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Polymerase chain reaction in the diagnosis of parotid gland tuberculosis

Published online by Cambridge University Press:  29 June 2007

Enis Alpin Güneri ,
Ahmet Ömer İkiz ,
Nese Atabey ,
Özlem İzci  and
Semih Sütay
Enis Alpin Güneri*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Dokuz Eylül University Medical School, Izmir, Turkey
Ahmet Ömer İkiz
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Dokuz Eylül University Medical School, Izmir, Turkey
Nese Atabey
Affiliation:
Department of Medical Biology, Dokuz Eylül University Medical School, Izmir, Turkey
Özlem İzci
Affiliation:
Department of Medical Biology, Dokuz Eylül University Medical School, Izmir, Turkey
Semih Sütay
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Dokuz Eylül University Medical School, Izmir, Turkey
*
Address for correspondence: Dr Enis Alpin Güneri, Mithatpaşa cad. 148/12, 35260 lzmir, Turkey. Fax: 90-232-259 05 41 e-mail: gunerie@cs.med.deu.edu.tr
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Abstract

A parotid gland mass with presenting features of malignancy is a diagnostic and therapeutic challenge. The histological nature of the lesion must be clearly determined before proceeding with facial nerve sacrificing surgery. Although rare, tuberculosis of the parotid gland must be included in the differential diagnosis of a parotid gland mass especially when the social characteristics of the patient suggests a mycobacterial infection. Primary tuberculosis of the parotid gland is generally encountered among populations with a high incidence of pulmonary disease. The difficulty in the differential diagnosis of a parotid gland malignancy may be helped by a high degree of clinical suspicion, since laboratory tests generally do not identify the specific causative organism. This article reports the first case of parotid gland tuberculosis with clinical and radiodiagnostical features simulating malignancy in which the diagnosis was confirmed by the polymerase chain reaction (PCR).

Keywords

TuberculosisParotid glandDiagnosis, differential
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 5 , May 1998 , pp. 494 - 496
Copyright
Copyright © JLO (1984) Limited 1998

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References

Ataman, M., Sözeri, B., Özçelik, T., Gedikoğlu, G. (1992) Tuberculosis of the parotid salivary gland. Auris Nasus Larynx 19: 271–273.CrossRefGoogle ScholarPubMed
Ball, A., Thomas, M. (1997) Clinical examination and differential diagnosis. In Colour Atlas and Text of the Salivary Glands Diseases, Disorders and Surgery. 1st Edition. (de Burgh Norman, J. E., McGurk, M., eds.). Mosby-Wolfe Medical Communications, London, pp 129–138.Google Scholar
Bates, J. H. (1979) Diagnosis of tuberculosis. Chest 76: 757–763.CrossRefGoogle ScholarPubMed
Berk, H., Yazici, M., Atabey, N., Ozdamar, S., Pabuccuoglu, U., Alici, E. (1996) Detection of Mycobacterium tuberculosis in formaldehyde solution-fixed paraffin-embedded tissue by polymerase chain reaction in Pott's disease. Spine 21: 1991–1995.CrossRefGoogle ScholarPubMed
Bhat, N. A., Stansbie, J. M. (1996) Tuberculous parotitis:a case report. Journal of Laryngology and Otology 110: 976–977.CrossRefGoogle ScholarPubMed
Degitz, K. (1996) Detection of mycobacterial DNA in the skin. Etiologic insights and diagnostic perspectives. Archives of Dermatology 132: 71–75.CrossRefGoogle ScholarPubMed
Eisenach, K. D., Cave, M. D., Bates, J. H., Crawford, J. T.. (1989) PCR amplification of mycobacteria by amplification of mycobacterial DNA. Molecular Microbiology 3: 843–849.Google Scholar
Greer, C. E., Peterson, S. L., Kiviat, N. B., Manos, M. M.. (1991) PCR amplification from paraffin-embedded tissues. Effects of fixative and fixation time. American Journal of Clinical Pathology 95: 117–124.CrossRefGoogle ScholarPubMed
O'Connell, J. E., George, M. K., Speculand, B., Pahor, A. L. (1993) Mycobacterial infection of the parotid gland: an unusual cause of parotid swelling. Journal of Laryngology and Otology 107: 561–564.CrossRefGoogle ScholarPubMed
Perosio, P. M., Frank, T. S. (1993) Detection and species identification of mycobacteria in paraffin sections of lung biopsy specimens by polymerase chain reaction. American Journal of Clinical Pathology 100: 643–647.CrossRefGoogle ScholarPubMed
Rowe-Jones, J. M., Vowles, R., Leighton, S. E., Freedman, A. R. (1992) Diffuse tuberculous parotitis. Journal of Laryngology and Otology 106: 1094–1095.CrossRefGoogle ScholarPubMed
Singh, B., Maharaj, T. J. (1992) Tuberculosis of the parotid gland: clinically indistinguishable from a neoplasm. Journal of Laryngology and Otology 106: 929–931.CrossRefGoogle ScholarPubMed
Stanley, R. B., Fernandez, J. A., Peppard, S. B. (1983) Cervicofacial mycobacterial infections presenting as major salivary gland disease. Laryngoscope 93: 1271–1275.CrossRefGoogle ScholarPubMed
Talmi, Y. P., Shem-Tov, Y., Gal, R., Finkelstein, Y.,Zohar, Y. (1990) Tuberculosis of a periglandular lymph node presentingas a parotid tumor. Journal of Otolaryngology 19: 73–75.Google ScholarPubMed
Ubhi, S. S., Neoptolemos, J. P., Watkin, D. F. L. (1988) Incidence and diagnosis of parotid gland tuberculosis in Asians in Leicester. British Journal of Surgery 75: 313.CrossRefGoogle ScholarPubMed