Skip to main content
Log in

Development and cell response of a new biodegradable composite scaffold for guided bone regeneration

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Composites of biodegradable polymers with different calcium phosphate ceramics and glasses, have been developed as scaffolds for applications in bone–tissue engineering. In this work, phosphate glass particles have been incorporated into the polymer, poly(95L/5DL) lactic acid (PLA) and porous structures were elaborated. Their porosity, compressive mechanical properties and biological response were evaluated. Interconnected structures with evenly distributed pores and a porosity as high as 97% were obtained. The incorporation of glass particles into the polymer showed to have a positive effect in the mechanical properties of the foams. Indeed, the compressive modulus increased from 74.5 to 120 KPa and the compressive strength from 17.5 to 20.1 KPa for the PLA and the PLA/glass foams, respectively. The biological response was evaluated by means of the MTT test, the materials resulted to be noncytotoxic.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. A. Roether, A. R. Boccaccini, L. Hench, V. Maquet, S. Gautier and R. Jerome, Biomaterials 23 (2002) 3871.

    Google Scholar 

  2. Z. Xiong, Y. Yan, S. Wang, R. Zhang and C. Zhang, Script. Mater. 46 (2002) 771.

    Google Scholar 

  3. L. G. Griffith, Acta Mater. 48 (2000) 263.

    Google Scholar 

  4. D. W. Hutmacher, Biomaterials 21 (2000) 2529.

    Google Scholar 

  5. M. Vert, P. Christel, F. Chabot and J. Leray, in “Macromolecular Biomaterials” (CRC Press, Boca Raton, 1984) p. 119.

    Google Scholar 

  6. J. Burnie, T. Gilchrist, S. R. I. Duff, C. F. Drake, N. G. Harding and A. J. Malcolm, Biomaterials 2 (1981) 244.

    Google Scholar 

  7. J. Vogel, P. Wange and P. Hartmann, Glasstech. VerGlass Sci. Tech. 70 (1997) 220.

    Google Scholar 

  8. K. Franks, I. Abrahams and J. C. Knowles, J. Mater. Sci. Mater. Med. 11 (2000) 609.

    Google Scholar 

  9. J. Clement, L. Eckeberg, S. Martinez, M. P. Ginebra, F. J. Gil and J. A. Planell, in “Proceedings of the 11th International Symposium on Ceramics in Medicine”, edited by R. Le Geros and J. P. Le Geros (New York, November, 1998) p. 141.

  10. M. Navarro, M. P. Ginebra, S. Martinez, G. Avila and J. A. Planell, J. Am. Ceram. Soc. 86 (2003) 1354.

    Google Scholar 

  11. M. Navarro, M. P. Ginebra and J. A. Planell, J. Biomed. Mater. Res. (in press).

  12. Q. Hou, D. Grijpms and J. Feijen, Biomaterials 24 (2003) 1937.

    Google Scholar 

  13. L. Gibson and M. Ashby, in “Cellular Solids” (Cambridge University Press, 1997) p. 175.

  14. R. E. Holmes, Plast. Reconstr. Surg. 63 (1979) 626.

    Google Scholar 

  15. O. Gauthier, J. M. Bouler, E. Aguado, P. Pilet and G. Daculsi, Biomaterials 19 (1998) 133.

    Google Scholar 

  16. J. Bobyn, R. Pilliar, H. Cameron and G. Weatherly, Clin. Orthop. Rel. Res. 150 (1980) 263.

    Google Scholar 

  17. Q. Hou, Biomaterials 24 (2003) 1937.

    Google Scholar 

  18. C. J. Spaans, V. W. Belgraver, O. Rienstra, J. H. De Groot, R. P. H. Veth and A. J. Pennings, ibid. 21 (2000) 2453.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to M. P. Ginebra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Navarro, M., Ginebra, M.P., Planell, J.A. et al. Development and cell response of a new biodegradable composite scaffold for guided bone regeneration. Journal of Materials Science: Materials in Medicine 15, 419–422 (2004). https://doi.org/10.1023/B:JMSM.0000021113.88702.9d

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/B:JMSM.0000021113.88702.9d

Keywords

Navigation