the calcium channel protein, with actions ranging from selective high affinity block to relatively nondiscriminatory action on multiple calcium channel isoforms. Detailed interactions with the calcium channel protein are well understood for the dihydropyridine and phenylalkylamine drug classes, whereas we are only beginning to understand the molecular actions of some of the more recently discovered calcium channel blockers. Here, we provide a comprehensive review of pharmacology of high voltage-activated calcium channels.

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References

  • Adams, M. E., Myers, R. A., Imperial, J. S., and Olivera, B. M., (1993). Biochemistry, 32, 12566–12570.

    PubMed  Google Scholar 

  • Akaike, N., Kostyuk, P. G., and Osipchuk, Y. V., (1989). J. Physiol. 412, 181–195.

    PubMed  Google Scholar 

  • Akaike, N., Lee, K. S., and Brown, A. M., (1978). J. Gen. Physiol. 71, 509–531.

    PubMed  Google Scholar 

  • Alps, B. J., (1992). Br. J. Clin. Pharmacol. 34, 199–206.

    PubMed  Google Scholar 

  • Arnoult, C., Villaz, M., and Florman, H. M., (1998). Mol. Pharmacol. 53, 1104–1111.

    PubMed  Google Scholar 

  • Avery, R. B., and Johnston, D., (1996). J. Neurosci. 16, 5567–5582.

    PubMed  Google Scholar 

  • Bangalore, R., Baindur, N., Rutledge, A., Triggle, D. J., and Kass, R. S., (1994). Mol. Pharmacol. 46, 660–666.

    PubMed  Google Scholar 

  • Bean, B. P., (1984). Proc. Natl. Acad. Sci. U.S.A. 81, 6388–6392.

    PubMed  Google Scholar 

  • Bean, B. P., (1985). J. Gen. Physiol. 86, 1–30.

    PubMed  Google Scholar 

  • Bean, B. P., (1989). Annu. Rev. Physiol. 51, 367–384.

    PubMed  Google Scholar 

  • Bech-Hansen, N. T., Naylor, M. J., Maybaum, T. A., Pearce, W. G., Koop, B., Fishman, G. A., Mets, M., Musarella, M. A., and Boycott, K. M., (1998). Nat. Genet. 19, 264–267.

    PubMed  Google Scholar 

  • Bechem, M., and Hoffmann, H., (1993). Pflugers Arch. 424, 343–353.

    PubMed  Google Scholar 

  • Becker, S., Prusak-Sochaczewski, E., Zamponi, G., Beck-Sickinger, A. G., Gordon, R. D., and French, R. J., (1992). Biochemistry, 31, 8229–8238.

    PubMed  Google Scholar 

  • Beedle, A. M., Hamid, J., and Zamponi, G. W., (2002). J. Membr. Biol. 187, 225–238.

    PubMed  Google Scholar 

  • Beedle, A. M., and Zamponi, G. W., (2000). Biophys. J. 79, 260–270.

    PubMed  Google Scholar 

  • Bernatchez, G., Sauve, R., and Parent, L., (2001). J. Membr. Biol. 184, 143–159.

    PubMed  Google Scholar 

  • Bezprozvanny, I., and Tsien, R. W., (1995). Mol. Pharmacol. 48, 540–549.

    PubMed  Google Scholar 

  • Biagi, B. A., and Enyeart, J. J., (1990). Am. J. Physiol. 259, C515–C520.

    PubMed  Google Scholar 

  • Birnbaumer, L., Campbell, K. P., Catterall, W. A., Harpold, M. M., Hofmann, F., Horne, W. A., Mori, Y., Schwartz, A., Snutch, T. P., Tanabe, T., and Tsien, R. W., (1994). Neuron, 13, 505–506.

    PubMed  Google Scholar 

  • Block, B. M., Stacey, W. C., and Jones, S. W., (1998). Biophys. J. 74, 2278–2284.

    PubMed  Google Scholar 

  • Bois, P., Romey, G., and Lazdunski, M., (1991). Pflugers Arch. 419, 651–656.

    PubMed  Google Scholar 

  • Boland, L. M., Morrill, J. A., and Bean, B. P., (1994). J. Neurosci. 14, 5011–5027.

    PubMed  Google Scholar 

  • Bourinet, E., Soong, T. W., Sutton, K., Slaymaker, S., Mathews, E., Monteil, A., Zamponi, G. W., Nargeot, J., and Snutch, T. P., (1999). Nat. Neurosci. 2, 407–415.

    PubMed  Google Scholar 

  • Bourinet, E., Stotz, S. C., Spaetgens, R. L., Dayanithi, G., Lemos, J., Nargeot, J., and Zamponi, G. W., (2001). Biophys. J. 81, 79–88.

    PubMed  Google Scholar 

  • Brauns, T., Cai, Z. W., Kimball, S. D., Kang, K. C., Haugland, R. P., Berger, W., Berjukov, S., Hering, S., Glossmann, H., and Striessnig, J., (1995). Biochemistry, 34, 3461–3469.

    PubMed  Google Scholar 

  • Busselberg, D., Evans, M. L., Rahmann, H., and Carpenter, D. O., (1991). J. Neurophysiol. 65, 786–795.

    PubMed  Google Scholar 

  • Busselberg, D., Michael, D., Evans, M. L., Carpenter, D. O., and Haas, H. L., (1992). Brain Res. 593, 77–81.

    PubMed  Google Scholar 

  • Busselberg, D., Platt, B., Michael, D., Carpenter, D. O., and Haas, H. L., (1994). J. Neurophysiol. 71, 1491–1497.

    PubMed  Google Scholar 

  • Byerly, L., Chase, P. B., and Stimers, J. R., (1985). J. Gen. Physiol. 85, 491–518.

    PubMed  Google Scholar 

  • Cai, D., Mulle, J. G., and Yue, D. T., (1997). Mol. Pharmacol. 51, 872–881.

    PubMed  Google Scholar 

  • Castellano, A., Wei, X., Birnbaumer, L., and Perez-Reyes, E., (1993a). J. Biol. Chem. 268, 12359–12366.

