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Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration

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Abstract

These experiments evaluate overexpression of basic fibroblast growth factor (FGF-2) as a treatment to decrease photoreceptor cell death in the constant light damage model of retinal degeneration. Increased FGF-2 expression was accomplished by gene transfer to the retina via injection into the subretinal space of a recombinant adeno-associated virus (rAAV), containing the FGF-2 gene. Rescue effects were assessed by morphometry and electroretinographic analysis.

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Authors and Affiliations

  1. School of Optometry and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA

    Dana Lau & John Flannery

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  1. Dana Lau
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  2. John Flannery
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Lau, D., Flannery, J. Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration. Doc Ophthalmol 106, 89–98 (2003). https://doi.org/10.1023/A:1022481306146

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  • DOI: https://doi.org/10.1023/A:1022481306146

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