Skip to main content
Log in

Selectin-carbohydrate interactions during inflammation and metastasis

  • Published:
Glycoconjugate Journal Aims and scope Submit manuscript

Abstract

L-, E-, and P-selectin are membrane-anchored, C-type lectins that initiate tethering and rolling of flowing leukocytes on endothelial cells, platelets, or other leukocytes during inflammation. The selectins bind to sialylated, fucosylated, or, in some cases, sulfated glycans on glycoproteins, glycolipids, or proteoglycans. However, they bind with relatively high affinity or avidity to only a few, appropriately modified glycoproteins on leukocytes or endothelial cells. One leukocyte mucin, PSGL-1, tethers flowing leukocytes to P-selectin on activated platelets or endothelial cells, and also helps tether leukocytes to L-selectin on other leukocytes. The physiologic expression of the selectins is tightly controlled to limit the inflammatory response. But dysregulated expression of the selectins may contribute to inflammatory and thrombotic disorders, and perhaps to tumor metastases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Springer TA (1995) Annu Rev Physiol 57: 827–72.

    PubMed  CAS  Google Scholar 

  2. Butcher EC, Picker LJ (1996) Science 272: 60–66.

    PubMed  CAS  Google Scholar 

  3. McEver RP, Moore KL, Cummings RD (1995) J Biol Chem 270: 11025–28.

    PubMed  CAS  Google Scholar 

  4. Tedder TF, Steeber DA, Chen A, Engel P (1995) FASEB J 9: 866–73.

    PubMed  CAS  Google Scholar 

  5. Kansas GS (1996) Blood 88: 3259–87.

    PubMed  CAS  Google Scholar 

  6. Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang K-S, Presky DH, Familletti PC, Wolitzky BA, Burns DK (1994) Nature 367: 532–38.

    PubMed  CAS  Google Scholar 

  7. Erbe DV, Watson SW, Presta LG, Wolitzky BA, Foxall C, Brandley BK, Lasky LA (1993) J Cell Biol 120: 1227–35.

    PubMed  CAS  Google Scholar 

  8. Erbe DV, Wolitzky BA, Presta LG, Norton CR, Ramos RJ, Burns DK, Rumberger JM, Rao BNN, Foxall C, Brandley BK, Lasky LA (1992) J Cell Biol 119: 215–27.

    PubMed  CAS  Google Scholar 

  9. Hollenbaugh D, Bajorath J, Stenkamp R, Aruffo A (1993) Biochemistry 32: 2960–66.

    PubMed  CAS  Google Scholar 

  10. Bajorath J, Hollenbaugh D, King G, Harte W, Jr., Eustice DC, Darveau RP, Aruffo A (1994) Biochemistry 33: 1332–39.

    PubMed  CAS  Google Scholar 

  11. Revelle BM, Scott D, Kogan TP, Zheng JH, Beck PJ (1996) J Biol Chem 271: 4289–97.

    PubMed  CAS  Google Scholar 

  12. Kansas GS, Saunders KB, Ley K, Kakrzewicz A, Gibson RM, Furie BC, Furie B, Tedder TF (1994) J Cell Biol 124: 609–18.

    PubMed  CAS  Google Scholar 

  13. Gibson RM, Kansas GS, Tedder TF, Furie B, Furie BC (1995) Blood 85: 151–58.

    PubMed  CAS  Google Scholar 

  14. Tu LL, Chen AJ, Delahunty MD, Moore KL, Watson SR, McEver RP, Tedder TF (1996) J Immunol 157: 3995–4004.

    PubMed  CAS  Google Scholar 

  15. Revelle BM, Scott D, Beck PJ (1996) J Biol Chem 271: 16160–70.

    PubMed  CAS  Google Scholar 

  16. Kolbinger F, Patton JT, Geisenhoff G, Aenis A, Li XH, Katopodis AG (1996) Biochemistry 35: 6385–92.

    PubMed  CAS  Google Scholar 

  17. Ushiyama S, Laue TM, Moore KL, Erickson HP, McEver RP (1993) J Biol Chem 268: 15229–37.

    PubMed  CAS  Google Scholar 

  18. Varki A (1994) Proc Natl Acad Sci USA 91: 7390–97.

    PubMed  CAS  Google Scholar 

  19. Crocker PR, Feizi (1996) Curr Opin Struct Biol 6: 679–91.

    PubMed  CAS  Google Scholar 

  20. Moore KL, Stults NL, Diaz S, Smith DL, Cummings RD, Varki A, McEver RP (1992) J Cell Biol 118: 445–56.

    PubMed  CAS  Google Scholar 

  21. Levinovitz A, Muühlhoff J, Isenmann S, Vestweber D (1993) J Cell Biol 121: 449–59.

    PubMed  CAS  Google Scholar 

  22. Steegmaier M, Levinovitz A, Isenmann S, Borges E, Lenter M, Kocher HP, Kleuser B. Vestweber D (1995) Nature 373: 615–20.

