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Association between maternal hypertensive disorders of pregnancy and child neurodevelopment at 3 years of age: a retrospective cohort study

Published online by Cambridge University Press:  18 June 2020

Masahiro Noda ,
Satomi Yoshida ,
Hiroki Mishina ,
Keisuke Matsubayashi  and
Koji Kawakami Open the ORCID record for Koji Kawakami [Opens in a new window]
Masahiro Noda
Affiliation:
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto606-8501, Japan
Satomi Yoshida
Affiliation:
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto606-8501, Japan
Hiroki Mishina
Affiliation:
Child Development Department, Kobe City650-8570, Japan
Keisuke Matsubayashi
Affiliation:
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto606-8501, Japan
Koji Kawakami*
Affiliation:
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto606-8501, Japan
*
Author for correspondence: Koji Kawakami, Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto606-8501, Japan. Email: kawakami.koji.4e@kyoto-u.ac.jp
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Abstract

Hypertensive disorders of pregnancy (HDP) affect up to 10% of women during pregnancy and influence child neurodevelopment, including mental and motor function. We assessed whether HDP, including gestational hypertension, preeclampsia, superimposed preeclampsia, and eclampsia, correlate with motor and mental developmental abnormalities in 3-year-old children, using data obtained between April 2004 and March 2013 through a mandatory population-based health checkup of mothers and children in Kobe city, Japan. The primary outcome was motor and mental developmental abnormalities at 3 years of age; parental-reported questionnaires and physician’s medical examinations were evaluated. The association between maternal HDP and child neurodevelopmental abnormality was evaluated using a logistic regression model. Of the 43,854 participating children, 1120 were born to women with HDP and 42,734 were born to women without HDP. The prevalence of motor developmental abnormality was 1.7% in the exposed group and 0.95% in the control group; the prevalence of mental developmental abnormality was 2.41% in the exposed group and 1.22% in the control group. Children born to mothers with HDP did not have an increased risk of motor developmental abnormality at the age of 3 years [adjusted odds ratio (OR) 1.17, 95% confidence interval 0.72–1.91], but had an increased risk of mental developmental abnormality (adjusted OR 1.80, 95% confidence interval 1.21–2.69). Maternal HDP were associated with mental development abnormality in 3-year-old children. These findings may be clinically relevant; mental abnormality in children born to women with HDP could be detected during early stages, which would facilitate early intervention.

Keywords

Health checkupshypertensive disorder of pregnancyneurodevelopmentretrospective cohort study
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 3 , June 2021 , pp. 428 - 435
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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References