    PubMed  Google Scholar 

  • Castellano, A., Wei, X., Birnbaumer, L., and Perez-Reyes, E., (1993b). J. Biol. Chem. 268, 3450–3455.

    PubMed  Google Scholar 

  • Catterall, W. A., (2000). Annu. Rev. Cell Dev. Biol. 16, 521–555.

    PubMed  Google Scholar 

  • Chouabe, C., Drici, M. D., Romey, G., and Barhanin, J., (2000). Therapie, 55, 195–202.

    PubMed  Google Scholar 

  • Chu, P. J., Robertson, H. M., and Best, P. M., (2001). Gene 280, 37–48.

  • Chuang, R. S., Jaffe, H., Cribbs, L., Perez-Reyes, E., and Swartz, K. J., (1998). Nat. Neurosci. 1, 668–674.

    PubMed  Google Scholar 

  • Cloues, R. K., Cibulsky, S. M., and Sather, W. A., (2000). J. Gen. Physiol. 116, 569–586.

    PubMed  Google Scholar 

  • Cox, B., (2000). Curr. Rev. Pain, 4, 488–498.

    PubMed  Google Scholar 

  • Cribbs, L. L., Gomora, J. C., Daud, A. N., Lee, J. H., and Perez-Reyes, E., (2000). FEBS Lett. 466, 54–58.

    PubMed  Google Scholar 

  • Cribbs, L. L., Lee, J. H., Yang, J., Satin, J., Zhang, Y., Daud, A., Barclay, J., Williamson, M. P., Fox, M., Rees, M., and Perez-Reyes, E., (1998). Circ. Res. 83, 103–109.

    PubMed  Google Scholar 

  • Diochot, S., Richard, S., Baldy-Moulinier, M., Nargeot, J., and Valmier, J., (1995). Pflugers Arch. 431, 10–19.

    PubMed  Google Scholar 

  • Dolmetsch, R. E., Pajvani, U., Fife, K., Spotts, J. M., and Greenberg, M. E., (2001). Science, 294, 333–339.

    PubMed  Google Scholar 

  • Döring, F., Degtiar, V. E., Grabner, M., Striessnig, J., Hering, S., and Glossman, H., (1996). J. Biol. Chem. 271, 11745–11749.

    PubMed  Google Scholar 

  • Droogmans, G., and Callewaert, G., (1986). Pflugers Arch. 406, 259–265.

    PubMed  Google Scholar 

  • Dubel, S. J., Starr, T. V., Hell, J., Ahlijanian, M. K., Enyeart, J. J., Catterall, W. A., and Snutch, T. P., (1992). Proc. Natl. Acad. Sci. U.S.A. 89, 5058–5062.

    PubMed  Google Scholar 

  • Dunlap, K., Luebke, J. I., and Turner, T. J., (1995). Trends Neurosci. 18, 89–98.

    PubMed  Google Scholar 

  • Dzhura, I. O., Naidenov, V. G., Lyubanova, O. P., Kostyuk, P. G., and Shuba, Y. M., (1996). Neuroscience, 70, 729–738.

    PubMed  Google Scholar 

  • Eller, P., Berjukov, S., Wanner, S., Huber, I., Hering, S., Knaus, H. G., Toth, G., Kimball, S. D., and Striessnig, J., (2000). Br. J. Pharmacol. 130, 669–677.

    PubMed  Google Scholar 

  • Ellinor, P. T., Zhang, J. F., Horne, W. A., and Tsien, R. W., (1994). Nature, 372, 272–275.

    PubMed  Google Scholar 

  • Ellis, S. B., Williams, M. E., Ways, N. R., Brenner, R., Sharp, A. H., Leung, A. T., Campbell, K. P., McKenna, E., Koch, W. J., Hui, A., Schwartz, A., and Harpold, M. M., (1988). Science, 241, 1661–1664.

    PubMed  Google Scholar 

  • Enyeart, J. J., Biagi, B. A., Day, R. N., Sheu, S. S., and Maurer, R. A., (1990). J. Biol. Chem. 265, 16373–16379.

    PubMed  Google Scholar 

  • Enyeart, J. J., Biagi, B. A., and Mlinar, B., (1992). Mol. Pharmacol. 42, 364–372.

    PubMed  Google Scholar 

  • Ertel, E. A., Campbell, K. P., Harpold, M. M., Hofmann, F., Mori, Y., Perez-Reyes, E., Schwartz, A., Snutch, T. P., Tanabe, T., Birnbaumer, L., Tsien, R. W., and Catterall, W. A., (2000). Neuron, 25, 533–535.

    PubMed  Google Scholar 

  • Ertel, S. I., and Ertel, E. A., (1997). Trends Pharmacol. Sci. 18, 37–42.

    PubMed  Google Scholar 

  • Felix, R., (1999). Receptors Channels, 6, 351–362.

    PubMed  Google Scholar 

  • Feng, Z. P., Doering, C. J., Winkfein, R. J., Beedle, A. M., Spafford, J. D., and Zamponi, G. W., (2003). Determinants of inhibition of transiently expressed calcium channels by ω-conotoxin GVIA and MVIIA., J. Biol. Chem. 278, 20171–20178.

    PubMed  Google Scholar 

  • Feng, Z. P., Hamid, J., Doering, C., Bosey, G. M., Snutch, T. P., and Zamponi, G. W., (2001). J. Biol. Chem. 276, 15728–15735.

    PubMed  Google Scholar 

  • Field, M. J., Hughes, J., and Singh, L., (2000). Br. J. Pharmacol. 131, 282–286.

    PubMed  Google Scholar 

  • Fletcher, C. F., Lutz, C. M., O'Sullivan, T. N., Shaughnessy, J. D., Jr., Hawkes, R., Frankel, W. N., Copeland, N. G., and Jenkins, N. A.,(1996). Cell, 87, 607–617.

    PubMed  Google Scholar 

  • Fox, A. P., Nowycky, M. C., and Tsien, R. W., (1987). J. Physiol. 394, 149–172.

    PubMed  Google Scholar 

  • Fox, J. A., (1995). Pflugers Arch. 429, 873–875.

