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β-Chitin-based wound dressing containing silver sulfurdiazine

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Abstract

Physical and biological properties of some wound dressing materials based on β-chitin were studied. Water vapor transmission rates (WVTR), oxygen permeabilities and biodegradation kinetics were examined for film-type samples. WVTR of samples was in the range 2400–2800 g/m2/day. However, oxygen permeabilities of the samples were relatively low. To improve oxygen permeabilities, porous sponge-type wound dressing materials were prepared. In addition, these sponge-type samples contained antimicrobial agents, silver sulfadiazine (AgSD), in order to prevent bacteria infection on a wound surface. Anti-microbacterial tests on agar plate were carried out to confirm the bactericidal capacity of present materials. These materials impregnating AgSD had the complete bactericidal capacity against pseudomonas aeruginosa up to 7 days. Finally, a wound healing effect of β–chitin-based semi-interpenetrating polymer networks was evaluated from the animal test using the wistar rat in vivo. Histological studies confirm the proliferation of fibroblasts in the wound bed and a distinct reduction in infectious cells.

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Authors and Affiliations

  1. School of Chemical Engineering, College of Engineering, Hanyang University, Seoul, 133-791, Korea

    Young Moo Lee

  2. School of Chemical Engineering, College of Engineering, Hanyang University, Seoul, 133-791, Korea

    Seong Soo Kim

  3. Department of Pathology, College of Medicine, Hanyang University, Seoul, 133-791, Korea

    Moon Hyang Park & Kang Won Song

  4. Department of Chemistry, College of Natural Sciences, Dongguk University, Seoul, 100-715, Korea

    Yong Kiel Sung

  5. Department of Polymer Science, College of Engineering, Kyungpook National University, Taegu, 702-701, Korea

    In Kyu Kang

Authors
  1. Young Moo Lee
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  2. Seong Soo Kim
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  3. Moon Hyang Park
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  4. Kang Won Song
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  5. Yong Kiel Sung
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  6. In Kyu Kang
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Lee, Y.M., Kim, S.S., Park, M.H. et al. β-Chitin-based wound dressing containing silver sulfurdiazine. Journal of Materials Science: Materials in Medicine 11, 817–823 (2000). https://doi.org/10.1023/A:1008961730929

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