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A cohort study of dietary carotenoids and lung cancer risk in women (Canada)

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Abstract

Objective: To investigate the association between dietary carotenoid intake and lung cancer risk in women. Methods: A case–cohort study was undertaken in the Canadian National Breast Screening Study dietary cohort, which consists of 56,837 women who completed a self-administered dietary questionnaire. The cohort was recruited between 1980 and 1985, and during follow-up to the end of 1993 a total of 196 cohort members were diagnosed with incident lung cancer. For analysis, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 155 cases and 5361 non-cases. Results: When compared to those in the lowest quartile level of intake, the adjusted incidence rate ratios (95% confidence intervals) for those in the highest quartile levels of α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein intake were 0.90 (0.51–1.58), 1.40 (0.76–2.59), 0.66 (0.33–1.32), 1.04 (0.61–1.76), and 1.26 (0.70–2.24), respectively; none of the associated tests for trend was statistically significant. Conclusion: These results suggest that there is no association between dietary carotenoid intake and lung cancer risk, at least for the range of intakes observed here.

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Authors and Affiliations

  1. Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    Thomas E. Rohan

  2. Department of Public Health Sciences at the University of Toronto, Toronto, Canada

    Meera Jain & Anthony B. Miller

  3. Ontario Ministry of Health and Long-term Care, Toronto, Canada

    Meera Jain

  4. Division of Epidemiology, School of Public Health, Columbia University, New York, USA

    Geoffrey R. Howe

  5. Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Anthony B. Miller

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  1. Thomas E. Rohan
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  2. Meera Jain
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  4. Anthony B. Miller
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Rohan, T.E., Jain, M., Howe, G.R. et al. A cohort study of dietary carotenoids and lung cancer risk in women (Canada). Cancer Causes Control 13, 231–237 (2002). https://doi.org/10.1023/A:1015048619413

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