Abstract
An outbreak of disease, characterized by depression, anorexia, fever, limb oedema and lymphocytopenia, occurred on a farm for thoroughbreds in India in 1990. Twenty-six of the 88 horses on the farm were affected, predominantly adults. Signs were present in affected horses for 7–10 days, and the outbreak lasted 21 days. Seven of the 26 affected horses were tested for exposure to Getah virus using paired serum samples, acute and convalescent. Four of the 7 horses seroconverted to Getah virus, and the other three showed a 4-fold or greater rise in titre. The clinical and laboratory findings were similar, but not indentical, to those described in natural and experimental infections in Japanese horses. This is the first description of disease caused by Getah virus infection in horses outside Japan. In addition serum samples from 152 horses from 3 regions of India were evaluated for the presence of antibodies to Getah virus. The seroprevalence was found to be 17%, indicating exposure to the virus elsewhere in Indian horses.
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REFERENCES
Asai, T., Shibata, I. and Uruno, K., 1991. Susceptibility of pregnant hamster, guinea pig and rabbit to the transplacental infection of Getah virus. Journal of Veterinary Medical Science, 53, 1109-1111
Bochkova, N.G., Koreshkova, G.V. and Pogodina, V.V., 1981. A study of combined foci of mosquito-transmitted arboviral infections. Voprosy Virusologii, 5, 611-615
Fukunaga, Y., Ando, Y., Kamada, M., Imagawa, H., Wada, R., Kumanomido, T., Akiyama, Y., Watanabe, O., Niwa, K., Takenaga, S., Shibata, M. and Yamamoto, T., 1981. An outbreak of Getah virus infection in horses — clinical and epizootiological aspects at the Miho Training Center in 1978. Bulletin of the Equine Research Institute, 18, 94-102
Goto, H., Sugiura, Y., Ohta, C., Takahashi, K. and Watanabe, H., 1989. Serological evidence of Getah virus infection among horses raised in Hokkaido. Bulletin of the Equine Research Institute, 26, 60-64
Gronwall, R. and Mia, A.S., 1975. Fasting hyperbilirubinemia in horses. American Journal of Digestive Diseases, 17, 473-476
Heo, Y., Park, B.K., An, S.H., Jeon, Y., Yoon, Y.D. and Kim, Y.H., 1987. The survey on horse disease of veterinary importance in the Republic of Korea. Research Report on the Rural Development Administration, 29, 116-120
Hiruma, M., Ide, S., Hohdatsu, T., Yamagishi, H., Tanaka, Y. and Fujisaki, Y., 1990. Polymyositis in mice experimentally innoculated with Getah virus. Japanese Journal of Veterinary Science, 52, 767-772
Imagawa, H., Ando, Y., Kamada, M., Sugiura, T., Kumanomido, T., Fukunaga, Y., Wada, R., Hirasawa, K. and Akiyama, Y., 1981. Sero-epizootiological survey of Getah virus infection in light horses in Japan. Japanese Journal of Veterinary Science, 43, 797-802
Izumida, A., Takuma, H., Inagaki, S., Kubota, M., Hirahara, T., Kodama, K. and Sasaki, N., 1988. Experimental infection of Getah virus in swine. Japanese Journal of Veterinary Science, 50, 679-684
Kamada, M., Ando, Y., Fukunaga, Y., Kumanomido, T., Imagawa, H., Wada, R. and Akiyama, Y., 1980. Equine Getah virus infection: isolation of the virus from racehorses during an enzootic in Japan. American Journal of Tropical Medicine and Hygiene, 29, 984-988
Kamada, M., Ando, Y., Fukunaga, Y., Imagawa, H., Wada, R., Kumanomido, T., Tabuchi, E., Hirasawa, K. and Akiyama, Y., 1981. Studies on Getah virus-pathogenicity of the virus for horses. Bulletin of the Equine Research Institute, 18, 84-93
Kamada, M., Kumanomido, T., Wada, R., Fukunaga, Y., Imagawa, H. and Sugiura, T., 1991a. Intranasal infection of Getah virus in experimental horse. Journal of Veterinary Medicine and Science, 53, 855-858
