Abstract
The product, lactic acid, strongly inhibited microbial activity in lactic acid fermentation. The volumetric productivity declined from 1.19 g/l.h with zero lactic acid (control) to only 0.18 g/l.h when lactic acid reached 65 g/l. Lactic acid also inhibited cellulase activity but less severely than the inhibition on microbial activity as lactic acid above 90 g/l was needed for 50% inhibition. A gradual deterioration of the Simultaneous Saccharification and Fermentation (SSF) process occurred with the build-up of lactic acid and the rate-controlling step in SSF shifted from hydrolysis to fermentation as the bioprocess proceeded.
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Iyer, P.V., Lee, Y. Product inhibition in simultaneous saccharification and fermentation of cellulose into lactic acid. Biotechnology Letters 21, 371–373 (1999). https://doi.org/10.1023/A:1005435120978
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DOI: https://doi.org/10.1023/A:1005435120978