Abstract
2-Pyridylaminomethyleneisopropylidenemalonates, prepared from ethoxymethyleneisopropylidenemalonate and 2-aminopyridines, form 4-oxo-4H-pyrido[1,2-a]pyrimidines at their melting points and are separated from the reaction mixture by sublimation.
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REFERENCES
D. R. Zicane, Z. F. Tetere, I. A. Rijkure, M. V. Petrova, E. Yu. Gudriniece, and U. O. Kalejs, Khim. Geterotsikl. Soedin., 903 (2000).
H. Akimoto, T. Miwa, and K. Otsu, Jap. Pat. 04,235,986; Chem. Abstr., 118, 213101 (1993).
B. Hurlbert and B. Valenti, J. Med. Chem., 11, 708 (1968).
H. Parish, P. Gilliom, W. Purcell, R. Browne, R. Spirk, and H. White, J. Med. Chem., 25, 98 (1982).
D. Bouzard, Anitbiotics and Antiviral Compounds, VCH (Weinheim), 186 (1993).
D. R. Zicane, I. T. Ravina, Z. F. Tetere, I. A. Rijkure, E. J. Gudrinece, and U. O. Kalejs, Khim. Geterotsikl. Soedin., 857 (2000).
J. Quiroga, A. Hormoza, B. Insuasty, C. Saitz, C. Jullian, and A. Canete, J. Heterocycl. Chem., 35, 61 (1998).
G. Bihlmayer, G. Derflinger, J. Derkosch, and O. Polansky, Monatsh. Chem., 98, 564 (1967).
Sterling Drug, Brit. Pat. 1147759; Chem. Abstr., 71, 70125 (1969).
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Ravina, I., Zicane, D., Petrova, M. et al. Exotic Amino Acids. 6. Synthesis of Substituted 4-Oxo-4H-pyrido[1,2-a]pyrimidines. Chemistry of Heterocyclic Compounds 38, 836–839 (2002). https://doi.org/10.1023/A:1020689805869
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DOI: https://doi.org/10.1023/A:1020689805869