Abstract
The heme-containing protein myeloperoxidase is released from stimulated polymorphonuclear leukocytes at sites of inflammation. It is involved in the generation of reactive oxygen and nitrogen species and tissue damage. The general properties and functional aspects of this enzyme are reviewed. Special attention is given to luminescence methods for investigating the release of myeloperoxidase from stimulated cells.
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REFERENCES
Fantone, J. C., and Ward, P. A. (1982)Am. J. Pathol.,107, 397–418.
Allen, R. C., and Stevens, D. L. (1992)Curr. Opin. Infect. Dis.,5, 389–398.
Edwards, S. W. (1994)Biochemistry and Physiology of the Neutrophil, Cambridge University Press.
Borregaard, N., Miller, L. J., and Springer, T. A. (1987)Science,237, 1204–1206.
Sengeloev, H., Kjeldsen, L., and Borregaard, N. (1993)J. Immunol.,150, 1535–1543.
Babior, B. M., Kipnes, R. S., and Curnutte, J. T. (1973)J. Clin. Invest.,52, 741–744.
Segal, A. W., and Abo, A. (1993)Trends Biochem. Sci.,18, 43–47.
Carlson, M. G. C., Peterson, C. G. B., and Venge, P. (1985)J. Immunol.,134, 1875–1879.
Sakamaki, K., Tomonaga, M., Tsukui, K., and Nagata, S. (1989)J. Biol. Chem.,264, 16828–16836.
Nauseef, W. M., and Malech, H. L. (1986)Blood,67, 1504–1507.
Andrews, P. C., Parnes, C., and Krinsky, N. I. (1984)Arch. Biochem. Biophys.,228, 439–442.
Fiedler, T. J., Davey, C. A., and Fenna, R. E. (2000)J. Biol. Chem.,275, 11964–11971.
Kettle, A. J., and Winterbourn, C. C. (1994)J. Biol. Chem.,269, 17146–17151.
Furtmueller, P. G., Burner, U., Jantschko, W., Regelsberger, G., and Obinger, C. (2000)FEBS Lett.,484, 139–143.
Floris, R., and Wever, R. (1992)Eur. J. Biochem.,207, 697–702.
Furtmueller, P. G., Burner, U., Jantschko, W., Regelsberger, G., and Obinger, C. (2000)Redox Report,5, 173–178.
Dolphin, D., and Felton, R. H. (1974)Acc. Chem. Res.,7, 26.
Van Dalen, C. J., Whitehouse, M. W., Winterbourn, C. C., and Kettle, A. J. (1997)Biochem. J.,327, 487–492.
Marquez, L. A., and Dunford, H. B. (1995)J. Biol. Chem.,270, 30434–30440.
Burner, U., Jantschko, W., and Obinger, C. (1999)FEBS Lett.,443, 290–296.
Burner, U., Furtmueller, P. G., Kettle, A. J., Koppenol, W. H., and Obinger, C. (2000)J. Biol. Chem.,275, 20597–20601.
Abu-Soud, H. M., and Hazen, S. L. (2000)J. Biol. Chem.,275, 37524–37532.
Podrez, E. A., Abu-Soud, H. M., and Hazen, S. L. (2000)Free Rad. Biol. Med.,28, 1717–1725.
Zgliczynski, J. M., Selvaraj, R. J., Paul, B. B., Stelmazynska, T., Poskitt, P. K. F., and Sbarra, A. J. (1977)Proc. Soc. Exp. Biol. Med.,154, 418–422.
Bakkenist, A. R. J., De Boer, J. E. G., Plat, H., and Wever, R. (1980)Biochim. Biophys. Acta,613, 337–348.
Held, A. M., Halko, D. J., and Hurst, J. K. (1978)J. Am. Chem. Soc.,100, 5732–5740.
Candeias, L. P., Patel, K. B., Stratford, M. R. L., and Wardman, P. (1993)FEBS Lett.,333, 151–153.
Ramos, C. L., Pou, S., Britigan, B. E., Cohen, M. S., and Rosen, G. M. (1992)J. Biol. Chem.,267, 8307–8312.
Osipov, A. N., Yakutova, E. S., and Vladimirov, J. A. (1993)Biofizika,38, 383–388.
Wardman, P., and Candeias, L. P. (1996)Rad. Res.,145, 523–531.
Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., and van der Vliet, A. (1998)Nature,391, 393–397.
