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Mechanisms of Brain Damage in Twins

Published online by Cambridge University Press:  18 September 2015

Margaret G. Norman
Margaret G. Norman*
Affiliation:
Department of Pathology, Vancouver General Hospital and University of British Columbia
*
Children’s Hospital, 4480 Oak Street, Vancouver, B.C. V6H 3V4 Canada
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The brains of 18 twins dying in the perinatal period showed a variety of lesions. Eleven had subependymal cell plate hemorrhage which had ruptured into the lateral ventricles in five. Five had periventricular damage. Three had anoxic neuronal damage. One acardiac monster had bilateral cerebral infarction. One pair had unequal sized brains, probably due to unequal intrauterine nutrition. Twins have a high perinatal mortality and morbidity; as well, intrauterine events may alter brain growth and development in each twin unequally, so they are an imperfect model to study the effect of genes and environment on intelligence.

Type
Hypothesis
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 3 , August 1982 , pp. 339 - 344
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

Armstrong, D., Norman, M.G., (1974) Periventricular leukomalacia in neonates: complications and sequelae. Arch. Dis. Child. 49, 367–375.CrossRefGoogle Scholar
Banker, B.Q., Larroche, J.C. (1962) Periventricular leukomalacia of infancy. Arch. Neurol. 7, 32–56.CrossRefGoogle ScholarPubMed
Barghava, I., Chakravarty, A. (1975) Vascular anastamoses in twin placentae and their recognition. Acta Anat. 93, 471–480.CrossRefGoogle Scholar
Benirschke, K. (1961) Twin placenta in perinatal mortality. N.Y. State J. Med. 61, 1499–1508.Google Scholar
Benirschke, K., Kim, C.K. (1973) Multiple pregnancy. N. Engl. J. Med. 288, 1276–1284.CrossRefGoogle ScholarPubMed
Carakushansky, G., Berthier, C. (1976) The de Lange syndrome in one of twins. J. Med. Genet. 13, 404–406.CrossRefGoogle Scholar
Caviness, V.S. Jr., Evrard, P., Lyon, G. (1978) Radial neuronal assemblies, ectopia and necrosis of developing cortex: a case analysis. Acta Neuropathol. 41, 67–79.CrossRefGoogle ScholarPubMed
Chandra, P., Harilal, K.T. (1978) Pleural births mortality and morbidity. Prog. Clin. Biol. Res. 24B, 109–114.Google Scholar
Corey, L.A., Nance, W.E., Kang, K.W., Christian, J.C. (1979) Effects of type of placentation on birthweight and its variability in monozygotic and dizygotic twins. Acta Geneticae Medicae et Gemel-lologiae, 28, 44–50.Google ScholarPubMed
Derueck, J., Chatta, A.S., Richardson, E.P. Jr. (1972) Pathogenesis and evolution of periventricular leukomalacia in infancy. Arch. Neurol. 27: 229–236.CrossRefGoogle Scholar
Durkin, M.V., Kaveggia, E.G., Pendleton, E., Neuhaüser, G., Opitz, J.M. (1976) Analysis of etiologic factors in cerebral palsy with severe mental retardation. Eur. J. Pediatr. 123, 67–81.CrossRefGoogle ScholarPubMed
Editorial, Br. Med. J. (1977) Preventing prematurity in twins. 1, 1618.Google Scholar
Ferrer, I., Navarro, C. (1978) Multicystic encephalomalacia of infancy. J. Neurol. Sci. 38, 179–189.CrossRefGoogle ScholarPubMed
Friede, R.L. (1975) Developmental Neuropathology. New York, Vienna, Springer-Verlag. pp. 102–122.Google Scholar
Hill, A., Volpe, J.J. (1981) Seizures, hypoxic-ischemic brain injury and intraventricular hemorrhage in the newborn. Ann. Neurol. 10: 109–121.CrossRefGoogle ScholarPubMed
Ho, S.K., Wu, P.Y.K. (1975) Perinatal factors and neonatal morbidity in twin pregnancy. Am. J. Obstet. Gynecol. 122, 979–987.CrossRefGoogle ScholarPubMed
Hoyme, H.E., Higginbottom, M.C., Jones, K.L. (1981) Vascular etiology of disruptive structural defects in monozygotic twins. Pediatrics 67, 288–291.CrossRefGoogle ScholarPubMed
Kaplan, C, Benirschke, K. (1979) The acardiac anomaly: New case reports and current status. Acta Geneticae Medicae Gemellol. 28:51–59.Google ScholarPubMed
