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Kmeriol and Other Aromatic Constituents of Kmeria Duperreana

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Abstract

The CHCl3-soluble fraction of a crude extract of Kmeria duperreana exhibited cytotoxic activity when tested in both KB and P388 tumor-cell cultures. Bioassay-directed fractionation led to the isolation of a cytotoxic alkaloid, liriodenine (1). Other constituents obtained from the extract included scopoletin (2), (–)-3,4,5-trimethoxyphenyl β-D-glucopyranoside (3), (+ )-syringaresinol β-D-glucopyranoside (4), and a new phenylpropanol, kmeriol (5), whose chemical structure was established through spectroscopic analysis.

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Authors and Affiliations

  1. Sichuan Institute of Chinese Materia Medica, Chongqing, China

    Xiaoping Dong

  2. Faculty of Pharmaceutical Sciences, Chulongkorn University, Department of Pharmaceutical Botany, Bangkok, Thailand

    Ing-On Mondranondra

  3. Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, P.O. Box 6998, Chicago, Illinois, 60680

    Xiaoping Dong, Ing-On Mondranondra, Chun-tao Che, Harry H. S. Fong & Norman R. Farnsworth

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  1. Xiaoping Dong
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  2. Ing-On Mondranondra
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  3. Chun-tao Che
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  4. Harry H. S. Fong
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  5. Norman R. Farnsworth
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Dong, X., Mondranondra, IO., Che, Ct. et al. Kmeriol and Other Aromatic Constituents of Kmeria Duperreana . Pharm Res 6, 637–640 (1989). https://doi.org/10.1023/A:1015969902200

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