Sotiriadis, A, Hernandez-Andrade, E, da Silva Costa, F, et al. ISUOG Practice Guidelines: role of ultrasound in screening for and follow-up of pre-eclampsia. Ultrasound Obstet Gynecol. 2019; 53(1): 7–22.CrossRefGoogle ScholarPubMed
Duley, L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009; 33(3): 130–137.CrossRefGoogle ScholarPubMed
Practice Bulletin No, ACOG. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol. 2019; 133(1): e1–e25.Google Scholar
McCowan, L, Horgan, RP. Risk factors for small for gestational age infants. Best Pract Res Clin Obstet Gynaecol. 2009; 23(6): 779–793.CrossRefGoogle ScholarPubMed
Sibai, B, Dekker, G, Kupferminc, M. Pre-eclampsia. Lancet 2005; 365(9461): 785–799.CrossRefGoogle ScholarPubMed
Morsing, E, Maršál, K. Pre-eclampsia- an additional risk factor for cognitive impairment at school age after intrauterine growth restriction and very preterm birth. Early Hum Dev. 2014; 90(2): 99–101.CrossRefGoogle ScholarPubMed
Warshafsky, C, Pudwell, J, Walker, M, et al. Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia. BMJ Open. 2016; 6(7): e010884.CrossRefGoogle ScholarPubMed
van Wassenaer, AG, Westera, J, van Schie, PE, et al. Outcome at 4.5 years of children born after expectant management of early-onset hypertensive disorders of pregnancy. Am J Obstet Gynecol. 2011; 204(6): 510.e1–510.e9.CrossRefGoogle ScholarPubMed
Strand, KM, Heimstad, R, Iversen, AC, et al. Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study. BMJ. 2013; 347: f4089.CrossRefGoogle ScholarPubMed
Mann, JR, McDermott, S, Griffith, MI, et al. Uncovering the complex relationship between pre-eclampsia, preterm birth and cerebral palsy. Paediatr Perinat Epidemiol. 2011; 25(2): 100–110.CrossRefGoogle ScholarPubMed
Seidman, DS, Laor, A, Gale, R, et al. Pre-eclampsia and offspring’s blood pressure, cognitive ability and physical development at 17-years-of-age. Br J Obstet Gynaecol. 1991; 98(10): 1009–1014.CrossRefGoogle ScholarPubMed
Leitner, Y, Harel, S, Geva, R, et al. The neurocognitive outcome of IUGR children born to mothers with and without preeclampsia. J Matern Fetal Neonatal Med. 2012; 25(11): 2206–2208.CrossRefGoogle ScholarPubMed
Love, ER, Crum, J, Bhattacharya, S. Independent effects of pregnancy induced hypertension on childhood development: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol. 2012; 165(2): 219–224.CrossRefGoogle ScholarPubMed
Silveira, RC, Procianoy, RS, Koch, MS, et al. Growth and neurodevelopment outcome of very low birth weight infants delivered by preeclamptic mothers. Acta Paediatr. 2007; 96(12): 1738–1742.CrossRefGoogle ScholarPubMed
Wu, CS, Nohr, EA, Bech, BH, et al. Health of children born to mothers who had preeclampsia: a population-based cohort study. Am J Obstet Gynecol. 2009; 201(3): 269.e1–269.e10.CrossRefGoogle ScholarPubMed
Many, A, Fattal, A, Leitner, Y, et al. Neurodevelopmental and cognitive assessment of children born growth restricted to mothers with and without preeclampsia. Hypertens Pregnancy. 2003; 22(1): 25–29.CrossRefGoogle ScholarPubMed
Carlo, WA, Goudar, SS, Pasha, O, et al. Randomized trial of early developmental intervention on outcomes in children after birth asphyxia in developing countries. J Pediatr. 2013; 162(4): 705–712.CrossRefGoogle ScholarPubMed
Zhang, H, Zhang, B, Jia, F, et al. The effects of motor and intellectual functions on the effectiveness of comprehensive rehabilitation in young children with cerebral palsy. J Int Med Res. 2015; 43(1): 125–138.CrossRefGoogle ScholarPubMed
Tanaka, S, Shinzawa, M, Tokumasu, H, et al. Secondhand smoke and incidence of dental caries in deciduous teeth among children in Japan: population based retrospective cohort study. BMJ. 2015; 21; 351: h5397.CrossRefGoogle ScholarPubMed
Takayanagi, K, Iwasaki, S, Yoshinaka, Y. The role of the Maternal and Child Health Handbook system in reducing perinatal mortality in Japan. Clin Perform Qual Health Care 1993; 1(1): 29–33.Google ScholarPubMed
Fujiwara, T, Natsume, K, Okuyama, M, et al. Do home-visit programs for mothers with infants reduce parenting stress and increase social capital in Japan? J Epidemiol Community Health. 2012; 66(12): 1167–1176.CrossRefGoogle ScholarPubMed
Miyaji, NT, Lock, M. Monitoring motherhood: sociocultural and historical aspects of maternal and child health in Japan. Daedalus. 1994; 123(4): 87–112.Google ScholarPubMed
Watanabe, K, Naruse, K, Tanaka, K, et al. Outline of Definition and Classification of “Pregnancy induced Hypertension (PIH)”. Hypertens Res Pregnancy. 2013; 1: 3–4.CrossRefGoogle Scholar
Walker, CK, Krakowiak, P, Baker, A, et al. Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay. JAMA Pediatr. 2015; 169(2): 154–162.CrossRefGoogle ScholarPubMed
Persson, M, Razaz, N, Tedroff, K, et al. Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden. BMJ. 2018; 360: k207.CrossRefGoogle ScholarPubMed