Arnhold, J., Furtmueller, P. G., Regelsberger, G., and Obinger, C. (2001)Eur. J. Biochem.,268, 5142–5148.
Furtmueller, P. G., Arnhold, J., Jantschko, W., Pichler, H., and Obinger, C. (2003)Biochem. Biophys. Res. Commun.,301, 551–557.
Winterbourn, C. C. (1985)Biochim. Biophys. Acta,840, 204–210.
Arnhold, J., Mueller, S., Arnold, K., and Sonntag, K. (1993)J. Biolum. Chemilum.,8, 307–313.
Thomas, E. L., Jefferson, M. M., and Grisham, M. B. (1982)Biochemistry,21, 6299–6308.
Test, S. T., Lambert, M. B., Ossanna, P. J., Thoene, J. G., and Weiss, S. J. (1982)J. Clin. Invest.,74, 1341–1349.
Johansson, M. W., Patarroyo, M., Oeberg, F., Siegbahn, A., and Nilsson, K. (1997)J. Cell Sci.,110, 1133–1139.
Arnhold, J., Osipov, A. N., Spalteholz, H., Panasenko, O. M., and Schiller, J. (2001)Free Rad. Biol. Med.,9, 1111–1119.
Arnhold, J., Osipov, A. N., Spalteholz, H., Panasenko, O. M., and Schiller, J. (2002)Biochim. Biophys. Acta,1572, 91–100.
Panasenko, O. M., Spalteholz, H., Schiller, J., and Arnhold, J. (2003)Free Rad. Biol. Med.,34, 553–562.
Panasenko, O. M., Arnhold, J., Vladimirov, J. A., Arnold, K., and Sergienko, V. I. (1997)Free Rad. Res.,27, 1–12.
Panasenko, O. M., and Arnhold, J. (1999)Free Rad. Res.,30, 479–487.
Heinecke, J. W., Li, W., Francis, G. A., and Goldstein, J. A. (1993)J. Clin. Invest.,91, 2866–2872.
Savenkova, M. L., Mueller, D. M., and Heinecke, J. W. (1994)J. Biol. Chem.,269, 20394–20400.
Biasucci, L. M., D'Onofrio, G., Liuzzi, G., Zini, G., Monaco, C., Caligiuri, G., Tommasi, M., Rebuzzi, A. G., and Maseri, A. (1996)J. Am. Coll. Cardiol.,27, 611–616.
Deby-Dupont, G., Deby, C., and Lamy, M. (1999)Intensivmedizin Notfallmedizin,36, 500–513.
Daphna, E. M., Michaela, S., Eynat, P., Irit, A., and Rimon, S. (1998)Mol. Cell Biochem.,183, 55–61.
Baldus, S., Eiserich, J. P., Mani, A., Castrom, L., Figueroa, M., Chumley, P., Ma, W., Tousson, A., White, R., Bullard, D. C., Brennan, M.-L., Lusis, A. J., Moore, K. P., and Freeman, B. A. (2001)J. Clin. Invest.,108, 1759–1770.
Cuzzocrea, S., Costantino, G., Mazzon, E., and Caputi, A. P. (1999)Crit. Care Med.,27, 1524–1532.
Van der Vliet, A., Nguyen, M. N., Shigenaga, M. K., Eiserich, J. P., Marelich, G. P., and Cross, C. E. (2000)Am. J. Physiol. Lung Cell. Mol. Physiol.,279, L537–L546.
Baldus, S., Eiserich, J. P., Brennan, M.-L., Jackson, R. M., Alexander, C. B., and Freeman, B. A. (2002)Free Rad. Biol. Med.,33, 1010–1019.
Eiserich, J. P., Baldus, S., Brennan, M.-L., Ma, W., Zhang, C., Tousson, A., Castro, L., Lusis, A. J., Nauseef, W. M., White, C. R., and Freeman, B. A. (2002)Science,296, 2391–2394.
Nauseef, W. M. (1988)Hematol. Oncol. Clin. North Am.,2, 135–158.
Rosen, H., and Klebanoff, S. (1976)J. Clin. Invest.,58, 50–60.
Stendahl, O., Coble, B.-I., Dahlgren, C., Hed, J., and Molin, L. (1984)J. Clin. Invest.,73, 366–373.