    PubMed  CAS  Google Scholar 

  23. Sako D, Chang X-J, Barone KM, Vachino G, White HM, Shaw G, Veldman GM, Bean KM, Ahern TJ, Furie B, Cummings DA, Larsen GR (1993) Cell 75: 1179–86.

    PubMed  CAS  Google Scholar 

  24. Imai Y, Lasky LA, Rosen SD (1993) Nature 361: 555–57.

    PubMed  CAS  Google Scholar 

  25. Hemmerich S, Butcher EC, Rosen SD (1994) J Exp Med 180: 2219–26.

    PubMed  CAS  Google Scholar 

  26. Wilkins PP, Moore KL, McEver RP, Cummings RD (1995) J Biol Chem 270: 22677–80.

    PubMed  CAS  Google Scholar 

  27. Pouyani T, Seed B (1995) Cell 83: 333–43.

    PubMed  CAS  Google Scholar 

  28. Sako D, Comess KM, Barone KM, Camphausen RT, Cumming DA, Shaw GD (1995) Cell 83: 323–31.

    PubMed  CAS  Google Scholar 

  29. Li F, Wilkins PP, Crawley S, Weinstein J, Cummings RD, McEver RP (1996) J Biol Chem 271: 3255–64.

    PubMed  CAS  Google Scholar 

  30. Hemmerich S, Bertozzi CR, Le§er H, Rosen SD (1994) Biochemistry 33: 4820–29.

    PubMed  CAS  Google Scholar 

  31. Hemmerich S, Rosen SD (1994) Biochemistry 33: 4830–35.

    PubMed  CAS  Google Scholar 

  32. Hemmerich S, Le§er H, Rosen SD (1995) J Biol Chem 270: 12035–47.

    PubMed  CAS  Google Scholar 

  33. Wilkins PP, McEver RP, Cummings RD (1996) J Biol Chem 271: 18732–42.

    PubMed  CAS  Google Scholar 

  34. Crottet P, Kim YJ, Varki A (1996) Glycobiology 6: 191–208.

    PubMed  CAS  Google Scholar 

  35. Bargatze RF, Kurk S, Butcher EC, Jutila MA (1994) J Exp Med 180: 1785–92.

    PubMed  CAS  Google Scholar 

  36. Jutila MA, Kurk S (1996) J Immunol 156: 289–96.

    PubMed  CAS  Google Scholar 

  37. Simon SI, Rochon YP, Lynam EB, Smith CW, Anderson DC, Sklar LA (1993) Blood 82: 1097–106.

    PubMed  CAS  Google Scholar 

  38. Walcheck B, Moore KL, McEver RP, Kishimoto TK (1996) J Clin Invest 98: 1081–87.

    PubMed  CAS  Google Scholar 

  39. Fuhlbrigge RC, Alon R, Puri KD, Lowe JB, Springer TA (1996) J Cell Biol 135: 837–48.

    PubMed  CAS  Google Scholar 

  40. Alon R, Fuhlbrigge RC, Finger EB, Springer TA (1996) J Cell Biol 135: 849–65.

    PubMed  CAS  Google Scholar 

  41. Diacovo TG, Puri KD, Warnock RA, Springer TA, Von Andrian UH (1996) Science 273: 252–55.

    PubMed  CAS  Google Scholar 

  42. Alon R, Hammer DA, Springer TA (1995) Nature 374: 539–42.

    PubMed  CAS  Google Scholar 

  43. Finger EB, Puri KD, Alon R, Lawrence MB, Von Andrian UH, Springer TA (1996) Nature 379: 266–69.

    PubMed  CAS  Google Scholar 

  44. Walcheck B, Kahn J, Fisher JM, Wang BB, Fisk RS, Payan DG, Feehan C, Betageri R, Darlak K, Spatola AF, Kishimoto TK (1996) Nature 380: 720–23.

