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Control of Locomotor Activity in Humans and Animals in the Absence of Supraspinal Influences

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Abstract

Electrical epidural stimulation of the dorsal surface of the spinal cord at the level of the second lumbar segment induced step-like movements accompanied by the corresponding electromyographic activity in the leg muscles in patients lacking supraspinal influences as a result of vertebral trauma. Triggering of stepping movements was shown to occur with particular stimulation parameters. The results provide evidence that in humans, as in other mammals, the spinal cord contains a network of interneurons acting as generators of stepping movements and producing coordinated patterns of movement activity. Experiments on chronic spinal cats demonstrated the leading role of the propriospinal system of the spinal cord in activating the spinal generators of stepping in response to epidural stimuli.

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Authors and Affiliations

  1. Laboratory for Movement Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia

    Yu. P. Gerasimenko & O. A. Nikitin

  2. Department of Vertebral Surgery, Institute of Phthysiopulmonology, Ministry of Health of the Russian Federation, 32 Politekhnicheskaya Street, 194064, St. Petersburg, Russia

    A. N. Makarovskii

Authors
  1. Yu. P. Gerasimenko
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  2. A. N. Makarovskii
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  3. O. A. Nikitin
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Gerasimenko, Y.P., Makarovskii, A.N. & Nikitin, O.A. Control of Locomotor Activity in Humans and Animals in the Absence of Supraspinal Influences. Neurosci Behav Physiol 32, 417–423 (2002). https://doi.org/10.1023/A:1015836428932

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  • DOI: https://doi.org/10.1023/A:1015836428932

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