Cheng, SW, Chou, HC, Tsou, KI, et al. Delivery before 32 weeks of gestation for maternal pre-eclampsia: neonatal outcome and 2-year developmental outcome. Early Hum Dev. 2004; 76(1): 39–46.CrossRefGoogle ScholarPubMed
Jarvis, S, Glinianaia, SV, Torrioli, MG, et al. Cerebral palsy and intrauterine growth in single births: European collaborative study. Lancet. 2003; 362(9390): 1106–1111.CrossRefGoogle ScholarPubMed
Duckitt, K, Harrington, D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005; 330(7491): 565.CrossRefGoogle ScholarPubMed
Yeo, KT, Lee, QY, Quek, WS, et al. Trends in Morbidity and Mortality of Extremely Preterm Multiple Gestation Newborns. Pediatrics. 2015; 136(2): 263–271.CrossRefGoogle ScholarPubMed
Ananth, CV, Savitz, DA, Bowes, WA Jr, et al. Influence of hypertensive disorders and cigarette smoking on placental abruption and uterine bleeding during pregnancy. Br J Obstet Gynaecol. 1997; 104(5): 572–578.CrossRefGoogle ScholarPubMed
Iwama, N, Metoki, H, Nishigori, H, et al. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study. Hypertens Res. 2019; 42(1): 85–94.CrossRefGoogle ScholarPubMed
Ip, S, Chung, M, Kulig, J, et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics. 2004; 114(1): e130–e133.CrossRefGoogle ScholarPubMed
Lederer, DJ, Bell, SC, Branson, RD, et al. Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals. Ann Am Thorac Soc. 2019; 16(1): 22–28.CrossRefGoogle ScholarPubMed
Grether, JK, Nelson, KB. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA. 1997; 278(3): 207–211.CrossRefGoogle ScholarPubMed
Roberts, JM, Redman, CW. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 1993; 341(8858): 1447–1451.CrossRefGoogle ScholarPubMed
Burton, GJ, Jauniaux, E. Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig. 2004; 11(6): 342–352.CrossRefGoogle ScholarPubMed
Hirvonen, M, Ojala, R, Korhonen, P, et al. Cerebral palsy among children born moderately and late preterm. Pediatrics. 2014; 134(6): e1584–e1593.CrossRefGoogle ScholarPubMed
Ilekis, JV, Tsilou, E, Fisher, S, et al. Placental origins of adverse pregnancy outcomes: potential molecular targets: an executive workshop summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Am J Obstet Gynecol. 2016; 215: S1–S46.CrossRefGoogle ScholarPubMed
Huppertz, B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension. 2008; 51(4): 970–975.CrossRefGoogle ScholarPubMed
Ilekis, JV, Reddy, UM, Roberts, JM. Preeclampsia--a pressing problem: an executive summary of a National Institute of Child Health and Human Development workshop. Reprod Sci. 2007; 14(6): 508–523.CrossRefGoogle ScholarPubMed
Roberts, JM, Hubel, CA. The two stage model of preeclampsia: variations on the theme. Placenta. 2009; 30(Suppl A): S32–S37.CrossRefGoogle ScholarPubMed
Novak, CM, Ozen, M, Burd, I. Perinatal brain injury: mechanisms, prevention, and outcomes. Clin Perinatol. 2018; 45(2): 357–375.CrossRefGoogle Scholar
Brown, AS, Sourander, A, Hinkka-Yli-Salomäki, S, et al. Elevated maternal C-reactive protein and autism in a national birth cohort. Mol Psychiatry. 2014; 19(2): 259–264.CrossRefGoogle Scholar
Rätsep, MT, Paolozza, A, Hickman, AF, et al. Brain structural and vascular anatomy is altered in offspring of pre-eclamptic pregnancies: a pilot study. Am J Neuroradiol. 2016; 37(5): 939–945.CrossRefGoogle ScholarPubMed
Kronenberg, ME, Raz, S, Sander, CJ. Neurodevelopmental outcome in children born to mothers with hypertension in pregnancy: the significance of suboptimal intrauterine growth. Dev Med Child Neurol. 2006; 48(3): 200–206.CrossRefGoogle ScholarPubMed
Grisaru-Granovsky, S, Halevy, T, Eidelman, A, et al. Hypertensive disorders of pregnancy and the small for gestational age neonate: not a simple relationship. Am J Obstet Gynecol. 2007; 196(4): 335.e1–335.e5.CrossRefGoogle ScholarPubMed
Clayton, PE, Cianfarani, S, Czernichow, P, et al. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab. 2007; 92(3): 804–810.CrossRefGoogle ScholarPubMed
Kallioinen, M, Eadon, H, Murphy, MS, et al. Developmental follow-up of children and young people born preterm: summary of NICE guidance. BMJ. 2017; 358: j3514.CrossRefGoogle Scholar
American Academy of Pediatrics Committee on Fetus and Newborn. Hospital discharge of the high-risk neonate. Pediatrics 2008; 122: 1119–1126.CrossRefGoogle Scholar
Tuovinen, S, Eriksson, JG, Kajantie, E, et al. Maternal hypertensive pregnancy disorders and cognitive functioning of the offspring: a systematic review. J Am Soc Hypertens. 2014; 8(11): 832–47.e1.CrossRefGoogle ScholarPubMed
Kobe City, Demographic. http://www.city.kobe.lg.jp/information/data/statistics/toukei/jinkou/jinkouugoki.html#midashi53863 Google Scholar
Kobe City, Summary of Health Project. http://www.city.kobe.lg.jp/life/health/phc/report/annual/index.html Google Scholar
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