    PubMed  Google Scholar 

  • French, R. J., Prusak-Sochaczewski, E., Zamponi, G. W., Becker, S., Kularatna, A. S., and Horn, R., (1996). Neuron, 16, 407–413.

    PubMed  Google Scholar 

  • Fujita, Y., Mynlieff, M., Dirksen, R. T., Kim, M. S., Niidome, T., Nakai, J., Friedrich, T., Iwabe, N., Miyata, T., Furuichi, T., Furutama, D., Mikoshiba, K., Mori, Y., and Beam, K. G., (1993). Neuron, 10, 585–598.

    PubMed  Google Scholar 

  • Galizzi, J. P., Fosset, M., Romey, G., Laduron, P., and Lazdunski, M., (1986). Proc. Natl. Acad. Sci. U.S.A. 83, 7513–7517.

    PubMed  Google Scholar 

  • Garcia, M. L., King, V. F., Shevell, J. L., Slaughter, R. S., Suarez-Kurtz, G., Winquist, R. J., and Kaczorowski, G. J., (1990). J. Biol. Chem. 265, 3763–3771.

    PubMed  Google Scholar 

  • Gee, N. S., Brown, J. P., Dissanayake, V. U., Offord, J., Thurlow, R., and Woodruff, G. N., (1996). J. Biol. Chem. 271, 5768–5776.

    PubMed  Google Scholar 

  • Gilquin, B., Lecoq, A., Desne, F., Guenneugues, M., Zinn-Justin, S., and Menez, A., (1999). Proteins, 34, 520–532.

    PubMed  Google Scholar 

  • Glossmann, H., and Striessnig, J., (1990). Rev. Physiol. Biochem. Pharmacol. 114, 1–105.

    PubMed  Google Scholar 

  • Gomora, J. C., Enyeart, J. A., and Enyeart, J. J., (1999). Mol. Pharmacol. 56, 1192–1197.

    PubMed  Google Scholar 

  • Gould, R. J., Murphy, K. M., Reynolds, I. J., and Snyder, S. H., (1983). Proc. Natl. Acad. Sci. U.S.A. 80, 5122–5125.

    PubMed  Google Scholar 

  • Grabner, M., Wang, Z., Hering, S., Striessnig, J., and Glossmann, H., (1996). Neuron, 16, 207–218.

    PubMed  Google Scholar 

  • Grantham, C. J., Bowman, D., Bath, C. P., Bell, D. C., and Bleakman, D., (1994a). Neuropharmacology, 33, 255–258.

    PubMed  Google Scholar 

  • Grantham, C. J., Main, M. J., and Cannell, M. B., (1994b). Br. J. Pharmacol. 111, 483–488.

    PubMed  Google Scholar 

  • Gubin, J., de Vogelaer, H., Inion, H., Houben, C., Lucchetti, J., Mahaux, J., Rosseels, G., Peiren, M., Clinet, M., Polster, P., and Chatelain, P., (1993). J. Med. Chem. 36, 1425–1433.

    PubMed  Google Scholar 

  • Hagiwara, S., and Byerly, L., (1981). Annu. Rev. Neurosci. 4, 69–125.

    PubMed  Google Scholar 

  • Hagiwara, S., and Takahashi, K., (1967). J. Gen. Physiol. 50, 583–601.

    PubMed  Google Scholar 

  • Handrock, R., Rao-Schymanski, R., Klugbauer, N., Hofmann, F., and Herzig, S., (1999). J. Physiol. 521, (Pt. 1), 31–42.

    PubMed  Google Scholar 

  • Hanson, J. E., and Smith, Y., (2002). J. Comp. Neurol. 442, 89–98.

    PubMed  Google Scholar 

  • Heading, C., (1999). Curr. Opin. CPNS Invest Drugs, 1, 153–166.

    Google Scholar 

  • Hell, J. W., Westenbroek, R. E., Warner, C., Ahlijanian, M. K., Prystay, W., Gilbert, M. M., Snutch, T. P., and Catterall, W. A., (1993). J.CellBiol. 123, 949–962.

    Google Scholar 

  • Hering, S., Aczel, S., Grabner, M., Döring, F., Berjukow, S., Mitterdorfer, J., Sinnegger, M. J., Striessnig, J., Degtiar, V. E., Wang, Z., and Glossmann, H., (1996). J. Biol. Chem. 271, 24471–24475.

    PubMed  Google Scholar 

  • Hering, S., Aczel, S., Kraus, R. L., Berjukow, S., Striessnig, J., and Timin, E. N., (1997). Proc. Natl. Acad. Sci. U.S.A. 94, 13323–13328.

    PubMed  Google Scholar 

  • Hering, S., Bolton, T. B., Beech, D. J., and Lim, S. P., (1989). Circ. Res. 64, 928–936.

    PubMed  Google Scholar 

  • Hering, S., Savchenko, A., Strubing, C., Lakitsch, M., and Striessnig, J., (1993). Mol. Pharmacol. 43, 820–826.

    PubMed  Google Scholar 

  • Hess, P., (1990). Annu. Rev. Neurosci. 13, 337–356.

    PubMed  Google Scholar 

  • Hille, B., (1992). Ionic Channels of Excitable Membranes: Calcium Channels, Sinauer Associates Inc., Massachusetts, pp. 83–114.

    Google Scholar 

  • Hillyard, D. R., Monje, V. D., Mintz, I. M., Bean, B. P., Nadasdi, L., Ramachandran, J., Miljanich, G., Azimi-Zoonooz, A., McIntosh, J. M., Cruz, L. J., Imperial, J. S., and Olivera, B. M., (1992). Neuron, 9, 69–77.

    PubMed  Google Scholar 

  • Hockerman, G. H., Johnson, B. D., Scheuer, T., and Catterall, W. A., (1995). J. Biol. Chem. 270, 22119–22122.

    PubMed  Google Scholar 

  • Hu, L. Y., Ryder, T. R., Rafferty, M. F., Feng, M. R., Lotarski, S. M., Rock, D. M., Sinz, M., Stoehr, S. J., Taylor, C. P., Weber, M. L., Bowersox, S. S., Miljanich, G. P., Millerman, E., Wang, Y. X., and Szoke, B. G., (1999). J. Med. Chem. 42, 4239–4249.

