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Is a Mild Deficit in Executive Functions in Boys Related to Childhood ADHD or to Parental Multigenerational Alcoholism?

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Abstract

A mild deficit in executive functions has been hypothesized to be associated with attention deficit hyperactivity disorder (ADHD), with externalizing problem behaviors such as conduct disorder (CD) and with the vulnerability to alcoholism in sons of multi-generational alcoholics (SOMGAs). These three categories overlap, which raises concerns about the specificity of the hypothesized associations. In the present study, measures of executive functions (EFs) were tested in seventy-six 7- to 11-year-old boys: boys with ADHD but without a family history of addiction, SOMGAs, and controls. Specific deficits in EFs were found for boys with ADHD but not for SOMGAs. The association between a deficit in EFs and attention problems remained after controlling for externalizing problem behaviors, but not for the reverse. These results suggest that a mild deficit in EFs is specifically related to ADHD and that the deficits reported in boys with CD and in SOMGAs are due to relatively high attentional problems in these groups or due to other factors such as motivation.

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REFERENCES

  • Achenbach, T. M. (1991). Integrative guide for the 1991 CBCL/4-18 YSR, and TRF profiles. Burlington: University of Vermont Department of Psychiatry.

    Google Scholar 

  • American Psychiatric Association. (1987). Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.). Washington, DC: Author.

    Google Scholar 

  • American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, D.C.: Author.

    Google Scholar 

  • Babor, T. F., Hofmann, M., DelBoca, F. K., Hesselbrock, V., Meyer, R. E., Dolinsky, Z. D., & Rounsaville, B. (1992). Types of alcoholics, I. Evidence for an emperically derived typology based on indications of vulnerability and severity. Archives of General Psychiatry, 49, 599–608.

    Google Scholar 

  • Baker, S. C., Rogers, R. D., Owen, A. M., Frith, C. D., Dolan, R. J., Frackowiak, R. S. J., & Robbins, T. W. (1996). Neural systems engaged by planning: A PET study of the Tower of London task. Neuropsychologia, 34, 515–526.

    Google Scholar 

  • Barkley, R. A. (1997). Behavioral inhibition, susained attention, and executive funtions: constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65–94.

    Google Scholar 

  • Barkley, R. A., Grodzinsky, G., & DuPaul, G. (1992). Frontal lobe functions in attention deficit disorder with and without hyperactivity: A review and research report. Journal of Abnormal Child Psychology, 20, 163–188.

    Google Scholar 

  • Bates, M. E., & Pandina, R. J. (1992). Familial alcoholism and premorbid cognitive deficit: A failure to replicate subtype differences. Journal of Studies on Alcohol, 53, 320–327.

    Google Scholar 

  • Biederman, J., Wilens, T., Mick, E., Faraone, S., Weber, W., Curtis, S., Thornell, A., Pfister, K., Garcia Jetton, J., & Soriano, J. (1997). Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study. Journal of the American Acedemy of Child and Adolescent Psychiatry, 36, 21–29.

    Google Scholar 

  • Clarren, S. K., Sampson, P. D., Larsen, J., Donnell, D. J., Barr, H. M., Bookstein, F. L., Martin, D. C., & Streissguth, A. P. (1987). Facial effects of fetal alcohol exposure: Assessment by photographs and morphometric analysis. American Journal Medical Genetics, 26, 651–666.

    Google Scholar 

  • Cloninger, C. R. (1987). Neurogenetic adaptive mechanisms in alcoholism. Science, 236, 410–416.

    Google Scholar 

  • Cooper, L., Russell, M., & George, W. (1988). Coping, expectancies, and alcohol abuse: A test of social learning formulations. Journal of Abnormal Psychology, 97, 218–230.

    Google Scholar 

  • Damasio, A. R. (1994). Descartes' error. Emotion, reason, and the human brain. New York: Avon.

    Google Scholar 

  • Daugherty, T. K., & Quay, H. C. (1991). Response perseveration and delayed responding in childhood behavior disorders. Journal Child Psychology and Psychiatry, 32, 453–461.

