Abstract
The prerequisite for glasses and glass-ceramics to bond to living bone is the formation of biologically active bone-like apatite on their surfaces. It has been shown that even a pure silica gel forms the bone-like apatite on its surface in a simulated body fluid. In the present study, pore structure of silica gels prepared by hydrolysis and polycondensation of tetraethoxysilane in an aqueous solution containing polyethylene glycol was modified by 1M HNO3, and 0.1M and 1M NH4OH solution treatments. The three kinds of resultant gels all contained large amounts of silanol groups and trisiloxane rings, but differ greatly in pore structure of nanometre pore size. Irrespective of these differences, all the gels formed the bone-like apatite on their surface in the simulated body fluid. It was speculated that a certain type of structural unit of silanol groups, which is easily formed in the presence of the polyethylene glycol, is effective for the apatite formation. © 1998 Chapman & Hall
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References
L. L. Hench, J. Am. Ceram. Soc. 74(1991) 1487.
T. Kokubo, Biomaterials 12(1991) 155.
L. L. Hench, in “Bioceramics: Material Characteristics versus in vivo Behavior”, Vol. 523, edited by P. Ducheyne and J. E. Lemons (The New York Academy of Science, New York, 1988) p. 54.
K. H. Karlsson, K. Froberg and T. Ringbom, J. Non-Cryst. Solids 112(1989) 69.
C. Ohtsuki, T. Kokubo, K. Takatsuka and T. Yamamuro, J. Ceram. Soc. Jpn 99(1991) 1.
C. Ohtsuki, T. Kokubo and T. Yamamuro, J. Non-Cryst. Solids 143(1992) 84.
P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura and T. Yamamuro, J. Am. Ceram. Soc. 75(1992) 2094.
P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura and T. Yamamuro, J. Appl.Biomater. 4(1993) 221.
P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura and T. Yamamuro, J. Mater. Sci. Mater. Med. 4(1993) 127.
P. Li, T. Kokubo, K. Nakanishi and K. De groot, Biomaterials 14(1993) 963.
S. B. Cho, K. Nakanishi, T. Kokubo, N. Soga, C. Ohtsuki, T. Nakamura, T. Kitsugi and T. Yamamuro, J. Am. Ceram Soc. 78(1995) 1769
T. Kitsugi, T. Nakamura, M. Oka, S. B. Cho, F. Miyaji and T. Kokubo, Calcif. Tiss. Int. 57(1995) 155.
J. H. West and L. L. Hench, in “Bioceramics”, Vol. 5, edited by T. Yamamuro, T. Kokubo and T. Nakamura (Kobunshi Kankokai, Kyoto, 1991) p. 75.
M. M. Pereira, A. E. Clark and L. L. Hench, J. Am. Ceram. Soc. 78(1995) 2463
M. M. Pereira and L. L. Hench, J. Sol-Gel Sci. Technol. 7(1996) 59.
S. B. Cho, K. Nakanishi, T. Kokubo, N. Soga, C. Ohtsuki, and T. Nakamura, J. Biomed. Mater. Res. (Appl. Biometer.) 33(1996) 1451.
T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi and T. Yamamuro, J. Biomed. Mater. Res. 24(1990) 721.
C. Ohtsuki, H. Kushitani, T. Kokubo, S. Kotani and T. Yamamuro, ibid. 25(1991) 1363.
C. Ohtsuki, T. Kokubo, K. Takatsuka and T. Yamamuro, J. Ceram. Soc. Jpn 99(1991) 1.
K. Ohura, T. Yamamuro, T. Nakamura, T. Kokubo, Y. Ebisawa, Y. Kotoura and M. Oka, J. Biomed. Mater. Res. 25(1991) 357.
Y. Ebisawa, T. Kokubo, K. Ohura and T. Yamamuro, J. Mater. Sci. Mater. Med. 1(1990) 239.
T. Kokubo, T. Hayashi, S. Sakka, T. Kitsugi, T. Yamamuro, M. Takagi and T. Shibuya, in “Ceramics in Clinical Applications”, edited by P. Vincenzini (Elsevier, Amsterdam, 1987) p. 175.
S. J. Gregg and K. S. W. Sing, “Adsorption, surface area and porosity” (Academic Press, New York, 1982) p. 1.
A. E. Geissberger and F. L. Galeener, Phys. Rev. B 28(1983) 3266.
T. Kokubo, S. B. Cho, K. Nakanishi, N. Soga, C. Ohtsuki, T. Kitsugi, T. Yamamuro and T. Nakamura, in “Bioceramics”, Vol. 7, edited by O. H. Andersson and A. Yli-Urpo (Butterworth-Heinemann, Oxford, 1994) p. 49.
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Cho, S.B., Miyaji, F., Kokubo, T. et al. Apatite formation on silica gel in simulated body fluid: effects of structural modification with solvent-exchange. Journal of Materials Science: Materials in Medicine 9, 279–284 (1998). https://doi.org/10.1023/A:1008808828567
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DOI: https://doi.org/10.1023/A:1008808828567