    PubMed  Google Scholar 

  • Huber, I., Wappl, E., Herzog, A., Mitterdorfer, J., Glossmann, H., Langer, T., and Striessnig, J., (2000). Biochem. J. 347, (Pt. 3), 829–836.

    PubMed  Google Scholar 

  • Ito, H., Klugbauer, N., and Hofmann, F., (1997). Mol. Pharmacol. 52, 735–740.

    PubMed  Google Scholar 

  • Kaczorowski, G. J., Slaughter, R. S., and Garcia, M. L., (1994). In Ion Channels in the Cardiovascular System: Function and Dysfunction: Strategies to Discover Novel Ion Channel Modulators (Spooner, P., ed.), pp. 463–487.

  • Kass, R. S., Arena, J. P., and Chin, S., (1991). J. Gen. Physiol. 98, 63–75.

    PubMed  Google Scholar 

  • Kenny, B. A., Fraser, S., and Spedding, M., (1993). Br. J. Pharmacol. 108, 93–99.

    PubMed  Google Scholar 

  • Kim, C., Jun, K., Lee, T., Kim, S. S., McEnery, M. W., Chin, H., Kim, H. L., Park, J. M., Kim, D. K., Jung, S. J., Kim, J., and Shin, H. S., (2001a). Mol. Cell Neurosci. 18, 235–245.

    PubMed  Google Scholar 

  • Kim, D., Song, I., Keum, S., Lee, T., Jeong, M. J., Kim, S. S., McEnery, M. W., and Shin, H. S., (2001b). Neuron, 31, 35–45.

    PubMed  Google Scholar 

  • Kim, H. L., Kim, H., Lee, P., King, R. G., and Chin, H., (1992). Proc. Natl. Acad. Sci. U.S.A. 89, 3251–3255.

    PubMed  Google Scholar 

  • King, V. F., Garcia, M. L., Himmel, D., Reuben, J. P., Lam, Y. K., Pan, J. X., Han, G. Q., and Kaczorowski, G. J., (1988). J. Biol. Chem. 263, 2238–2244.

    PubMed  Google Scholar 

  • King, V. F., Garcia, M. L., Shevell, J. L., Slaughter, R. S., and Kaczorowski, G. J., (1989). J. Biol. Chem. 264, 5633–5641.

    PubMed  Google Scholar 

  • Klugbauer, N., Lacinova, L., Marais, E., Hobom, M., and Hofmann, F., (1999). J. Neurosci. 19, 684–691.

    PubMed  Google Scholar 

  • Koschak, A., Reimer, D., Huber, I., Grabner, M., Glossmann, H., Engel, J., and Striessnig, J., (2001). J. Biol. Chem. 276, 22100–22106.

    PubMed  Google Scholar 

  • Kostyuk, P. G., Krishtal, O. A., and Shakhovalov, Y. A., (1977). J. Physiol. 270, 545–568.

    PubMed  Google Scholar 

  • Kraus, R., Reichl, B., Kimball, S. D., Grabner, M., Murphy, B. J., Catterall, W. A., and Striessnig, J., (1996). J. Biol. Chem. 271, 20113–20118.

    PubMed  Google Scholar 

  • Kraus, R. L., Hering, S., Grabner, M., Ostler, D., and Striessnig, J., (1998). J. Biol. Chem. 273, 27205–27212.

    PubMed  Google Scholar 

  • Kraus, R. L., Sinnegger, M. J., Koschak, A., Glossmann, H., Stenirri, S., Carrera, P., and Striessnig, J., (2000). J. Biol. Chem. 275, 9239–9243.

    PubMed  Google Scholar 

  • Kulak, J. M., Nguyen, T. A., Olivera, B. M., and McIntosh, J. M., (1997). J. Neurosci. 17, 5263–5270.

    PubMed  Google Scholar 

  • Kumar, P. P., Stotz, S. C., Paramashivappa, R., Beedle, A. M., Zamponi, G. W., and Rao, A. S., (2002). Mol. Pharmacol. 61, 649–658.

    PubMed  Google Scholar 

  • Kurokawa, J., Adachi-Akahane, S., and Nagao, T., (1997). Mol. Pharmacol. 51, 262–268.

    PubMed  Google Scholar 

  • Kwan, C. Y., and Wang, Z. L., (1993). Eur. J. Pharmacol. 238, 431–434.

    PubMed  Google Scholar 

  • Kwan, Y. W., Bangalore, R., Lakitsh, M., Glossmann, H., and Kass, R. S., (1995). J. Mol. Cell Cardiol. 27, 253–262.

    PubMed  Google Scholar 

  • Lacerda, A. E., Kim, H. S., Ruth, P., Perez-Reyes, E., Flockerzi, V., Hofmann, F., Birnbaumer, L., and Brown, A. M., (1991). Nature, 352, 527–530.

    PubMed  Google Scholar 

  • Lacinova, L., Klugbauer, N., and Hofmann, F., (2000a). Gen. Physiol. Biophys. 19, 121–136.

    PubMed  Google Scholar 

  • Lacinova, L., Klugbauer, N., and Hofmann, F., (2000b). Pflugers Arch. 440, 50–60.

    PubMed  Google Scholar 

  • Lampe, R. A., Defeo, P. A., Davison, M. D., Young, J., Herman, J. L., Spreen, R. C., Horn, M. B., Mangano, T. J., and Keith, R. A., (1993). Mol. Pharmacol. 44, 451–460.

    PubMed  Google Scholar 

  • Lansman, J. B., (1990). J. Gen. Physiol. 95, 679–696.

    PubMed  Google Scholar 

  • Lansman, J. B., Hess, P., and Tsien, R. W., (1986). J. Gen. Physiol. 88, 321–347.

    PubMed  Google Scholar 

  • Lee, J. H., Gomora, J. C., Cribbs, L. L., and Perez-Reyes, E., (1999). Biophys. J. 77, 3034–3042.

    PubMed  Google Scholar 

  • Lee, K. S., and Tsien, R. W., (1983). Nature, 302, 790–794.