    Google Scholar 

  • Dobkin, P. L., Tremblay, R. E. & Sacchitelle, C. (1997). Predicting boys' early-onset substance abuse from father's alcoholism, son's disruptiveness, and mother's parenting behavior. Journal of Consulting and Clinical Psychology, 65, 86–92.

    Google Scholar 

  • Eslinger, P. J. (1996). Conceptualizing, describing, and measuring components of executive function, a summary. In G. R. Lyon & N. A. Krasnegor (Eds.), Attention, memory and executive function (pp. 367–396). London: Paul H. Brookes.

    Google Scholar 

  • Fergusson, D. M., & Horwood, L. J. (1995). Early disruptive behavior, IQ, and later school achievement and delinquent behavior. Journal of Abnormal Child Psychology, 23, 183–199.

    Google Scholar 

  • Fergusson, D. M., Lynskey, M. T., & Horwood, L. J. (1997). Attentional difficulties in middle childhood and psychosocial outcomes in young adulthood. Journal of Child Psychology and Psychiatry, 38, 633–644.

    Google Scholar 

  • Finn, P. R., Kessler, D. N., & Hussong, A. M. (1994). Risk for alcoholism and classical conditioning to signals for punishment: Evidence for a weak behavioral inhibition system? Journal of Abnormal Psychology, 103, 293–301.

    Google Scholar 

  • Fuster, J. M. (1989). The prefrontal cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe. (2nd. Ed.), New York: Raven Press.

    Google Scholar 

  • Giancola, P. R., Peterson, J., & Pihl, R. O. (1993). Risk for alcoholism, antisocial behavior, and response perseveration. Journal of Clinical Psychology, 49, 423–428.

    Google Scholar 

  • Giancola, P. R., & Zeichner, A. (1994). Neuropsychological performance on tests of frontal-lobe funcioning and aggressive behavior in men. Journal of Abnormal Psychology, 103, 832–835.

    Google Scholar 

  • Gorenstein, E. E. (1987). Cognitive-perceptual deficit in an alcoholism spectrum disorder. Journal of Studies on Alcohol, 48, 310–318.

    Google Scholar 

  • Gorenstein, E. E., & Newman, J. P. (1980). Disinhibitory psychopathology: A new perspective and a model for research. Psychological Review, 87, 301–315.

    Google Scholar 

  • Grafman, J. (1989). Plans, actions and mental sets: Managerial knowledge units in the frontal lobes. In E. Perecman (Ed.), Integrating theory and practice in clinical neuropsychology (pp. 93–138). Hillsdale, NJ: Erlbaum.

    Google Scholar 

  • Gray, J. A. (1982). The neuropsychology of anxiety: An enquiry into the function of the septo-hippocampal system. New York: Oxford University Press.

    Google Scholar 

  • Groth-Marnat, G. (1990). Handbook of psychological assessment. 2nd Ed. NY: Wiley.

    Google Scholar 

  • Gunning, W. B., Pattiselanno, W. E. Van der Stelt, O., & Wiers, R. W. (1994). Children of alcoholics: Predictors for psychopathology and addiction. Acta Pediatrica Supplement, 404, 7–8.

    Google Scholar 

  • Harden, P. W., & Pihl, R. O. (1995). Cognitive function, cardiovascular reactivity, and behavior in boys at high risk for alcoholism. Journal of Abnormal Psychology, 104, 94–103.

    Google Scholar 

  • Hare, R. D. (1993). Without conscience: The disturbing world of the psychopaths among us. New York: Pocket Books.

    Google Scholar 

  • Hinshaw, S. P. (1987). On the distinction between attentional deficits/hyperactivity and conduct problems/aggression in child psychopathology. Psychological Bulletin, 101, 443–463.

    Google Scholar 

  • Hill, S. Y., & Smith, T. R. (1991). Evidence for genetic mediation of alcoholism in women. Journal of Substance Abuse, 3, 159–174.