Kauppila, A., Jouppilla, P., Koivisto, M., Moilanen, I., Ylikorkala, O. (1975) Twin pregnancy: a clinical study of 335 cases. Acta. Obstet. Gynecol. Scand. (Suppl.) 44, 5–12.Google ScholarPubMed
Koivisto, M., Jouppila, P., Kauppila, A., Moilanen, I., Ylikorkala, O. (1975) Twin pregnancy: Neonatal morbidity and mortality. Acta. Obstet. Gynecol. Scand. (Suppl.) 44, 21–29.CrossRefGoogle ScholarPubMed
Lazzarra, A., Ahmann, P., Dykes, F., Brann, A.W. Jr., Schwartz, J. (1980) Clinical predictability of intraventricular hemorrhage in preterm infants. Pediatrics, 65, 30–34.CrossRefGoogle Scholar
Leetz, I. (1976) Twin pregnancy as a high risk pregnancy. Acta Genet. Med. Gemellog. 25, 307–310.CrossRefGoogle ScholarPubMed
Leroy, F. (1976) Major fetal hazards in multiple pregnancy. Acta. Genet. Med. Gemellol., 25, 299–306.CrossRefGoogle ScholarPubMed
Medearis, A.L., Jonas, H.S., Stockbauer, J.W., Domke, H.R. (1979) Perinatal deaths in twin pregnancy. Am. J. Obstet. Gynecol. 134, 413–418.CrossRefGoogle ScholarPubMed
Müller-Holve, W., Saling, E., Schwarz, M. (1976) The significance of the time interval in twin delivery. J. Perinat. Med. 4, 100–105.CrossRefGoogle ScholarPubMed
Myrianthopoulos, N.C. (1970) An epidemiological survey of twins in a large, prospectively studied population. Am. J. Hum. Genet. 22, 611–629.Google Scholar
Naeye, R.L. (1965) Organ abnormalities in a human parabiotic syndrome. Am. J. Pathol. 46, 829–842.Google Scholar
Nance, W.E. (1979) The role of twin studies in human quantitative genetics. Prog. Med. Genet. 3, 73–107.Google ScholarPubMed
Norman, M.G. (1978) Perinatal brain damage. Perspect. Pediatr. Pathol. 4, 41–92.Google ScholarPubMed
Norman, M.G. (1980) Bilateral encephaloclastic lesions in a 26 week gestation fetus: effect on neuroblast migration. Can. J. Neurol. Sci. 7, 191–194.CrossRefGoogle Scholar
Pape, K.E., Wigglesworth, J.S. (1979) Hemorrhage, ischemia and the perinatal birth. Clinics in Developmental Medicine 69/70, London, William Heinemann Medical Books, pp. 133–148.Google Scholar
Papile, L.A., Burstein, J., Burstein, R., Koffler, H. (1978) Incidence and evolution of subependymal hemorrhage: a study of infants with birth weights less than 1500 Gm. J. Pediatr. 92, 529–534.CrossRefGoogle Scholar
Pettersson, F., Smedby, B., Lindmark, G. (1976) Outcome of twin birth. Acta Paediatr. Scand. 65, 473–479.CrossRefGoogle ScholarPubMed
Power, W.F. (1973) Twin Pregnancy: Complication and treatment. Obstet. Gynecol. 42, 795–808.Google Scholar
Price, B. (1950) Primary biases in twin studies, a review of prenatal and natal difference-producing factors in monozygotic pairs. Am. J. Hum. Genet. 2, 293–352.Google ScholarPubMed
Price, B. (1978) Bibliography on prenatal and natal influences in twins. Acta Genet. Med. Gemellog. 27, 97–113.CrossRefGoogle ScholarPubMed
Rausen, A.R., Seki, M., Strauss, L. (1966) Twin transfusion syndrome. J. Ped. 66, 613–628.CrossRefGoogle Scholar
Rice, J.E. III, Vannucci, R.C., Brierley, J.B. (1981) The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9, 131–141.CrossRefGoogle ScholarPubMed
Slager, U.T., Anderson, V.M., Handmaker, S.D. (1981) Cephalothoracopagus janiceps malformation: a contribution to the pathogenesis of cerebral malformation. Arch. Neurol. 38, 103–108.CrossRefGoogle Scholar
Smith, J.F., Rodeck, C. (1975) Multiple cystic and focal encephalomalacia in infancy and childhood with brain stem damage. J. Neurol. Sci. 25, 377–388.CrossRefGoogle ScholarPubMed
Záhalková, M. (1978) Perinatal & infant mortality in twins. Prog. Clin. Biol. Res. 24B, 115–120.Google Scholar
Zipursky, A., Desa, D., Hsu, E., Johnston, M., Milner, R. (1978) Clinical and laboratory diagnosis of hemostatic disorders in newborn infants. Am. J. Pediatr. Hematol. Oncol. 1, 217–226.CrossRefGoogle Scholar