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Effect of plasma micronutrients on clearance of oncogenic human papillomavirus (HPV) infection (United States)

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Abstract

Objective: Data have suggested that higher levels of nutrients are protective against HPV persistence and cervical neoplasia. This study assessed the role of circulating nutrients on clearance of oncogenic HPV infections. Methods: Women were followed prospectively with visits at baseline and approximately 4- and 10-months post-baseline. At each visit, 15 oncogenic HPV types were determined. Plasma levels were assessed at the 4-month visit for retinol, carotenoids (i.e., α-, trans-β-, cis-β-carotene, α-, β-cryptoxanthin, lutein, zeaxanthin, trans- and cis-lycopene), tocopherols (i.e., α-, δ-, and γ-tocopherol), folate and vitamin B12. Using multivariate Cox proportional hazards models, time to clearance analyses of oncogenic HPV infections were conducted for 84 women with at least one oncogenic infection at baseline. Hazard ratios (HR) were estimated for the association of HPV clearance to each nutrient tertile and to determine linear trends. Results: The likelihood of clearing an oncogenic HPV infection was significantly higher with increasing levels of trans-lycopene (p for trend, 0.025) and cis-lycopene (p for trend, 0.010). The adjusted hazard ratios of the highest tertiles of trans- and cis-lycopene were 2.79 (95% CI = 1.17–6.66) and 2.92 (95% CI = 1.28–6.63) compared with the lowest tertiles. Conclusions: Higher concentrations of trans- and cis-lycopene may reduce the time to clearance of an oncogenic HPV infection.

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References

  1. Parkin DM, Pisani P, Ferlay J (1999) Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 80: 827-841.

    Google Scholar 

  2. Franco EL (1996) Epidemiology of anogenital warts and cancer. Obstet Gynecol Clin North Am 23: 597-623.

    Google Scholar 

  3. Bosch FX, Manos MM, Munoz N, et al. (1995) Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) study group. J Natl Cancer Inst 87: 796-802.

    Google Scholar 

  4. Walboomers JM, Jacobs MV, Manos MM, et al. (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189: 12-19.

    Google Scholar 

  5. Moscicki AB, Palefsky J, Smith G, Siboshski S, Schoolnik G (1993) Variability of human papillomavirus DNA testing in a longitudinal cohort of young women. Obstet Gynecol 82: 578-585.

    Google Scholar 

  6. Wheeler CM, Greer CE, Becker TM, Hunt WC, Anderson SM, Manos MM (1996) Short-term fluctuations in the detection of cervical human papillomavirus DNA. Obstet Gynecol 88: 261-268.

    Google Scholar 

  7. Ho GY, Bierman R, Beardsley L, Chang CJ, Burk RD (1998) Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338: 423-428.

    Google Scholar 

  8. Schlecht NF, Kulaga S, Robitaille J, et al. (2001) Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. J Am Med Assoc 286: 3106-3114.

    Google Scholar 

  9. Schiffman MH, Brinton LA (1995) The epidemiology of cervical carcinogenesis. Cancer 76: 1888-1901.

    Google Scholar 

  10. Giuliano AR, Papenfuss M, Nour M, Canfield LM, Schneider A, Hatch K (1997) Antioxidant nutrients: associations with persistent human papillomavirus infection. Cancer Epidemiol Biomarkers Prev 6: 917-923.

    Google Scholar 

  11. Sedjo RL, Inserra P, Abrahamsen M, et al. (2002) Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. Cancer Epidemiol Biomarkers Prev 11: 353-359.

    Google Scholar 

  12. Sedjo RL, Roe DJ, Abrahamsen M, et al. (2002) Vitamin A, carotenoids and risk of persistent oncogenic human papillomavirus infection. Cancer Epidemiol Biomarkers Prev 11: 876-884.

    Google Scholar 

  13. Palan PR, Chang CJ, Mikhail MS, Ho GY, Basu J, Romney SL (1998) Plasma concentrations of micronutrients during a ninemonth clinical trial of beta-carotene in women with precursor cervical cancer lesions. Nutr Cancer 30: 46-52.

    Google Scholar 

  14. Vernon SD, Unger ER, Williams D (2000) Comparison of human papillomavirus detection and typing by cycle sequencing, line blotting, and hybrid capture. J Clin Microbiol 38: 651-655.