    PubMed  CAS  Google Scholar 

  45. Von Andrian UH, Hasslen SR, Nelson RD, Erlandsen SL, Butcher EC (1995) Cell 82: 989–99.

    PubMed  CAS  Google Scholar 

  46. Patel KD, Nollert MU, McEver RP (1995) J Cell Biol 131: 1893–902.

    PubMed  CAS  Google Scholar 

  47. Moore KL, Patel KD, Bruehl RE, Fugang L, Johnson DA, Lichenstein HS, Cummings RD, Bainton DF, McEver RP (1995) J Cell Biol 128: 661–71.

    PubMed  CAS  Google Scholar 

  48. Patel KD, Moore KL, Nollert MU, McEver RP (1995) J Clin Invest 96: 1887–96.

    PubMed  CAS  Google Scholar 

  49. Norman KE, Moore KL, McEver RP, Ley K (1995) Blood 86: 4417–21.

    PubMed  CAS  Google Scholar 

  50. Guyer DA, Moore KL, Lynam E, Schammel CMG, Rogelj S, McEver RP, Sklar LA (1996) Blood 88: 2415–21.

    PubMed  CAS  Google Scholar 

  51. Li F, Erickson HP, James JA, Moore KL, Cummings RD, McEver RP (1996) J Biol Chem 271: 6342–48.

    PubMed  CAS  Google Scholar 

  52. Weller A, Isenmann S, Vestweber D (1992) J Biol Chem 267: 15176–83.

    PubMed  CAS  Google Scholar 

  53. Sanders WE, Wilson RW, Ballantyne CM, Beaudet AL (1992) Blood 80: 795–800.

    PubMed  CAS  Google Scholar 

  54. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD (1993) Cell 74: 541–54.

    PubMed  CAS  Google Scholar 

  55. Burns SA, DeGuzman BJ, Newburger JW, Mayer JE, Jr, Neufeld EJ, Briscoe DM(1995) J Thorac Cardiovasc Surg 110: 924–33.

    PubMed  CAS  Google Scholar 

  56. Yao L, Pan J. Setiadi H, Patel KD, McEver RP (1996) J Exp Med 184: 81–92.

    PubMed  CAS  Google Scholar 

  57. George JN, Pickett EB, Saucerman S, McEver RP, Kunicki TJ, Kieffer N, Newman PJ (1986) J Clin Invest 78: 340–48.

    PubMed  CAS  Google Scholar 

  58. Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ (1989) J Biol Chem 264: 7768–71.

    PubMed  CAS  Google Scholar 

  59. Kuijpers TW, Raleigh M, Kavanagh T, Janssen H, Calafat J, Roos D, Harlan JM (1994) J Immunol 152: 5060–69.

    PubMed  CAS  Google Scholar 

  60. Setiadi H, Disdier M, Green SA, CanÞeld WM, McEver RP (1995) J Biol Chem 270: 26818–26.

    PubMed  CAS  Google Scholar 

  61. Green SA, Setiadi H, McEver RP, Kelly RB (1994) J Cell Biol 124: 435–48.

    PubMed  CAS  Google Scholar 

  62. Bevilacqua MP, Stengelin S, Gimbrone MA, Jr, Seed B (1989) Science 243: 1160–65.

    PubMed  CAS  Google Scholar 

  63. Smeets EF, de Vries T, Leeuwenberg JFM, Van den Eijnden DH, Buurman WA, Neefjes JJ (1993) Eur J Immunol 23: 147–51.

    PubMed  CAS  Google Scholar 

  64. Subramaniam M, Koedam JA, Wagner DD (1993) Mol Biol Cell 4: 791–801.

    PubMed  CAS  Google Scholar 

  65. Disdier M, Morrissey JH, Fugate RD, Bainton DF, McEver RP (1992) Mol Biol Cell 3: 309–21.

    PubMed  CAS  Google Scholar 

  66. Norcott JP, Solari R, Cutler DF (1996) J Cell Biol 134: 1229–40.

    PubMed  CAS  Google Scholar 

  67. Granger DN, Kubes P (1994) J Leukocyte Biol 55: 662–75.

    PubMed  CAS  Google Scholar 

  68. Ley K, Tedder TF (1995) J Immunol 155: 525–28.

    PubMed  CAS  Google Scholar 

  69. Etzioni A, Frydman M, Pollack S, Avidor I, Phillips ML, Paulson JC, Gershoni-Baruch R (1992) N Engl J Med 327: 1789–92.

