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Inhibition of mouse liver lipid peroxidation by high molecular weight phlorotannins from Sargassum kjellmanianum

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Abstract

The inhibitory effects of high molecularweight phlorotannins (HMP) from Sargassum kjellmanianum on mouse liverlipid peroxidation were investigated byspectrophotometric methods. The content ofmalondialdehyde (MDA) in liver samples wasmeasured by TBA (thiobarbituric acid)assay. It showed that HMP significantlyinhibited the generation of MDA invivo and in situations induced byCCl4 and Fe2+-Vc (ascorbic acid),and significantly decreased membraneswelling of mouse liver mitochondria,compared with controls (p<0.01). HMP werefound to have strong anti-oxidativeactivity in inhibiting mouse liver lipidperoxidation.

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Authors and Affiliations

  1. Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, P.R. China

    Yuxi Wei, Zhi'en Li & Zuhong Xu

  2. The Graduate School, Chinese Academy of Sciences, Beijing, 100039, P.R. China

    Yuxi Wei

  3. Biological Department, Qingdao University, Qingdao, 266071, P.R. China

    Yuxi Wei & Yingfen Hu

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  1. Yuxi Wei
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  2. Zhi'en Li
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Wei, Y., Li, Z., Hu, Y. et al. Inhibition of mouse liver lipid peroxidation by high molecular weight phlorotannins from Sargassum kjellmanianum . Journal of Applied Phycology 15, 507–511 (2003). https://doi.org/10.1023/B:JAPH.0000004344.45697.0f

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  • DOI: https://doi.org/10.1023/B:JAPH.0000004344.45697.0f

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