    PubMed  Google Scholar 

  • Lewis, R. J., Nielsen, K. J., Craik, D. J., Loughnan, M. L., Adams, D. A., Sharpe, I. A., Luchian, T., Adams, D. J., Bond, T., Thomas, L., Jones, A., Matheson, J. L., Drinkwater, R., Andrews, P. R., and Alewood, P. F., (2000). J. Biol. Chem. 275, 35335–35344.

    PubMed  Google Scholar 

  • Li-Smerin, Y., and Swartz, K. J., (1998). Proc. Natl. Acad. Sci. U.S.A, 95, 8585–8589.

    PubMed  Google Scholar 

  • Li-Smerin, Y., and Swartz, K. J., (2001). J. Gen. Physiol. 117, 205–218.

    PubMed  Google Scholar 

  • Martin, D. J., McClelland, D., Herd, M. B., Sutton, K. G., Hall, M. D., Lee, K., Pinnock, R. D., and Scott, R. H., (2002). Neuropharmacology, 42, 353–366.

    PubMed  Google Scholar 

  • Matsuda, Y., Saegusa, H., Zong, S., Noda, T., and Tanabe, T., (2001). Biochem. Biophys. Res. Commun. 289, 791–795.

    PubMed  Google Scholar 

  • McClelland, D., Herd, M. B., Martin, B. L., Sutton, K., Lee, K., and Scott, R. H., (2000). J. Physiol. 528P:C53.

    Google Scholar 

  • McCleskey, E. W., (1994). Curr. Opin. Neurobiol. 4, 304–312.

    PubMed  Google Scholar 

  • McDonald, T. F., Pelzer, D., and Trautwein, W., (1984). J. Physiol. 352, 217–241.

    PubMed  Google Scholar 

  • McDonough, S. I., Lampe, R. A., Keith, R. A., and Bean, B. P., (1997a). Mol. Pharmacol. 52, 1095–1104.

    PubMed  Google Scholar 

  • McDonough, S. I., Mintz, I. M., and Bean, B. P., (1997b). Biophys. J. 72, 2117–2128.

    PubMed  Google Scholar 

  • McRory, J. E., Santi, C. M., Hamming, K. S., Mezeyova, J., Sutton, K. G., Baillie, D. L., Stea, A., and Snutch, T. P., (2001). J. Biol. Chem. 276, 3999–4011.

    PubMed  Google Scholar 

  • Meder, W. P., and Dooley, D. J., (2000). Brain Res. 875, 157–159.

    PubMed  Google Scholar 

  • Meunier, F. A., Feng, Z. P., Molgo, J., Zamponi, G. W., and Schiavo, G., (2002). Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulation N-type Ca2+ Channel activity., EMBO J. 21, 6733–6743.

    PubMed  Google Scholar 

  • Mikami, A., Imoto, K., Tanabe, T., Niidome, T., Mori, Y., Takeshima, H., Narumiya, S., and Numa, S., (1989). Nature, 340, 230–233.

    PubMed  Google Scholar 

  • Mintz, I. M., (1994). J. Neurosci. 14, 2844–2853.

    PubMed  Google Scholar 

  • Mintz, I. M., Venema, V. J., Adams, M. E., and Bean, B. P., (1991). Proc. Natl. Acad. Sci. U. S. A. 88, 6628–6631.

    PubMed  Google Scholar 

  • Mintz, I. M., Venema, V. J., Swiderek, K. M., Lee, T. D., Bean, B. P., and Adams, M. E., (1992). Nature, 355, 827–829.

    PubMed  Google Scholar 

  • Mlinar, B., and Enyeart, J. J., (1993). J. Physiol. 469, 639–652.

    PubMed  Google Scholar 

  • Monteil, A., Chemin, J., Bourinet, E., Mennessier, G., Lory, P., and Nargeot, J., (2000). J. Biol. Chem. 275, 6090–6100.

    PubMed  Google Scholar 

  • Mori, Y., Friedrich, T., Kim, M. S., Mikami, A., Nakai, J., Ruth, P., Bosse, E., Hofmann, F., Flockerzi, V., Furuichi, T., Mikoshiba, K., Imoto, K., Tanabe, T., and Numa, S., (1991). Nature, 350, 398–402.

    PubMed  Google Scholar 

  • Mouginot, D., Bossu, J. L., and Gahwiler, B. H., (1997). J. Neurosci. 17, 160–170.

    PubMed  Google Scholar 

  • Mulder, P., Richard, V., Compagnon, P., Henry, J. P., Lallemand, F., Clozel, J. P., Koen, R., Mace, B., and Thuillez, C., (1997). J. Am. Coll. Cardiol. 29, 416–421.

    PubMed  Google Scholar 

  • Mulder, P., Richard, V., and Thuillez, C., (1998). Cardiology 89 (Suppl. 1), 33–37.

    Google Scholar 

  • Newcomb, R., Palma, A., Fox, J., Gaur, S., Lau, K., Chung, D., Cong, R., Bell, J. R., Horne, B., Nadasdi, L., and Ramachandran, J., (1995). Biochemistry, 34, 8341–8347.

    PubMed  Google Scholar 

  • Newcomb, R., Szoke, B., Palma, A., Wang, G., Chen, X., Hopkins, W., Cong, R., Miller, J., Urge, L., Tarczy-Hornoch, K., Loo, J. A., Dooley, D. J., Nadasdi, L., Tsien, R. W., Lemos, J., and Miljanich, G., (1998). Biochemistry, 37, 15353–15362.

    PubMed  Google Scholar 

  • Nielsen, K. J., Thomas, L., Lewis, R. J., Alewood, P. F., and Craik, D. J., (1996). J. Mol. Biol. 263, 297–310.

    PubMed  Google Scholar 

  • Nishimura, S., Takeshima, H., Hofmann, F., Flockerzi, V., and Imoto, K., (1993). FEBS Lett. 324, 283–286.

    PubMed  Google Scholar 

  • Nowycky, M. C., Fox, A. P., and Tsien, R. W., (1985). Nature, 316, 440–443.

    PubMed  Google Scholar 

  • Olivera, B. M., Gray, W. R., Zeikus, R., McIntosh, J. M., Varga, J., Rivier, J., de Santos, V., and Cruz, L. J., (1985). Science, 230, 1338–1343.

