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Mechanisms of Pefloxacin-Induced Pain

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Abstract

In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late component of nociceptive flexor reflex. Intrathecal application of pefloxacin in a dose of 20 μg provoked allodynia, while the higher dose of 400 μg induced behavioral pattern characteristic of central pain syndrome. It was hypothesized that pain induced by pefloxacin results from disturbances in GABAergic inhibition in the central subdivisions of the nociceptive system.

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REFERENCES

  1. G. N. Kryzhanovskii, Zh. Nevropatol. Psikhiatr., 99, No. 12, 4-7 (1999).

    Google Scholar 

  2. G. N. Kryzhanovskii, V. K. Reshetnyak, V. A. Zinkevich, et al., Byull. Eksp. Biol. Med., 122, No. 9, 258-261 (1996).

    Google Scholar 

  3. M. L. Kukushkin and S. I. Igon'kina, Ibid., 135, No. 6, 647-651 (2003).

    Google Scholar 

  4. E. R. Padeiskaya and V. P. Yakovlev, Antimicrobial Agents of Fluoroquinolone Family in Clinical Practice [in Russian], Moscow (1998).

  5. W. Christ and B. Esch, Inf. Dis. Clin. Pract., 3, 168-176 (1994).

    Google Scholar 

  6. J. S. Cohen, Ann. Pharmacother., 35, 1540-1547 (2001).

    Google Scholar 

  7. J. M. Domagala, J. Antimicrob. Chemother., 33, 685-708 (1994).

    Google Scholar 

  8. H. L. Du Pont, Clin. Drug Invest., 11, Suppl. 2, 25-29 (1996).

    Google Scholar 

  9. H. Fukuda and Y. Kawamura, Jpn. J. Antibiot., 55, No. 3, 270-280 (2002).

    Google Scholar 

  10. D. C. Hooper and J. S. Wolfson, in: Quinolone Antimicrobial Agents, Eds. D. C. Hooper et al., Washington (1993), pp. 482-512.

  11. D. Le Bars, M. Gozariu, and S. W. Cadden, Pharmacol. Rev., 53, 597-652 (2001).

    Google Scholar 

  12. P. S. Lietman, Drugs, 49, Suppl. 2, 159-163 (1995).

    Google Scholar 

  13. N. Rosentiel and D. Adam, DrugsIbid., 47, 872-901 (1994).

    Google Scholar 

  14. A. Tripathi, S. I. Chen, and S. O'Sullivan, Arch. Ophtalmol., 120, 665-666 (2002).

    Google Scholar 

  15. T. L. Yaksh, Pain., 37, 111-123 (1989).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory of Pathophysiology of Pain, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    M. L. Kukushkin, S. I. Igonkina & T. A. Guskova

Authors
  1. M. L. Kukushkin
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  2. S. I. Igonkina
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  3. T. A. Guskova
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Kukushkin, M.L., Igonkina, S.I. & Guskova, T.A. Mechanisms of Pefloxacin-Induced Pain. Bulletin of Experimental Biology and Medicine 137, 336–338 (2004). https://doi.org/10.1023/B:BEBM.0000035122.45148.93

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  • DOI: https://doi.org/10.1023/B:BEBM.0000035122.45148.93

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