    Google Scholar 

  • Huberty, C. J., & Morris, J. D. (1989). Multivariate analysis versus multiple univariate analysis. Psychological Bulletin, 105, 302–308.

    Google Scholar 

  • Huberty, C. J., & Smith, J. D. (1982). The study of effect in MANOVA. Multivariate Behavioral Research, 17, 417–432.

    Google Scholar 

  • Hughes, C., Russell, J., & Robbins, T. W. (1992). Evidence for executive dysfunction in autism. Neuropsychologia, 32, 477–492.

    Google Scholar 

  • Iaboni, F., Douglas, V. I., & Baker, A. G. (1995). Effects of reward and response cost on inhibition in ADHD children. Journal of Abnormal Psychology, 104, 232–240.

    Google Scholar 

  • Iaboni, F., Douglas, V. I., & Ditto, B. (1997). Psychophysiological response of ADHD children to reward and extinction. Psychophysiology, 34, 116–123.

    Google Scholar 

  • Iversen, S. D., & Dunnett, S. B. (1990). Functional organization of striatum as studied with neural graphs. Neuropsychologia, 28, 601–626.

    Google Scholar 

  • Kagan, J., Rosman, B. L., Day, D., Albert, J., & Phillips, W. (1964). Information processing in the child, significance of analytic and reflective attitudes. Psychological Monographs (1, Whole No. 578).

  • Kasius, M. (1997). Interviewing children: Development of the Dutch version of the semistructured Clinical Interview for Children and Adolescents (SCICA) and testing the psychometric properties. Unpublished doctoral dissertation, Erasmus Universiteit, Rotterdam, The Netherlands.

  • Kendler, K. S., Neale, M. C., Heath, A. C., Phil, R. O., Kessler, R. C., & Eaves, L. J. (1994). A twin study on alcoholism in women. American Journal of Psychiatry, 151, 707–715.

    Google Scholar 

  • Kokkevi, A., & Hartgers, C. (1995). EuropASI: European adapatation of a multidimensional assessment instrument for drug and alcohol dependence. European Addiction Research, 1, 208–210.

    Google Scholar 

  • Krikorian, R., Bartok, J., & Gay, N. (1994). Tower of London procedure: A standard method and developmental data. Journal of Clinical and Experimental Neuropsychology, 16, 840–850.

    Google Scholar 

  • Lilienfield, S. O., & Waldman, I. D. (1990). The relation between childhood attention-deficit hyperactivity disorder and adult antisocial behavior re-examined: The problem of heterogeneity. Clinical Psychology Review, 10, 699–725.

    Google Scholar 

  • Lynam, D. R. (1996). Early identification of chronic offenders: Who is the fledgling psychopath? Psychological Bulletin, 120, 209–234.

    Google Scholar 

  • Martin, C. S., Earleywine, M., Blackson, T. C., Vanyukov, M. M., Moss, H. B., & Tarter, R. E. (1994). Aggressivity, Inattention, hyperactivity, and impulsivity in boys at high and low risk for substance abuse. Journal of Abnormal Child Psychology, 22, 177–203.

    Google Scholar 

  • McCord, J. (in press). “He did it because he wanted to....” In W. Osgood (Ed.), Nebraska Symposium on Motivation (pp. 1–43). Lincoln: University of Nebraska Press.

  • McGue, M. (1993). From proteins to cognitions: The behavioral genetics of alcholism. In R. Plomin & G. E. McClearn (Eds.), Nature, Nurture and Psychology (pp. 245–268). Washington DC: American Psychological Association.

    Google Scholar 

  • McGue, M., Pickens, R. W., & Svikis, D. S. (1992). Sex and age effects on the inheritance of alcohol problems: A twin study. Journal of Abnormal Psychology, 101, 3–17.

    Google Scholar 

  • Meehl, P. E. (1970). Nuisance variables and the ex post facto design. In M. Radner & S. Winoku (Eds.), Minnesota studies in the philosophy of science (pp. 373–402). Minneapolis: University of Minnesota Press.