    PubMed  Google Scholar 

  • Olivera, B. M., Miljanich, G. P., Ramachandran, J., and Adams, M. E., (1994). Annu. Rev. Biochem. 63, 823–867.

    PubMed  Google Scholar 

  • Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., van Eijk, R., Oefner, P. J., Hoffman, S. M., Lamerdin, J. E., Mohrenweiser, H. W., Bulman, D. E., Ferrari, M., Haan, J., Lindhout, D., van Ommen, G. J., Hofker, M. H., Ferrari, M. D., and Frants, R. R., (1996). Cell, 87, 543–552.

    PubMed  Google Scholar 

  • Pekel, M., Platt, B., and Busselberg, D., (1993). Brain Res. 632, 121–126.

    PubMed  Google Scholar 

  • Penn, R. D., and Paice, J. A., (2000). Pain, 85, 291–296.

    PubMed  Google Scholar 

  • Perchenet, L., and Clement-Chomienne, O., (2000). J. Pharmacol. Exp. Ther. 295, 771–778.

    PubMed  Google Scholar 

  • Perez-Reyes, E., Cribbs, L. L., Daud, A., Lacerda, A. E., Barclay, J., Williamson, M. P., Fox, M., Rees, M., and Lee, J. H., (1998). Nature, 391, 896–900.

    PubMed  Google Scholar 

  • Peters, T., Wilffert, B., Vanhoutte, P. M., and van Zwieten, P. A., (1991). J. Cardiovasc. Pharmacol. 18 (Suppl. 8), S1–S5.

    Google Scholar 

  • Peterson, B. Z., and Catterall, W. A., (1995). J. Biol. Chem. 270, 18201–18204.

    PubMed  Google Scholar 

  • Piser, T. M., Lampe, R. A., Keith, R. A., and Thayer, S. A., (1994). Pflugers Arch. 426, 214–220.

    PubMed  Google Scholar 

  • Piser, T. M., Lampe, R. A., Keith, R. A., and Thayer, S. A., (1995). Mol. Pharmacol. 48, 131–139.

    PubMed  Google Scholar 

  • Platzer, J., Engel, J., Schrott-Fischer, A., Stephan, K., Bova, S., Chen, H., Zheng, H., and Striessnig, J., (2000). Cell, 102, 89–97.

    PubMed  Google Scholar 

  • Prinz, H., and Striessnig, J., (1993). J. Biol. Chem. 268, 18580–18585.

    PubMed  Google Scholar 

  • Ragsdale, D. S., McPhee, J. C., Scheuer, T., and Catterall, W. A., (1994). Science, 265, 1724–1728.

    PubMed  Google Scholar 

  • Randall, A., and Tsien, R. W., (1995). J. Neurosci. 15, 2995–3012.

    PubMed  Google Scholar 

  • Ridgeway, B., Wallace, M., and Gerayli, A., (2000). Pain, 85, 287–289.

    PubMed  Google Scholar 

  • Romanin, C., Seydl, K., Glossmann, H., and Schindler, H., (1992). Pflugers Arch. 420, 410–412.

    PubMed  Google Scholar 

  • Romey, G., Bois, P., and Lazdunski, M., (1994). Eur. J. Pharmacol. 263, 101–105.

    PubMed  Google Scholar 

  • Romey, G., and Lazdunski, M., (1994). J. Pharmacol. Exp. Ther. 271, 1348–1352.

    PubMed  Google Scholar 

  • Roullet, J. B., Spaetgens, R. L., Burlingame, T., Feng, Z. P., and Zamponi, G. W., (1999). J. Biol. Chem. 274, 25439–25446.

    PubMed  Google Scholar 

  • Rousset, M., Cens, T., Restituito, S., Barrere, C., Black, J. L., III, McEnery, M. W., and Charnet, P., (2001). J. Physiol. 532, 583–593.

    PubMed  Google Scholar 

  • Roux, S., Buhler, M., and Clozel, J. P., (1996). J. Cardiovasc. Pharmacol. 27, 132–139.

    PubMed  Google Scholar 

  • Ryder, T. R., Hu, L. Y., Rafferty, M. F., Lotarski, S. M., Rock, D. M., Stoehr, S. J., Taylor, C. P., Weber, M. L., Miljanich, G. P., Millerman, E., and Szoke, B. G., (1999). Bioorg. Med. Chem. Lett. 9, 2453–2458.

    PubMed  Google Scholar 

  • Saegusa, H., Kurihara, T., Zong, S., Kazuno, A., Matsuda, Y., Nonaka, T., Han, W., Toriyama, H., and Tanabe, T., (2001). EMBO J. 20, 2349–2356.

    PubMed  Google Scholar 

  • Sah, D. W., and Bean, B. P., (1994). Mol. Pharmacol. 45, 84–92.

    PubMed  Google Scholar 

  • Santi, C. M., Cayabyab, F. S., Sutton, K. G., McRory, J. E., Mezeyova, J., Hamming, K. S., Parker, D., Stea, A., and Snutch, T. P., (2002). J. Neurosci. 22, 396–403.

    PubMed  Google Scholar 

  • Santi, C. M., Darszon, A., and Hernandez-Cruz, A., (1996). Am. J. Physiol. 271, C1583–C1593.

    PubMed  Google Scholar 

  • Sather, W. A., Tanabe, T., Zhang, J. F., Mori, Y., Adams, M. E., and Tsien, R. W., (1993). Neuron, 11, 291–303.

    PubMed  Google Scholar 

  • Schmid, A., Romey, G., Barhanin, J., and Lazdunski, M., (1989). Mol. Pharmacol. 35, 766–773.

    PubMed  Google Scholar 

  • Schweitz, H., Heurteaux, C., Bois, P., Moinier, D., Romey, G., and Lazdunski, M., (1994). Proc. Natl. Acad. Sci. U.S.A. 91, 878–882.

    PubMed  Google Scholar 

  • Seeman, P., and Lee, T., (1975). Science, 188, 1217–1219.