    PubMed  CAS  Google Scholar 

  70. Von Andrian UH, Berger EM, Ramezani L, Chambers JD, Ochs HD, Harlan JM, Paulson JC, Etzioni A, Arfors K-E (1993) J Clin Invest 91: 2893–97.

    PubMed  CAS  Google Scholar 

  71. Philips ML, Schwartz BR, Etzioni A, Bayer R, Ochs HD, Paulson JC, Harlan JM (1995) J Clin Invest 96: 2898–906.

    Google Scholar 

  72. Labow MA, Norton CR, Rumberger JM, Lombard-Gillooly KM, Shuster DJ, Hubbard J, Bertko R, Knaack PA, Terry RW, Harbison ML, Kontgen F, Stewart CL, McIntyre KW, Will PC, Burns KD, Wolitzky BA (1994) Immunity 1: 709–20.

    PubMed  CAS  Google Scholar 

  73. Arbones ML, Ord DC, Ley K, Ratech H, Maynard-Curry C, Otten G, Capon DJ, Tedder TF (1994) Immunity 1: 247–60.

    PubMed  CAS  Google Scholar 

  74. Ley K, Bullard DC, Arboneés ML, Bosse R, Vestweber D, Tedder TF, Beaudet AL (1995) J Exp Med 181: 669–75.

    PubMed  CAS  Google Scholar 

  75. Ley K, Zakrzewicz A, Hanski C, Stoolman LM, Kansas GS (1995) Blood 85: 3727–35.

    PubMed  CAS  Google Scholar 

  76. Subramaniam M, Saffaripour S, Watson SR, Mayadas TN, Hynes RO, Wagner DD (1995) J Exp Med 181: 2277–82.

    PubMed  CAS  Google Scholar 

  77. Tedder TF, Steeber DA, Pizcueta P (1995) J Exp Med 181: 2259–64.

    PubMed  CAS  Google Scholar 

  78. Bullard DC, Kunkel EJ, Kubo H, Hicks MJ, Lorenzo I, Doyle NA, Doerschuk CM, Ley K, Beaudet AL (1996) J Exp Med 183: 2329–36.

    PubMed  CAS  Google Scholar 

  79. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD (1996) Cell 84: 563–74.

    PubMed  CAS  Google Scholar 

  80. Zannettino ACW, Berndt MC, Butcher C, Butcher EC, Vadas MA, Simmons PJ (1995) Blood 85: 3466–77.

    PubMed  CAS  Google Scholar 

  81. Dercksen MW, Weimar IS, Richel DJ, Breton-Gorius J, Vainchenker W, Slaper-Cortenbach ICM, Pinedo HM, von dem Borne AEGKr, Gerritsen WR, Van der Schoot CE (1995) Blood 86: 3771–82.

    PubMed  CAS  Google Scholar 

  82. Laszik Z, Jansen PJ, Cummings RD, Tedder TF, McEver RP, Moore KL (1996) Blood 88: 3010–21.

    PubMed  CAS  Google Scholar 

  83. Oxley SM, Sackstein R (1994) Blood 84: 3299–306.

    PubMed  CAS  Google Scholar 

  84. Spertini O, Cordey A-S, Monai N, Giuffre L, Schapira M (1996) J Cell Biol 135: 523–31.

    PubMed  CAS  Google Scholar 

  85. Nguyen M, Strubel NA, Bischoff J (1993) 365: 267–69.

  86. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ (1995) Nature 376: 517–19.

    PubMed  CAS  Google Scholar 

  87. Albelda SM, Smith CW, Ward PA (1994) FASEB J 8: 504–12.

    PubMed  CAS  Google Scholar 

  88. Sharar SR, Winn RK, Harlan JM (1995) Springer Semin Immunopathol 16: 359–78.

    PubMed  CAS  Google Scholar 

  89. Hattori R, Hamilton KK, McEver RP, Sims PJ (1989) J Biol Chem 264: 9053–60.

    PubMed  CAS  Google Scholar 

  90. Patel KD, Zimmerman GA, Prescott SM, McEver RP, McIntyre TM (1991) J Cell Biol 112: 749–59.

    PubMed  CAS  Google Scholar 

  91. Foreman KE, Vaporciyan AA, Bonish BK, Jones ML, Johnson KJ, Glovsky MM, Eddy SM, Ward PA (1994) J Clin Invest 94: 1147–55.

