Abstract
Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their ability to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q were virtually inactive in this respect. However, all four compounds enhanced the frequency of c-mitoses.
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Turchi, G., Glatt, H., Seidel, A. et al. Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones. Cell Biol Toxicol 13, 155–165 (1997). https://doi.org/10.1023/A:1007302111081
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DOI: https://doi.org/10.1023/A:1007302111081