Abstract
Purpose : Vaginal progesterone administration starting on the day of oocyte retrieval induced a decrease in uterine contraction frequency on the day of embryo transfer (ET) as compared with preovulatory values. Uterine relaxation before ET is likely to improve outcome by avoiding displacement of the embryo from the uterine cavity (Fanchin, Righini, de Ziegler, Oliviennes, Ledée, Frydman: Fertil Steril 2001;75:1136–1140). The objective of the present study was to determine whether the early use of vaginal progesterone on the day of oocyte retrieval may alter the embryo implantation and pregnancy rates.
Methods : A total of 103 patients were submitted for ovarian stimulation with GnRH-a and recombinant FSH (Puregon, Organon) for the application of invasive assisted reproduction techniques (ICSI). The patients were divided into two groups in a prospective and randomized manner: Group A (n = 51) where application of vaginal progesterone started (Utrogestan, Besins International) at the dose of 400 mg from the evening of the day of oocyte retrieval, and Group B (n = 52) started to apply vaginal progesterone at the same dose but from the evening of embryo transfer (2nd day).
Results : The age of Group A patients (34.2 ± 4.6) was similar (p = 0.50) to that of Group B patients (34.8 ± 4.9). The number of oocytes retrieved and at metaphase II from Group A patients (10.6 ± 6.9 and 7.8 ± 6.0; respectively) did not differ significantly (p = 0.84 and p = 0.49, respectively) from the number of oocytes retrieved and metaphase II from Group B patients (10 ± 5.6 and 6.7 ± 4.7, respectively). Also, there was no difference (p = 0.48) in number of embryos transferred to Group A patients (2.7 ± 0.8) versus Group B patients (2.7 ± 0.9). Embryo implantation and pregnancy rates for Group A patients (12.6 and 27.4%, respectively) were equal (p = 0.98 and p = 1.0, respectively) to those for Group B patients (13.4 and 28.8%, respectively).
Conclusion : Vaginal progesterone at the dose of 400 mg started on the day of oocyte retrieval did not increase implantation or pregnancy rates when compared to the same dose started on the day of embryo transfer.
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REFERENCES
Chnatilis SJ, Zeitoun KM, Patel SI, Johns DA, Madziar VA, McIntire DD: Use of crinone vaginal progesterone gel for luteal support in in vitro fertilization cycles. Fertil Steril 1999;72:823–829
Sohn SH, Penzias AS, Emmi AM, Dukey AK, Layman LC, Reindollar RH: Administration of progesterone before oocyte retrieval negatively affects the implantation rate. Fertil Steril 1999;71:11–14
Fanchin R, Righini C, Oliviennes F, Taylor S, de Ziegler D, Frydman R: Uterine contractions at the time of embryo transfer alter pregnancy rates after in vitro fertilization. Hum Reprod 1998;13:1968–1974
Fanchin R, Righini C, de Ziegler D, Oliviennes F, Ledée N, Frydman R: Effects of vaginal progesterone administration on uterine contractility at the time of embryo transfer. Fertil Steril 2001;75:1136–1140
Franco JG Jr, Baruffi RLR, Coelho J et al: Prospective randomized comparison of ovarian blockade with nafarelin versus leuprolide during ovarian stimulation with recombinant FSH in an ICSI program. J Assist Reprod Genet 2001;18:593–597
Svalander P, Forsberg AS, Jakobsson AH, Wikland M: Factors of importance for the establishment of a successful program of intracytoplasmic sperm injection treatment for male infertility. Fertil Steril 1995;63:828–837
Fanchin R, Ayoubi JM, Olivennes F, Righini C, de Ziegler D, Frydman R: Hormonal influence on the uterine contractility during ovarian stimulation. Hum Reprod 2000;15(Suppl 1):90–100
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Baruffi, R., Mauri, A.L., Petersen, C.G. et al. Effects of Vaginal Progesterone Administration Starting on the Day of Oocyte Retrieval on Pregnancy Rates. J Assist Reprod Genet 20, 517–520 (2003). https://doi.org/10.1023/B:JARG.0000013653.54830.2c
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DOI: https://doi.org/10.1023/B:JARG.0000013653.54830.2c