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The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures

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Abstract

A 10 mm gap in a rat sciatic nerve was bridged by a bioartificial nerve graft consisting of a silicone tube containing seven longitudinally placed filaments made of non-resorbable material (polyamide [Ethilon®]) or resorbable materials (polydioxanon [PDS®], polyglactin [Vicryl®] or catgut). The purpose was to study the tissue reaction induced by the four different types of materials. At 4 weeks an immunocytochemical technique, using ED1 and ED2 monoclonal antibodies, was used to study the presence and location of macrophages. A large number of macrophages were found accumulating on the surface of catgut and polyglactin, while few were found on the surface of polyamide and polydioxanon filaments. It is concluded that the cell layers on the filament surface mainly consisted of ED1 positive cells and their thickness depends on the filament materials.

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References

  1. N. DANIELSEN, Restor. Neurol. Neurosci. 1 (1990) 253.

    Google Scholar 

  2. F. LANGONE, S. LORA, F. M. VERONESE, P. CALICETI, P. P. PARNIGOTTO, F. VALENTI and G. PALMA, Biomaterials 16 (1995) 347

    Google Scholar 

  3. F. M. LONGO, M. MANTHORPE and S. VARON, Brain Res. 255 (1982) 277.

    Google Scholar 

  4. G. LUNDBORG and H. A. HANSSON, J. Hand Surg. 5A (1980) 35.

    Google Scholar 

  5. G. LUNDBORG, B. ROSEN, S. O. ABRAHAMSSON, L. B. DAHLIN and N. DANIELSEN, ibid. 19B (1994) 273.

    Google Scholar 

  6. S. E. MACKINNON and A. L. DELLON, Plast. Reconstr. Surg. 85 (1990) 419.

    Google Scholar 

  7. R. D. MADISON, C. F. DASILVA, P. DIKKES, T. H. CHUI and R. L. SIDMAN, Exp. Neurol. 88 (1985) 767.

    Google Scholar 

  8. R. D. MADISON, C. F. DASILVA, P. DIKKES, R. L. SIDMAN and T. H. CHUI, ibid. 95 (1987) 378.

    Google Scholar 

  9. L. R. WILLIAMS and S. VARON, J. Comp. Neurol. 231 (1985) 209.

    Google Scholar 

  10. Q. ZHAO, L. B. DAHLIN, M. KANJE and G. LUNDBORG, Restor. Neurol. Neurosci. 5 (1993) 197.

    Google Scholar 

  11. G. LUNDBORG and M. S. KANJE, Scand. J. Plast. Reconstr. Hand Surg. 30 (1995) 105.

    Google Scholar 

  12. N. TERADA, L. M. BJURSTEN, D. DOHI and G. LUNDBORG, ibid. in press.

  13. L. B. DAHLIN, ibid. 26 (1992) 121.

    Google Scholar 

  14. L. M. BJURSTEN and N. DANIELSEN, J. Biomed. Mater. Res. (1996) in press

  15. L. B. DAHLIN, Q. ZHAO and L. M. BJURSTEN, Restor. Neurol. Neurosci. 8 (1995) 199.

    Google Scholar 

  16. C. D. DIJKSTRA, E. A. DÖPP, P. JOLING and G. KRAAL, Immunology 54 (1985) 589.

    Google Scholar 

  17. S. MONACO, J. GEHRMANN, G. RAIVICH and G. W. KREUTZBERG, J. Neurocytol. 21 (1992) 623.

    Google Scholar 

  18. G. HEUFF, M. B. ENDE, H. BOUTKAN, W. PREVOO, L. G. BAYON, G. J. FLEUREN, R. H. BEELEN, S. MEIJER and C. D. DIJKSTRA, Scand. J. Immunol. 38 (1993) 10.

    Google Scholar 

  19. J. BIEWENGA, M. B. ENDE, L. F. KRIST, A. BORST, M. GHUFRON and N. ROOIJEN, Cell Tissue Res. 280 (1995) 189.

    Google Scholar 

  20. K. J. KOOL, M. Y. G. BOEYE, A. J. SEVERIJNEN and M. P. HAZENBERG, Scand. J. Immunol. 36 (1992) 497.

    Google Scholar 

  21. I. S. MCLENNAN, Cell Tissue Res. 272 (1993) 193.

    Google Scholar 

  22. B. A. S. PIERRE and J. G. TIDBALL, J. Appl. Physiol. 77 (1994) 290.

    Google Scholar 

  23. L. B. DAHLIN, Brain Res. 679 (1995) 274.

    Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinanomachi 35, Shinjuku Tokyo, 160, Japan

    N TERADA

  2. Department of Experimental Research, Malmo, Sweden

    L. M BJURSTEN

  3. Department of Hand Surgery, Malmo University Hospital, Lund University, S-205 02, Malmo, Sweden

    G LUNDBORG

Authors
  1. N TERADA
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  2. L. M BJURSTEN
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  3. G LUNDBORG
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TERADA , N., BJURSTEN , L.M. & LUNDBORG , G. The role of macrophages in bioartificial nerve grafts based on resorbable guiding filament structures. Journal of Materials Science: Materials in Medicine 8, 391–394 (1997). https://doi.org/10.1023/A:1018593219113

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  • DOI: https://doi.org/10.1023/A:1018593219113

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