    Google Scholar 

  • Moffit, T. E. (1993). The neuropsychology of conduct disorder. Development and Psychopathology, 5, 135–151.

    Google Scholar 

  • Myers, J. L., & Well, A. D. (1991). Research design and statistical analysis. New York: HarperCollins.

    Google Scholar 

  • Newlin, D. B., & Thomson, J. B. (1990). Alcohol challenge with sons of alcoholics: A critical review and analysis. Psychological Bulletin, 108, 383–402.

    Google Scholar 

  • Newman, J. P., Patterson, C. M., & Kosson, D. S. (1987). Response perseveration in psychopaths. Journal of Abnormal Psychology, 96, 145–148.

    Google Scholar 

  • Newman, J. P., & Wallace J. F. (1993). Diverse pathways to deficient self-regulation: Implications for disinhibitory psychopathology in children. Clinical Psychology Review, 13, 699–720.

    Google Scholar 

  • Oosterlaan, J., Logan, G. D., & Sergeant, J. A. (1998). Response inhibition in ADHD, CD, comorbid ADHD + CD, anxious, and normal children: A meta-analysis of studies with the stop task. Journal of Child Psychology and Psychiatry, 39, 411–425.

    Google Scholar 

  • Oosterlaan, J., & Sergeant, J. A. (1998). Response inhibition and the effects of reward and response cost: A comparison between ADHD, disruptive, anxious and normal children. Journal of Abnormal Child Psychology.

  • Ozkaragoz, T. Z., & Noble, E. P. (1995). Neuropsychological differences between sons of active alcoholic and non-alcoholic fathers. Alcohol and Alcoholism, 30, 115–123.

    Google Scholar 

  • Ozkaragoz, T. Z., Satz, P., & Noble, E. P. (1997). Neuropsychological functioning in sons of active alcoholic, recovering alcoholic, and social drinking fathers. Alcohol, 14, 31–37.

    Google Scholar 

  • Patterson, C. M., & Newman, J. P. (1993). Reflectivity and learning from aversive events: Toward a psychological mechanism for syndromes of disinhibition. Psychological Review, 100, 716–736.

    Google Scholar 

  • Pennington, B. F. (1994). The working memory function of the prefrontal cortices: Implications for developmental and individual differences in cognition. In M. M. Haith, J. Benson, R. Roberts, & B. F. Pennington (Eds.), The development of future oriented processes (pp. 243–289). Chicago: University of Chicago Press.

    Google Scholar 

  • Pennington, B. F., & Ozonoff, S. (1996). Executive funtions and developmental psychopathology. Journal of Child Psychology and Psychiatry, 37, 51–87.

    Google Scholar 

  • Peterson, J., Finn, P., & Pihl, R. (1992). Cognitive dysfunction and the inherited predisposition to alcoholism. Journal of Studies on Alcohol, 53, 154–160.

    Google Scholar 

  • Petrides, M., Aliviasatos, B., Evans, A. C., & Meyer, E. (1993). Dissociation of human mid-dorsolateral from posterio dorsolateral frontal cortex in memory processing. Proceedings of the National Academy of Sciences, 90, 873–877.

    Google Scholar 

  • Petrides, M., Aliviasatos, B., Meyer, E., & Evans, A. C. (1993). Functional activation of the human frontal cortex during performance of verbal working memory tasks. Proceedings of the National Academy of Sciences, 90, 878–882.

    Google Scholar 

  • Petrides, M., & Milner, B. (1982). Deficits on subject-ordered tasks after frontal-and temporal-lobe lesions in man. Neuropsychologia, 20, 249–262.

    Google Scholar 

  • Pihl, R. O., & Bruce, K. R. (1995). Cognitive impairments in children of alcoholics. Alcohol Health and Research World, 19, 142–147.

    Google Scholar 

  • Pihl, R. O., Peterson, J., & Finn, P. (1990a). An heuristic model for the inherited predispostion to alcoholism. Psychology of Addictive Behaviors, 4, 12–25.