Kamada, M., Wada, R., Kumanomido, T., Imagawa, H., Sugiura, T. and Fukunaga, Y., 1991b. Effect of viral innoculum size on appearance of clinical signs in equine Getah virus infection. Journal of Veterinary Medicine and Science, 53, 803-806
Kanamitsu, M., Tanigachi, K., Urasawa, S., Ogata, T., Wada, Y. and Saroso, J.S., 1979. Geographic distribution of arbovirus antibodies in indigenous human populations in the Indo-Australian archipelago. American Journal of Tropical Medicine and Hygiene, 28, 351-363
Kulkarni, S.M. and Naik, P.S., 1991. Susceptibility studies on Culex tritaeniorhynchus Giles, 1901, to insecticides in the State of Goa. Indian Journal of Medical Research, 93, 179-181
Kulkarni, S.M., Geevarghese, G. and George, P.J., 1992. Susceptibility of five species of Japanese encephalitis vectors to insecticides from Kolar district, Kamataka. Indian Journal of Medical Research, 95, 247-300
Kumanomido, T., Fukunaga, Y., Kamada, M., Imagawa, H., Ando, Y., Wada, R., Nitta, M. and Akiyama, Y., 1986. Getah virus isolations from mosquitoes collected at two horse habitations in the western areas of Japan. Japanese Journal of Veterinary Science, 48, 1191-1197
Kumanomido, T., Kamada, M., Wada, R., Kenemaru, T., Sugiura, T. and Akiyama, Y., 1988a. Pathogenicity for horses of original Sagiyama virus, a member of the Getah virus group. Veterinary Microbiology, 17, 367-373
Kumanomido, T., Wada, R., Kanemaru, T., Kamada, M., Hirasawa, K. and Akiyama, Y., 1988b. Clinical and virological observations on swine experimentally infected with Getah virus. Veterinary Microbiology, 16, 295-301
Kumanomido, T., Wada, R., Kanemaru, T., Kamada, M., Akiyama, Y. and Matumoto, M., 1988c. Transplacental infection in mice inoculated with Getah virus. Veterinary Microbiology, 16, 129-136
Ksiazek, T.G., Trosper, J.H., Cross, J.H. and Basaca-Sevilla, V., 1981. Isolation of Getah virus from Nueva Ecija Province, Republic of the Philippines. Transactions of the Royal Society of Tropical Medicine and Hygiene, 75, 312-313
Leake, C.J., Ussery, M.A., Nisalak, A., Hoke, C.H., Andre, R.G. and Burke, D.S., 1986. Virus isolations from mosquitoes collected during the 1982 Japanese encephalitis epidemic in northern Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 831-837
Li, X.D., Qui, F.X., Yang, H., Rao, Y.N. and Calisher, C.H., 1992. Isolation of Getah virus from mosquitoes collected on Hainan Island, China, and results of a serosurvey. S.E. Asian Journal of Tropical Medicine and Public Health, 23, 730-734
Lvov, S.D., Gromasheosky, V.L., Andreev, V.P., Skvortsova, T.M., Kondrashina, N.Cr., Morozova, T.N., Avershin, A.D., Aristova, V.A., Dmitriev, G.A., Kandaurov, Y.K., Kuznetsov, A.A., Galkina, I.V., Yamnikova, S.S. and Shchipanova, M.V., 1990. Natural foci of arboviruses in far northern latitudes of Eurasia. Archives of Virology, (Suppl. 1), 267-275
Marchette, N.J., Reednick, A., Garcia, R. and MacVean, D.W., 1978. Alphaviruses in penninsular Malaysia. 1. Virus isolations and animal serology. S.E. Asian Journal of Tropical Medicine and Public Health, 9, 317-329
Matsamura, A., Goto, H., Shimizu, K., Ando, Y., Imagawa, H., Sugiura, T., Akiyama, Y. and Taga, Y., 1981. Prevalence of antibodies against Getah virus in horses raised in Hokkaido. Japanese Journal of Veterinary Science, 43, 783-786
Matsamura, A., Goto, H., Shimizu, K., Sugiura, T., Ando, Y., Kumanomido, T., Hirasawa, K. and Akiyama, Y., 1982. Prevalence and distribution of antibodies to Getah and Japanese encephalitis viruses in horses raised in Hokkaido. Japanese Journal of Veterinary Science, 44, 967-970