    PubMed  CAS  Google Scholar 

  92. Vischer UM, Jornot L, Wollheim CB, Theler J-M (1995) Blood 85: 3164–72.

    PubMed  CAS  Google Scholar 

  93. Murohara T, Parkinson SJ, Waldman SA, Lefer AM (1995) Arterioscler Thromb Vasc Biol 15: 2068–75.

    PubMed  CAS  Google Scholar 

  94. Rainger GE, Fisher A, Shearman C, Nash GB (1995) Am J Physiol Heart Circ Physiol 269: H1398–406.

    CAS  Google Scholar 

  95. Pinsky DJ, Naka Y, Liao H, Oz MC, Wagner DD, Mayadas TN, Johnson RC, Hynes RO, Heath M, Lawson CA, Stern DM (1996) J Clin Invest 97: 493–500.

    PubMed  CAS  Google Scholar 

  96. Winn RK, Liggitt D, Vedder NB, Paulson JC, Harlan JM (1993) J Clin Invest 92: 2042–47.

    PubMed  CAS  Google Scholar 

  97. Weyrich AS, Buerke M, Albertine KH, Lefer AM (1995) J Leukocyte Biol 57: 45–55.

    PubMed  CAS  Google Scholar 

  98. Okada Y, Copeland BR, Mori E, Tung M-M, Thomas WS, Del Zoppo GJ (1994) Stroke 25: 202–10.

    PubMed  CAS  Google Scholar 

  99. Weyrich AS, Ma X, Lefer DJ, Albertine KH, Lefer AM (1993) J Clin Invest 91: 2620–29.

    PubMed  CAS  Google Scholar 

  100. Davenpeck KL, Gauthier TW, A lbertine KH, Lefer AM (1994) Am J Physiol Heart Circ Physiol 267: H622–30.

    CAS  Google Scholar 

  101. Mulligan MS, Paulson JC, De Frees S, Zheng Z-L, Lowe JB, Ward PA (1993) Nature 364: 149–51.

    PubMed  CAS  Google Scholar 

  102. Gauthier TW, Davenpeck KL, Lefer AM (1994) Am J Physiol Gastrointest Liver Physiol 267: G562–68.

    CAS  Google Scholar 

  103. Chen LY, Nichols WW, Hendricks JB, Yang BC, Mehta JL (1994) Cardiovasc Res 28: 1414–22.

    PubMed  CAS  Google Scholar 

  104. Winn RK, Paulson JC, Harlan JM (1994) Am J Physiol Heart Circ Physiol 267: H2391–97.

    CAS  Google Scholar 

  105. Lee WP, Gribling P, De Guzman L, Ehsani N, Watson SR (1995) Surgery 117: 458–65.

    PubMed  CAS  Google Scholar 

  106. Lefer DJ, Flynn DM, Buda AJ (1996) Am J Physiol 39: H88–H98.

    Google Scholar 

  107. Coughlan AF, Hau H, Dunlop LC, Berndt MC, Hancock WW (1994) J Exp Med 179: 329–34.

    PubMed  CAS  Google Scholar 

  108. Mulligan MS, Polley MJ, Bayer RJ,, Nunn MF, Paulson JC, Ward PA (1992) J Clin Invest 90: 1600–7.

    PubMed  CAS  Google Scholar 

  109. Ma X, Weyrich AS, Lefer DJ, Buerke M, Albertine KH, Kishimoto TK, Lefer AM (1993) Circulation 88: 649–58.

    PubMed  CAS  Google Scholar 

  110. Mihelcic D, Schleiffenbaum B, Tedder TF, Sharar SR, Harlan JM, Winn RK (1994) Blood 84: 2322–28.

    PubMed  CAS  Google Scholar 

  111. Mulligan MS, Miyasaka M, Tamatani T, Jones ML, Ward PA (1994) J Immunol 152: 832–40.

    PubMed  CAS  Google Scholar 

  112. Grober JS, Bowen BL, Ebling H, Athey B, Thompson CB, Fox DA, Stoolman LM (1993) J Clin Invest 91: 2609–19.

    PubMed  CAS  Google Scholar 

  113. Symon FA, Walsh GM, Watson SR, Wardlaw AJ (1994) J Exp Med 180: 371–76.

    PubMed  CAS  Google Scholar 

  114. Johnson-Tidey RR, McGregor JL, Taylor PR, Poston RN (1994) Am J Pathol 144: 952–61.

    PubMed  CAS  Google Scholar 

  115. Lehr H-A, Olofsson AM, C arew TE, Vajkoczy P, Von Andrian UH, Huübner C, Berndt MC, Steinberg D, Messmer K, Arfors KE (1994) Lab Invest 71: 380–86.