    PubMed  Google Scholar 

  • Seeman, P., Lee, T., Chau-Wong, M., and Wong, K., (1976). Nature, 261, 717–719.

    PubMed  Google Scholar 

  • Seydl, K., Kimball, D., Schindler, H., and Romanin, C., (1993). Pflugers Arch. 424, 552–554.

    PubMed  Google Scholar 

  • Sharp, A. H., Black, J. L., III, Dubel, S. J., Sundarraj, S., Shen, J. P., Yunker, A. M., Copeland, T. D., and McEnery, M. W., (2001). Neuroscience, 105, 599–617.

    PubMed  Google Scholar 

  • Sidach, S. S., and Mintz, I. M., (2000). J. Neurosci. 20, 7174–7182.

    PubMed  Google Scholar 

  • Sidach, S. S., and Mintz, I. M., (2002). J. Neurosci. 22, 2023–2034.

    PubMed  Google Scholar 

  • Sinnegger, M. J., Wang, Z., Grabner, M., Hering, S., Striessnig, J., Glossmann, H., and Mitterdorfer, J., (1997). J. Biol. Chem. 272, 27686–27693.

    PubMed  Google Scholar 

  • Snutch, T. P., Sutton, K. G., and Zamponi, G. W., (2001). Curr. Opin. Pharmacol. 1, 11–16.

    PubMed  Google Scholar 

  • Snutch, T. P., Tomlinson, W. J., Leonard, J. P., and Gilbert, M. M., (1991). Neuron, 7, 45–57.

    PubMed  Google Scholar 

  • Sokolov, S., Timin, E., and Hering, S., (2001). Circ. Res. 89, 700–708.

    PubMed  Google Scholar 

  • Sokolov, S., Weiss, R. G., Kurka, B., Gapp, F., and Hering, S., (1999). J. Physiol. 519 (Pt. 2), 315–322.

    PubMed  Google Scholar 

  • Soong, T. W., Stea, A., Hodson, C. D., Dubel, S. J., Vincent, S. R., and Snutch, T. P., (1993). Science, 260, 1133–1136.

    PubMed  Google Scholar 

  • Stea, A., Dubel, S. J., Pragnell, M., Leonard, J. P., Campbell, K. P., and Snutch, T. P., (1993). Neuropharmacology, 32, 1103–1116.

    PubMed  Google Scholar 

  • Stea, A., Soong, T. W., and Snutch, T. P., (1995). In Handbook of Receptors and Channels: Ligand-and Voltage-Gated Ion Channels: Voltage-Gated Calcium Channels (North, R. A., ed.), CRC Press, Boca Raton, Fl, pp. 113–152.

    Google Scholar 

  • Stea, A., Tomlinson, W. J., Soong, T. W., Bourinet, E., Dubel, S. J., Vincent, S. R., and Snutch, T. P., (1994a). Proc. Natl. Acad. Sci. U.S.A. 91, 10576–10580.

    PubMed  Google Scholar 

  • Stea, A., Tomlinson, W. J., Soong, T. W., Bourinet, E., Dubel, S. J., Vincent, S. R., and Snutch, T. P., (1994b). Proc. Natl. Acad. Sci. U.S.A. 91, 10576–10580.

    PubMed  Google Scholar 

  • Stocker, J. W., Nadasdi, L., Aldrich, R. W., and Tsien, R. W., (1997). J.Neurosci. 17, 3002–3013.

    PubMed  Google Scholar 

  • Stotz, S. C., Spaetgens, R. L., and Zamponi, G. W., (2000). J. Membr. Biol. 174, 157–165.

    PubMed  Google Scholar 

  • Striessnig, J., (1999). Cell Physiol. Biochem. 9, 242–269.

    PubMed  Google Scholar 

  • Striessnig, J., Glossmann, H., and Catterall, W. A., (1990). Proc. Natl. Acad. Sci. U.S.A. 87, 9108–9112.

    PubMed  Google Scholar 

  • Striessnig, J., Hering, S., Berger, W., Catterall, W. A., and Glossman, H., (1994). In Ion Channels in the Cardiovascular System: Function and Dysfunction: Calcium Antagonist Binding Domains of L-Type Calcium Channels (Spooner, P., ed.), pp. 441–458.

  • Striessnig, J., Murphy, B. J., and Catterall, W. A., (1991). Proc. Natl. Acad. Sci. U.S.A. 88, 10769–10773.

    PubMed  Google Scholar 

  • Strubing, C., Hering, S., and Glossman, H., (1993). Br. J. Pharmacol. 108, 884–891.

    PubMed  Google Scholar 

  • Suarez-Kurtz, G., and Kaczorowski, G. J., (1988). J. Pharmacol. Exp. Ther. 247, 248–253.

    PubMed  Google Scholar 

  • Sun, J., and Triggle, D. J., (1995). J. Pharmacol. Exp. Ther. 274, 419–426.

    PubMed  Google Scholar 

  • Sutton, K. G., Martin, D. J., Pinnock, R. D., Lee, K., and Scott, R. H., (2002). Br. J. Pharmacol. 135, 257–265.

    PubMed  Google Scholar 

  • Sutton, K. G., Siok, C., Stea, A., Zamponi, G. W., Heck, S. D., Volkmann, R. A., Ahlijanian, M. K., and Snutch, T. P., (1998). Mol. Pharmacol. 54, 407–418.

    PubMed  Google Scholar 

  • Takahashi, K., Ueno, S., and Akaike, N., (1991). J. Neurophysiol. 65, 148–155.

    PubMed  Google Scholar 

  • Tomlinson, W. J., Stea, A., Bourinet, E., Charnet, P., Nargeot, J., and Snutch, T. P., (1993). Neuropharmacology, 32, 1117–1126.

    PubMed  Google Scholar 

  • Tottene, A., Moretti, A., and Pietrobon, D., (1996). J. Neurosci. 16, 6353–6363.

    PubMed  Google Scholar 

  • Tsien, R. W., Ellinor, P. T., and Horne, W. A., (1991). Trends Pharmacol. Sci. 12, 349–354.

    PubMed  Google Scholar 

  • Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., and Fox, A. P., (1988). Trends Neurosci. 11, 431–438.