    Google Scholar 

  15. Giuliano AR, Harris RB, Sedjo RL, et al. (2002) Incidence, prevalence, and clearance of type-specific HPV infections: the young women's health study. J Infect Dis 186: 462-469.

    Google Scholar 

  16. Gravitt PE, Peyton CL, Alessi TQ, et al. (2000) Improved amplification of genital human papillomaviruses. J Clin Microbiol 38: 357-361.

    Google Scholar 

  17. Gravitt PE, Peyton CL, Apple RJ, Wheeler CM (1998) Genotyping of 27 human papillomavirus types by using l1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol 36: 3020-3027.

    Google Scholar 

  18. Craft NE (1996) High resolution HPLC method for the simultaneous analysis of carotenoids, retinoids, and tocopherols. FASAB J A527 ( Abstr #3039).

  19. The Food and Nutrition Board(2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington DC: National Academy Press, pp. 444-445, 448-457.

    Google Scholar 

  20. The Food and Nutrition Board(1998) Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press, pp. 512-513, 516-517.

    Google Scholar 

  21. Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE, Comstock GW (1993) Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol Biomarkers Prev 2: 335-339.

    Google Scholar 

  22. Potischman N, Herrero R, Brinton LA, et al. (1991) A case-control study of nutrient status and invasive cervical cancer. II. Serologic indicators. Am J Epidemiol 134: 1347-1355.

    Google Scholar 

  23. Goodman MT, Kiviat N, McDuffie K, et al. (1998) The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. Cancer Epidemiol Biomarkers Prev 7: 537-544.

    Google Scholar 

  24. Kanetsky PA, Gammon MD, Mandelblatt J, et al. (1998) Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, Black women. Nutr Cancer 31: 31-40.

    Google Scholar 

  25. Arab L, Steck-Scott S, Bowen P (2002) Participation of lycopene and beta-carotene in carcinogenesis: defenders, aggressors, or passive bystanders? Epidemiol Rev 23: 211-230.

    Google Scholar 

  26. Clinton SK (1998) Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev 56: 35-51.

    Google Scholar 

  27. Di Mascio P, Murphy ME, Sies H (1991) Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols. Am J Clin Nutr 53: 194S-200S.

    Google Scholar 

  28. Palmer HJ, Paulson KE (1997) Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutr Rev 55: 353-361.

    Google Scholar 

  29. Rosl F, Schwarz E (1997) Regulation of E6 and E7 oncogenic transcription. In: Tommasino M, ed. Papillomaviruses in Human Cancer: Role of E6 and E7 Oncoproteins, Austin, Texas: Landes Bioscience and Chapmena &; Hall, pp. 25-70.

    Google Scholar 

  30. Rosl F, Das BC, Lengert M, Geletneky K, zur Hausen H (1997) Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription. J Virol 71: 362-370.

    Google Scholar 

  31. Moscicki AB, Shiboski S, Broering J, et al. (1998) The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatr 132: 277-284.

    Google Scholar 

  32. Cooney RV, Franke AA, Hankin JH, et al. (1995) Seasonal variations in plasma micronutrients and antioxidants. Cancer Epidemiol Biomarkers Prev 4: 207-215.

    Google Scholar 

  33. Peng YM, Peng YS, Childers JM, et al. (1998) Concentrations of carotenoids, tocopherols, and retinol in paired plasma and cervical tissue of patients with cervical cancer, precancer, and noncancerous diseases. Cancer Epidemiol Biomarkers Prev 7: 347-350.

    Google Scholar 

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Authors and Affiliations

  1. Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA

    Rebecca L. Sedjo, Mary R. Papenfuss & Anna R. Giuliano

  2. Craft Technologies, Inc., Wilson, North Carolina, USA

    Neal E. Craft

  3. Arizona College of Public Health, University of Arizona, Tucson, Arizona, USA

    Anna R. Giuliano

Authors
  1. Rebecca L. Sedjo
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  2. Mary R. Papenfuss
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  3. Neal E. Craft
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  4. Anna R. Giuliano
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Correspondence to Anna R. Giuliano.

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Sedjo, R.L., Papenfuss, M.R., Craft, N.E. et al. Effect of plasma micronutrients on clearance of oncogenic human papillomavirus (HPV) infection (United States). Cancer Causes Control 14, 319–326 (2003). https://doi.org/10.1023/A:1023981505268

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