    PubMed  CAS  Google Scholar 

  116. Lehr H-A, Frei B, Arfors K-E (1994) Proc Natl Acad Sci USA 91: 7688–92.

    PubMed  CAS  Google Scholar 

  117. Etingin OR, Silverstein RL, Hajjar DP (1992) Proc Natl Acad Sci USA 88: 7200–3.

    Google Scholar 

  118. Palabrica T, Lobb R, Furie BC, Aronovitz M, Benjamin C, Hsu Y-M, Sajer SA, Furie B (1992) Nature 359: 848–51.

    PubMed  CAS  Google Scholar 

  119. Toombs CF, DeGraaf CL, Martin JP, Geng JG, Anderson DC, Shebuski RJ (1995) J Pharmacol Exp Ther 275: 941–49.

    PubMed  CAS  Google Scholar 

  120. Wakefield TW, Strieter RM, Downing LJ, Kadell AM, Wilke CA, Burdick MD, Wrobleski SK, Phillips ML, Paulson JC, Anderson DC, GreenÞeld LJ (1996) J Surg Res 64: 26–31.

    PubMed  CAS  Google Scholar 

  121. Sharar SR, Sasaki SS, Flaherty LC, Paulson JC, Harlan JM, Winn RK (1993) J Immunol 151: 4982–88.

    PubMed  CAS  Google Scholar 

  122. Sharar SR, Chapman NN, Flaherty LC, Harlan JM, Tedder TF, Winn RK (1996) J Immunol 157: 2555–63.

    PubMed  CAS  Google Scholar 

  123. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA (1995) J Cell Biol 128: 1243–53.

    Google Scholar 

  124. Berlin C, Bargatze RF, Campbell JJ, Von Andrian UH, Szabo MC, Hasslen SR, Nelson RD, Berg EL, Erlandsen SL, Butcher EC (1995) Cell 80: 413–22.

    PubMed  CAS  Google Scholar 

  125. Stone JP, Wagner DD (1993) J Clin Invest 92: 804–13.

    PubMed  CAS  Google Scholar 

  126. Majuri M-L, Mattila P, Renkonen R (1992) Biochem Biophys Res Commun 182: 1376–82.

    PubMed  CAS  Google Scholar 

  127. Spertini O, Callegari P, Cordey A-S, Hauert J, Joggi J, Von Fliedner V, Schapira M (1994) Blood 84: 1249–56.

    PubMed  CAS  Google Scholar 

  128. Moore KL, Eaton SF, Lyons DE, Lichenstein HS, Cummings RD, McEver RP (1994) J Biol Chem 269: 23318–27.

    PubMed  CAS  Google Scholar 

  129. Hensley P, McDevitt PJ, Brooks I, Trill JJ, Feild JA, McNulty DE, Connor JR, Griswold DE, Kumar NV, Kopple KD, Carr SA, Dalton BJ, JohansonK (1994) J Biol Chem 269: 23949–58.

    PubMed  CAS  Google Scholar 

  130. Cyster JG, Shotton DM, Williams AF (1991) EMBO J 10: 893–902.

    PubMed  CAS  Google Scholar 

  131. Walcheck B, Watts G, Jutila MA (1993) J Exp Med 178: 853–63.

    PubMed  CAS  Google Scholar 

  132. Lenter M, Levinovitz A, Isenmann S, Vestweber D (1994) J Cell Biol 125: 471–81.

    PubMed  CAS  Google Scholar 

  133. Aigner S, Ruppert M, Hubbe M, Sammar M, Sthoeger Z, Butcher EC, Vestweber D, Altevogt P (1995) Int Immunol 7: 1557–65.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rodger P McEver.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McEver, R.P. Selectin-carbohydrate interactions during inflammation and metastasis. Glycoconj J 14, 585–591 (1997). https://doi.org/10.1023/A:1018584425879

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018584425879

Navigation