    Google Scholar 

  • Pihl, R. O., Peterson, J., & Finn, P. (1990b). Inherited predisposition to alcoholism: Characteristics of sons of male alcoholics. Journal of Abnormal Psychology, 99, 291–301.

    Google Scholar 

  • Quay, H. C. (1988). Attention-deficit disorder and the behavioral inhibition system: The relevance of the neuropsychological theory of Jeffrey Gray. In L. M. Bloomingdale & J. A. Sergeant (Eds.), Attention deficit disorder: Criteria, cognition, intervention. (pp. 117–125). Oxford, England: Pergamon Press.

    Google Scholar 

  • Quay, H. C. (1993). The psychobiology of undersocialized aggressive conduct disorder: A theoretical perspective. Development and Psychopathology, 5, 165–180.

    Google Scholar 

  • Robins, L. N., Wing, J. K., Wittschen, H. U., Helzer, J. E., Babor, T. F., Burke, J., Farmer, A., Jablenski, A., Pickens, R., Regier, D. A. Sartorius, N., & Towle, L. H. (1988). The Composite International Diagnostic Interview: An epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of General Psychiatry, 38, 1069–1077.

    Google Scholar 

  • Sattler, J. M. (1992). Assessment of children. (3rd ed., rev. and updated). San Diego: J. M. Sattler.

    Google Scholar 

  • Schaffer, D. (1992). Diagnostic Interview Schedule for Children (DISC 2.3) Parent Version. New York: Columbia University Press. (Translation into Dutch by F. C. Verhulstand M.Kasius)

    Google Scholar 

  • Schuckit, M. A., & Smith, T. L. (1996). An 8-year follow-up of 450 sons of alcoholic and control subjects. Archives General Psychiatry, 53, 202–210.

    Google Scholar 

  • Sergeant, J. A., Oosterlaan, J., & Van der Meere, J. (1999). Information processing and energetic factors in attention-deficit hyperactivity disorder. In H. C. Quay & A. E. Hogan (Eds.), Handbook of disruptive behaviors (pp. 95–104). New York: Plenum Press.

    Google Scholar 

  • Shallice, T. (1982). Specific impairments of planning. Philosophical Transactions of the Royal Society of London, 298, 199–209.

    Google Scholar 

  • Sher, K. J. (1991). Children of alcoholics: A critical appraisal of theory and research. Chicago: University of Chicago Press.

    Google Scholar 

  • Sher, K. J., Walitzer, K. S., Wood, P. K., & Brent, E. E. (1991). Characteristics of children of alcoholics: Putative risk factors, substance use and abuse and psychopathology. Journal of Abnormal Psychology, 100, 427–448.

    Google Scholar 

  • Shue, K. L., & Douglas, V. I. (1992). Attention deficit hyperactivity disorder and the frontal lobe syndrome. Brain and Cognition, 20, 104–124.

    Google Scholar 

  • Smith, G. T., Goldman, M. S., Greenbaum, P. E., & Christiansen, B. A. (1995). Expectancy for social facilitation from drinking: The divergent paths of high-expectancy and low-expectancy adolescents. Journal of Abnormal Psychology, 104, 32–40.

    Google Scholar 

  • Stuss, D. T. (1992). Biological and psychological development of executive functions. Brain and Cognition, 20, 8–23.

    Google Scholar 

  • Stuss, D. T., & Benson, D. F. (1984). Neuropsychological functions of the frontal lobes. Psychological Bulletin, 95, 3–28.

    Google Scholar 

  • Tarter, R. E., Alterman, A. I., & Edwards, K. L. (1985). Vulnerability to alcoholism in men: A behavior genetic perspective. Journal of Studies on Alcohol, 46, 329–356.

    Google Scholar 

  • Tarter, R. E., Jacob, T., & Bremer, D. A. (1989a). Cognitive status of sons of alcoholic men. Alcoholism: Clinical and Experimental Research, 13, 232–235.

