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Induced pluripotent stem cells – alchemist's tale or clinical reality?

Published online by Cambridge University Press:  13 August 2010

S. Tamir Rashid  and
Ludovic Vallier
S. Tamir Rashid
Affiliation:
Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK. Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK.
Ludovic Vallier*
Affiliation:
Laboratory for Regenerative Medicine, University of Cambridge, Cambridge, UK.
*
*Corresponding author: Ludovic Vallier, Laboratory for Regenerative Medicine, University of Cambridge, West Forvie Building, Robinson Way, Cambridge, CB2 0SZ, UK. E-mail: lv225@cam.ac.uk
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Abstract

Following Shinya Yamanaka's first report describing the reprogramming of fibroblasts into stem cells over three years ago, some sceptics initially drew analogies between this new field of research and the quasi-mystical practice of ‘alchemy’. Unlike the alchemist, however, stem cell researchers have rigorously tested and repeated experiments, proving their very own brand of cellular ‘alchemy’ to be a reality, with potentially massive implications for the study of human biology and clinical medicine. These investigations have resulted in an explosion of related publications and initiated the field of stem cell research known as ‘induced pluripotency’. In this review, we give an account of the historical development, current technologies and potential clinical applications of induced pluripotency and conclude with a perspective on the possible future directions for this dynamic field.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 12 , January 2010 , e25
Copyright
Copyright © Cambridge University Press 2010

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References

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Further reading resources and contacts

International society for stem cell research:

Saha, K. and Jaenisch, R. (2009) Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 5, 584-595CrossRefGoogle ScholarPubMed
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