Mitchell, C.J., Lvov, S.G., Savage, H.M., Calisher, C.H., Smith, G.C., Lvov, D.K. and Gubler, D.J., 1993. Vector and host relationships of California serogroup viruses in western Siberia. American Journal of Tropical Medicine and Hygiene, 49, 53-62
Peiris, J.S., Amerasinghe, P.H., Calisher, C.H., Perera, L.P., Arunagiri, C.K., Munasingha, N.B. and Karunaratne, S.M., 1994. Viruses isolated from mosquitoes in Sri Lanka. American Journal of Tropical Medicine and Hygiene, 51, 154-161
Senne, D.A., Pearson, J.E. and Carbrey, E.A., 1985. Equine viral arteritis: a standard procedure for the virus neutralization test and comparison of results of a proficiency test performed at five laboratories. Proceedings of the U.S. Animal Health Association, 29-34
Sentsui, H. and Kono, Y., 1980a. An epidemic of Getah virus infection among racehorses: isolation of the virus. Research in Veterinary Science, 29, 57-61
Sentsui, H. and Kono, Y., 1980b. Survey of antibody to Getah virus in horses in Japan. National Institute of Animal Health Quarterly, 20, 39-43
Sentsui, H. and Kono, Y., 1981. Pathogenicity of Getah virus for mice. National Institute of Animal Health Quarterly, 21, 7-13
Sentsui, H. and Kono, Y., 1985. Reappearance of Getah virus infection among horses in Japan. Japanese Journal of Veterinary Science, 47, 333-335
Shibata, I., Hatano, Y., Nishimura, M., Suzuki, Cr. and Inaba, Y., 1991. Isolation of Getah virus from dead fetuses extracted from a naturally infected sow in Japan. Veterinary Microbiology, 27, 385-391
Shortridge, K.F., Mason, D.K., Watkins, K.L. and Aaskov, J.G., 1994. Serological evidence for the transmission of Getah virus in Hong Kong. Veterinary Record, 134, 527-528
Simpson, D.I., Smith, C.E., Marshall, T.F., Platt, G.S., Way, H.J., Bowen, E.T., Bright, W.F., Day, J., McMahon, D.A., Hill, M.N., Bendell, P.J. and Heathcote, O.H., 1976. Arbovirus infection in Sarawak: the role of the domestic pig. Transactions of the Royal Society of Tropical Medicine and Hygiene, 70, 66-72
Spradbrow, P.B., 1972. A survey for arboviruses antibodies in pigs and sheep in Queensland. Australian Veterinary Journal, 48, 402-407
Sugiura, T., Ando, Y., Imagawa, H., Kumanomido, T., Fukunaga, Y., Kamada, M., Wada, R., Hirasawa, K. and Akiyama, Y., 1981. An epizootiological study of Getah virus among light horses in Japan in 1979. Bulletin of the Equine Research Institute, 18, 103-109
Tesh, R.B., Gajdusek, D.C., Garruto, R.M., Cross, J.H. and Rosen, L., 1975. The distribution and prevalence of group A arbovirus neutralizing antibodies among human populations in southeast Asia and the Pacific Islands. American Journal of Tropical Medicine and Hygiene, 24, 664-675
Timoney, P.J. and McCollum, W.H., 1993. Equine viral arteritis. Veterinary Clinics of North America Equine Practice, 9, 295-309
Uppall, P.K., Prasad, J. and Yadav, M.P., 1989. Getah virus infection: a threat to Indian horses. Centaur, 5, 63-64
Wada, R., Kamada, M., Fukunaga, Y., Ando, Y., Kumanomido, T., Imagawa, H. and Akiyama, Y., 1982. Equine Getah virus infection: pathological studies in horses experimentally infected with the MI-110 strain. Japanese Journal of Veterinary Science, 44, 411-418
Yago, K., Hagiwara, S., Kawamura, H. and Narita, M., 1987. A fatal case in newborn piglets with Getah virus infection: isolation of the virus. Japanese Journal of Veterinary Science, 49, 989-994
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Brown, C., Timoney, P. Getah virus infection of Indian horses. Tropical Animal Health and Production 30, 241–252 (1998). https://doi.org/10.1023/A:1005079229232
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DOI: https://doi.org/10.1023/A:1005079229232