Podrez, E. A., Schmitt, D., Hoff, H. F., and Hazen, S. L. (1999)J. Clin. Invest.,103, 1547–1560.
Nagra, R., Becher, B., Tourtellotte, W. W., Antel, J. P., Gold, D., and Palidino, T. (1997)Neuroimmunology,78, 97–107.
Reynolds, W. F., Rhees, J., Maciejewski, D., Paladino, T., Sieburg, H., Maki, R. A., and Masliah, E. (1999)Exp. Neurol.,155, 31–41.
Jolivalt, C., Leininger-Muller, B., Drozdz, R., Naskalski, J. W., and Siest, G. (1996)Neurosci. Lett.,210, 61–64.
Daugherty, A., Dunn, J. L., Rateri, D. L., and Heinecke, J. W. (1994)J. Clin. Invest.,94, 437–444.
Malle, E., Waeg, G., Schreiber, R., Grone, E. F., Sattler, W., and Grone, H. J. (2000)Eur. J. Biochem.,267, 4495–4503.
Nakajima, K., Powers, J. C., Ashe, B. M., and Zimmermann, M. (1979)J. Biol. Chem.,254, 4027–4032.
Allen, R. C., Stjernholm, R. L., and Steele, R. H. (1972)Biochem. Biophys. Res. Commun.,47, 679–684.
Baxendale, J. H. (1973)J. Chem. Soc. Faraday Trans. I,69, 1665–1677.
Eriksen, T. E., Lind, J., and Meroenyi, G. (1981)J. Chem. Soc. Faraday Trans. I,77, 2125–2135.
Meroenyi, G., Lind, J., and Eriksen, T. E. (1990)J. Biolum. Chemilum.,5, 53–56.
Meroenyi, G., Lind, J., and Eriksen, T. E. (1986)J. Am. Chem. Soc.,108, 7716–7726.
Dahlgren, C., and Stendahl, O. (1982)Infect. Immun.,39, 34–39.
Dahlgren, C. (1989)Free Rad. Biol. Med.,6, 399–403.
Radi, R., Cosgrove, T. P., Beckamn, J. S., and Freeman, B. A. (1993)Biochem. J.,290, 51–57.
Fukuyama, N., Ichimori, K., Su, Z., Ishida, H., and Nakazawa, H. (1996)Biochem. Biophys. Res. Commun.,224, 414–419.
Henry, J. P., and Michelson, A. M. (1973)Biochimie,55, 83–93.
Roberts, P. A., Knight, J., and Campbell, A. K. (1987)Analyt. Biochem.,160, 139–148.
Dunstan, S. L., Sala-Newby, G. B., Fajardo, A. B., Taylor, K. M., and Campbell, A. K. (2000)J. Biol. Chem.,275, 9403–9409.
Reichl, S., Arnhold, J., Knight, J., Schiller, J., and Arnold, K. (2000)Free Rad. Biol. Med.,28, 1555–1563.
Wittko-Sarsat, V., Nguyen, A. T., Knight, J., and Descamps-Latscha, B. (1992)Free Rad. Biol. Med.,13, 83–88.
Reichl, S., Vocks, A., Petkovich, M., Schiller, J., and Arnhold, J. (2001)Free Rad. Res.,35, 723–733.
Kettle, A. J., and Winterbourn, C. C. (1994)Meth. Enzymol.,233, 502–512.
Klebanoff, S. J., Waltersdorph, A. M., and Rosen, H. (1984)Meth. Enzymol.,105, 399–403.
Voetman, A. A., Weening, R. S., Hamers, M. N., Meerhof, L. J., Bot, A. M., and Roos, D. (1981)J. Clin. Invest.,67, 1541–1549.
Edwards, S. W., Say, J. E., Taylor, J., and Hart, C. A. (1988)J. Clin. Lab. Immunol.,27, 97–102.
Bach, M. K., Brashler, J. R., Sanders, M. E., and Bienkowski, M. J. (1991)J. Immunol. Meth.,142, 243–250.
King, C. C., Jefferson, M. M., and Thomas, E. L. (1997)J. Leukoc. Biol.,61, 293–302.
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Arnhold, J. Properties, Functions, and Secretion of Human Myeloperoxidase. Biochemistry (Moscow) 69, 4–9 (2004). https://doi.org/10.1023/B:BIRY.0000016344.59411.ee
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DOI: https://doi.org/10.1023/B:BIRY.0000016344.59411.ee