    PubMed  Google Scholar 

  • Turner, T. J., Lampe, R. A., and Dunlap, K., (1995). Mol. Pharmacol. 47, 348–353.

    PubMed  Google Scholar 

  • Vacher, E., Richer, C., Fornes, P., Clozel, J. P., (1996). J.Cardiovasc. Pharmacol. 27, 686–694.

    PubMed  Google Scholar 

  • Vanegas, H., and Schaible, H., (2000). Pain, 85, 9–18.

    PubMed  Google Scholar 

  • Viana, F., Van den, B. L., Missiaen, L., Vandenberghe, W., Droogmans, G., Nilius, B., and Robberecht, W., (1997). Cell Calcium, 22, 299–311.

    PubMed  Google Scholar 

  • Wang, L., Bhattacharjee, A., Fu, J., and Li, M., (1996). Diabetes, 45, 1678–1683.

    PubMed  Google Scholar 

  • Wang, Y. X., Pettus, M., Gao, D., Phillips, C., and Scott, B. S., (2000). Pain, 84, 151–158.

    PubMed  Google Scholar 

  • Wappl, E., Koschak, A., Poteser, M., Sinnegger, M. J., Walter, D., Eberhart, A., Groschner, K., Glossmann, H., Kraus, R. L., Grabner, M., and Striessnig, J., (2002). J. Biol. Chem. 277, 6960–6966.

    PubMed  Google Scholar 

  • Wappl, E., Mitterdorfer, J., Glossmann, H., and Striessnig, J., (2001). J.Biol. Chem. 276, 12730–12735.

    PubMed  Google Scholar 

  • Watanabe, T., Kalasz, H., Yabana, H., Kuniyasu, A., Mershon, J., Itagaki, K., Vaghy, P. L., Naito, K., Nakayama, H., and Schwartz, A., (1993). FEBS Lett. 334, 261–264.

    PubMed  Google Scholar 

  • Weinberger, M. H., (1992). Am. J. Cardiol. 69, 13E-16E.

    PubMed  Google Scholar 

  • Weinsberg, F., Bickmeyer, U., and Wiegand, H., (1994). Neuropharmacology, 33, 885–890.

    PubMed  Google Scholar 

  • Westenbroek, R. E., Hell, J. W., Warner, C., Dubel, S. J., Snutch, T. P., and Catterall, W. A., (1992). Neuron, 9, 1099–1115.

    PubMed  Google Scholar 

  • Westenbroek, R. E., Sakurai, T., Elliott, E. M., Hell, J. W., Starr, T. V., Snutch, T. P., and Catterall, W. A., (1995). J. Neurosci. 15, 6403–6418.

    PubMed  Google Scholar 

  • Wheeler, D. B., Randall, A., and Tsien, R. W., (1994). Science, 264, 107–111.

    PubMed  Google Scholar 

  • Williams, M. E., Brust, P. F., Feldman, D. H., Patthi, S., Simerson, S., Maroufi, A., McCue, A. F., Velicelebi, G., Ellis, S. B., and Harpold, M. M., (1992a). Science, 257, 389–395.

    PubMed  Google Scholar 

  • Williams, M. E., Feldman, D. H., McCue, A. F., Brenner, R., Velicelebi, G., Ellis, S. B., and Harpold, M. M., (1992b). Neuron, 8, 71–84.

    PubMed  Google Scholar 

  • Williams, M. E., Marubio, L. M., Deal, C. R., Hans, M., Brust, P. F., Philipson, L. H., Miller, R. J., Johnson, E. C., Harpold, M. M., and Ellis, S. B., (1994). J. Biol. Chem. 269, 22347–22357.

    PubMed  Google Scholar 

  • Wilson, S. M., Toth, P. T., Oh, S. B., Gillard, S. E., Volsen, S., Ren, D., Philipson, L. H., Lee, E. C., Fletcher, C. F., Tessarollo, L., Copeland, N. G., Jenkins, N. A., and Miller, R. J., (2000). J. Neurosci. 20, 8566–8571.

    PubMed  Google Scholar 

  • Winterfield, J. R., and Swartz, K. J., (2000). J. Gen. Physiol. 116, 637–644.

    PubMed  Google Scholar 

  • Woppmann, A., Ramachandran, J., and Miljanich, G. P., (1994). Mol. Cell Neurosci. 5, 350–357.

    PubMed  Google Scholar 

  • Xu, W., and Lipscombe, D., (2001). J. Neurosci. 21, 5944–5951.

    PubMed  Google Scholar 

  • Yamaguchi, S., Okamura, Y., Nagao, T., and Adachi-Akahane, S., (2000). J. Biol. Chem. 275, 41504–41511.

    PubMed  Google Scholar 

  • Zamponi, G. W., (1997). Drug Development Research, 42, 131–143.

    Google Scholar 

  • Zamponi, G. W., (1999). J. Membr. Biol. 167, 183–192.

    PubMed  Google Scholar 

  • Zamponi, G. W., Bourinet, E., and Snutch, T. P., (1996a). J. Membr. Biol. 151, 77–90.

    PubMed  Google Scholar 

  • Zamponi, G. W., Soong, T. W., Bourinet, E., and Snutch, T. P., (1996b). J. Neurosci. 16, 2430–2443.

    PubMed  Google Scholar 

  • Zhang, J. F., Randall, A. D., Ellinor, P. T., Horne, W. A., Sather, W. A., Tanabe, T., Schwarz, T. L., and Tsien, R. W., (1993). Neuropharmacology, 32, 1075–1088.

    PubMed  Google Scholar 

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  1. Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr. NW, Calgary, Canada, T2N 4N1

    Clinton J. Doering & Gerald W. Zamponi

  2. Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Dr. NW, Calgary, Canada, T2N 4N1

    Clinton J. Doering & Gerald W. Zamponi

  3. NeuroMed Technologies Inc., Vancouver, Canada

    Clinton J. Doering

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Doering, C.J., Zamponi, G.W. Molecular Pharmacology of High Voltage-Activated Calcium Channels. J Bioenerg Biomembr 35, 491–505 (2003). https://doi.org/10.1023/B:JOBB.0000008022.50702.1a

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