Abstract
Sulfotransferase 1A1 (SULT1A1), also designated as phenol-preferring sulfotransferase, is involved in the bioactivation and detoxification of a variety of potential carcinogens, including iodothyronines, hydroxylated aromatic amines, and phenolic xenobiotics. A common arginine (R) to histidine (H) polymorphism at amino acid position 213 influences SULT1A1 activity and has been suggested as risk factor for a different types of cancers. To investigate the role of this polymorphism for breast cancer risk, SULT1A1 genotype was determined in 500 women with clinically verified breast cancer and 500 female age-matched healthy control subjects. Frequencies of heterozygous (controls: 42.5% patients: 50.2%) or homozygous (controls: 12.6%; patients: 9.4%) carriers of the 213H variant were not significantly different between groups.ficantly different between groups. The SULT1A1 genotype was furthermore not associated with tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. The SULT1A1 213H variant was associated with the presence of lymph node metastases (p = 0.002). We conclude that the SULT1A1 R213H polymorphism is not a general risk factor for breast cancer, but may be involved in lymph node metastazing in breast cancer patients.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
El-Bayoumy K: Environmental carcinogens that may be involved in human breast cancer etiology. Chem Res Toxicol 5:570–585, 1992
Williams JA, Stone EM, Fakis G, Johnson N, Cordell JA, Meinl W, Glatt H, Sim E, Phillips DH: N-Acetyltransfe-rases, sulfotransferases and heterocyclic amine activation in the breast. Pharmacogenetics 11:373–388, 2001
Glatt H: Bioactivation of mutagens via sulfation. FASEB J 11:314–321, 1997
Nagata K, Yamazoe Y: Pharmacogenetics of sulfotrans-ferase. Annu Rev Pharmacol Toxicol 40:159–176, 2000
Dooley TP: Cloning of the human phenol sulfotransferase gene family: three genes implicated in the metabolism of catecholamines, thyroid hormones and drugs. Chem Biol Interact 109:29–41, 1998
Raftogianis RB, Wood TC, Weinshilboum RM: Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype phenotype correlations. Biochem Pharmacol 58: 605–616, 1999
Glatt H, Meinl W: Pharmacogenetics of soluble sul-fotransferases (SULTs). Naunyn Schmiedebergs Arch Pharmacol 369:55–68, 2004
Zheng W, Xie D, Cerhan JR, Sellers TA, Wen W, Folsom AR: Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10:89–94, 2001
Tang D, Rundle A, Mooney L, Cho S, Schnabel F, Estabrook A, Kelly A, Levine R, Hibshoosh H, Perera F: Sulfotransferase 1A1 (SULT1A1)polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case–control study. Breast Cancer Res Treat 78:217–222, 2003
Krippl P, Langsenlehner U, Renner W, Yazdani-Biuki B, Wolf G, Wascher T.C, Paulweber B, Haas J, Samonigg H: A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk. Int J Cancer 106:468–471, 2003
Langsenlehner U, Krippl P, Renner W, Yazdani-Biuki B, Wolf G, Wascher T.C, Paulweber B, Weitzer W, Samonigg H: The common 677C >T gene polymorphism of methylenetetrahydrofolate reductase gene is not asso-ciated with breast cancer risk. Breast Cancer Res Treat 81: 169–172, 2003
Krippl P, Langsenlehner U, Renner W, Yazdani-Biuki B., Wolf G, Wascher T.C, Paulweber B, Bahadori B, Samonigg H: The L10P polymorphism of the transforming growth factor-beta 1 gene is not associated with breast cancer risk. Cancer Lett 201:181–184, 2003
Krippl, P, Langsenlehner, U, Renner, W, Yazdani-Biuki B, Wolf G, Wascher T.C, Paulweber B, Weitzer W, Leithner A, Samonigg H: The 870G >A polymorphism of the Cyclin D1 gene is not associated with breast cancer. Breast Cancer Res Treat 82:165–168, 2003
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Langsenlehner, U., Krippl, P., Renner, W. et al. Genetic Variants of the Sulfotransferase 1A1 and Breast Cancer Risk. Breast Cancer Res Treat 87, 19–22 (2004). https://doi.org/10.1023/B:BREA.0000041574.90735.ea
Issue Date:
DOI: https://doi.org/10.1023/B:BREA.0000041574.90735.ea