    Google Scholar 

  • Tarter, R. E., Jacob, T., & Bremer, D. A. (1989b). Specific cognitive impairments in sons of early onset alcoholics. Alcoholism: Clinical and Experimental Research, 13, 786–789.

    Google Scholar 

  • Van Haasen, P. P., De Bruyn, E. E. J., Pijl, Y. J., Poortinga, Y. H. Lutje Spelberg, H. C., Vander Steene, G., Coetsier, P., Spoelders-Claes, R., & Stinissen, J. (1986). Wechsler Intelligence Scale for Children — Revised. Nederlandstalige Uitgave [Dutch Edition]. Lisse, The Netherlands: Swets & Zeitlinger.

    Google Scholar 

  • Van Westerlaak, J. M., Kropman, J. A., & Collaris, J. W. M. (1975). Beroepenklapper. Nijmegen, The Netherlands: Instituut voor Toegepaste Sociologie.

    Google Scholar 

  • Verhulst, F. C., Koot, J. M., Akkerhuis, G. W., & Veerman, J. W. (1990). Practische Handleiding voor de CBCL (Child Behavior Checklist) [Manual for the CBCL]. Assen, The Netherlands: Van Gorcum.

    Google Scholar 

  • Verhulst, F. C., Van der Ende, J., & Koot, H. M. (1996). Handleiding voor de CBCL/4-18. Rotterdam: Afd. Kinder-en Jeugdpsychiatrie Sophia Kinderziekenhuis, The Netherlands.

    Google Scholar 

  • West, M. O., & Prinz, R. J. (1987). Parental alcoholism and childhood psychopathology. Psychological Bulletin, 102, 204–218.

    Google Scholar 

  • Whipple, S. C., Parker, E. S., & Noble, E. P. (1988). An atypical neurocognitive profile in alcoholic fathers and their sons. Journal of Studies on Alcohol, 49, 240–244.

    Google Scholar 

  • White, J. L., Moffit, T. E., Caspi, A., Bartusch, D. J., Needless, D. J., & Stouthamer-Loeber, M. (1994). Measuring impulsivity and examining its relationship to delinquency. Journal of Abnormal Psychology, 103, 192–205.

    Google Scholar 

  • Wickelgren, I. (1997). Getting the brain's attention. Science, 278, 35–37.

    Google Scholar 

  • Wiegersma, S., Van der Scheer, E., & Hijman, R. (1990). Subjective ordering, short-term memory, and the frontal lobes. Neuropsychologia, 28, 95–98.

    Google Scholar 

  • Wiers, R. W., Hoogeveen, K. J., Sergeant, J. A., & Gunning, W. B. (1997). High and low dose expectancies and the differential associations with drinking in male and female adolescents and young adults. Addition, 92, 871–888.

    Google Scholar 

  • Wiers, R. W., Sergeant, J. A. & Gunning, W. B. (1994). Psychological mechanisms of enhanced risk of addiction: A dual pathway? Acta Pediatrica Supplement, 404, 9–13.

    Google Scholar 

  • Workman-Daniels, K. L., & Hesselbrock, V. M. (1987). Childhood problem behavior and neuropsychological functioning in persons at risk for alcoholism. Journal of Studies on Alcohol, 48, 187–193.

    Google Scholar 

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Authors and Affiliations

  1. Academic Medical Center, University of Amsterdam, Amsterdam, 1018 WB, The Netherlands

    Reinout W. Wiers

  2. Maastricht University, 6200 MD, Maastricht, The Netherlands

    Reinout W. Wiers

  3. Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands

    Reinout W. Wiers & W. Boudewijn Gunning

  4. Clinical Psychology, University of Amsterdam, 1018 WB, Amsterdam, The Netherlands

    Reinout W. Wiers & Joseph A. Sergeant

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Wiers, R.W., Gunning, W.B. & Sergeant, J.A. Is a Mild Deficit in Executive Functions in Boys Related to Childhood ADHD or to Parental Multigenerational Alcoholism?. J Abnorm Child Psychol 26, 415–430 (1998). https://doi.org/10.1023/A:1022643617017

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