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Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults

Published online by Cambridge University Press:  14 October 2020

Cutter A. Lindbergh Open the ORCID record for Cutter A. Lindbergh [Opens in a new window] ,
Nicole Walker ,
Renaud La Joie Open the ORCID record for Renaud La Joie [Opens in a new window] ,
Sophia Weiner-Light ,
Adam M. Staffaroni ,
Kaitlin B. Casaletto ,
Fanny Elahi ,
Samantha M. Walters ,
Michelle You  and
Devyn Cotter
...Show all authors
Cutter A. Lindbergh*
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Nicole Walker
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Renaud La Joie
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Sophia Weiner-Light
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Adam M. Staffaroni
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Kaitlin B. Casaletto
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Fanny Elahi
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Samantha M. Walters
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Michelle You
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Devyn Cotter
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Breton Asken
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Alexandra C. Apple
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Elena Tsoy
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
John Neuhaus
Affiliation:
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
Corrina Fonseca
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Amy Wolf
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Yann Cobigo
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Howie Rosen
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Joel H. Kramer
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
*
*Correspondence and reprint requests to: Dr. Cutter A. Lindbergh, Memory and Aging Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA94143, USA. E-mail: Cutter.Lindbergh@ucsf.edu
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Abstract

Objective: We evaluated whether memory recall following an extended (1 week) delay predicts cognitive and brain structural trajectories in older adults
Method:

Clinically normal older adults (52–92 years old) were followed longitudinally for up to 8 years after completing a memory paradigm at baseline [Story Recall Test (SRT)] that assessed delayed recall at 30 min and 1 week. Subsets of the cohort underwent neuroimaging (N = 134, mean age = 75) and neuropsychological testing (N = 178–207, mean ages = 74–76) at annual study visits occurring approximately 15–18 months apart. Mixed-effects regression models evaluated if baseline SRT performance predicted longitudinal changes in gray matter volumes and cognitive composite scores, controlling for demographics.

Results:

Worse SRT 1-week recall was associated with more precipitous rates of longitudinal decline in medial temporal lobe volumes (p = .037), episodic memory (p = .003), and executive functioning (p = .011), but not occipital lobe or total gray matter volumes (demonstrating neuroanatomical specificity; p > .58). By contrast, SRT 30-min recall was only associated with longitudinal decline in executive functioning (p = .044).

Conclusions:

Memory paradigms that capture longer-term recall may be particularly sensitive to age-related medial temporal lobe changes and neurodegenerative disease trajectories. (JINS, 2020, xx, xx-xx)

Keywords

Alzheimer’s diseaseCognitive agingEarly diagnosisEpisodic memoryLearningTemporal lobe
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 4 , April 2021 , pp. 382 - 388
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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References

REFERENCES

Angel, L., Bastin, C., Genon, S., Salmon, E., Fay, S., Balteau, E., … Collette, F. (2016). Neural correlates of successful memory retrieval in aging: do executive functioning and task difficulty matter? Brain Research, 1631, 53–71. https://doi.org/10.1016/j.brainres.2015.10.009 CrossRefGoogle ScholarPubMed
Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. NeuroImage, 38(1), 95–113. https://doi.org/10.1016/J.NEUROIMAGE.2007.07.007 CrossRefGoogle ScholarPubMed
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Tredici, K. (2006). Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathologica, 112(4), 389–404. https://doi.org/10.1007/s00401-006-0127-z CrossRefGoogle ScholarPubMed
Butler, C.R., Bhaduri, A., Acosta-Cabronero, J., Nestor, P.J., Kapur, N., Graham, K.S., … Zeman, A.Z. (2009). Transient epileptic amnesia: regional brain atrophy and its relationship to memory deficits. Brain, 132(2), 357–368. https://doi.org/10.1093/brain/awn336 CrossRefGoogle ScholarPubMed
Butler, C.R., Graham, K.S., Hodges, J.R., Kapur, N., Wardlaw, J.M., & Zeman, A.Z.J. (2007). The syndrome of transient epileptic amnesia. Annals of Neurology, 61(6), 587–598. https://doi.org/10.1002/ana.21111 CrossRefGoogle ScholarPubMed
Casaletto, K.B., Marx, G., Dutt, S., Neuhaus, J., Saloner, R., Kritikos, L., … Kramer, J.H. (2017). Is “Learning” episodic memory? Distinct cognitive and neuroanatomic correlates of immediate recall during learning trials in neurologically normal aging and neurodegenerative cohorts. Neuropsychologia, 102, 19–28. https://doi.org/10.1016/J.NEUROPSYCHOLOGIA.2017.05.021 CrossRefGoogle Scholar
Desikan, R.S., Ségonne, F., Fischl, B., Quinn, B.T., Dickerson, B.C., Blacker, D., … Killiany, R.J. (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage, 31(3), 968–980. https://doi.org/10.1016/J.NEUROIMAGE.2006.01.021 CrossRefGoogle ScholarPubMed
Jack, C.R., Bennett, D.A., Blennow, K., Carrillo, M.C., Dunn, B., Haeberlein, S.B., … Silverberg, N. (2018). NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia, 14(4), 535–562. https://doi.org/10.1016/j.jalz.2018.02.018 CrossRefGoogle Scholar
Kerchner, G.A., Racine, C.A., Hale, S., Wilheim, R., Laluz, V., Miller, B.L., & Kramer, J.H. (2012). Cognitive processing speed in older adults: relationship with white matter integrity. PLoS One, 7(11), e50425. https://doi.org/10.1371/journal.pone.0050425 CrossRefGoogle ScholarPubMed
Lezak, M. (1995). Neuropsychological assessment. New York: Oxford University Press.Google Scholar
Lezak, M., Howieson, D., Bigler, E., & Tranel, D. (2012). Neuropsychological assessment (5th ed.). New York: Oxford University Press.Google Scholar
Lindbergh, C.A., Casaletto, K.B., Staffaroni, A.M., Elahi, F., Walters, S.M., You, M., … Kramer, J.H. (2019). Systemic tumor necrosis factor-alpha trajectories relate to brain health in typically aging older adults. The Journals of Gerontology: Series A, 75(8), 1558–1565. https://doi.org/10.1093/gerona/glz209 CrossRefGoogle Scholar
Loewenstein, D.A., Curiel, R.E., Duara, R., & Buschke, H. (2018). Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer’s disease. Assessment, 25(3), 348–359. https://doi.org/10.1177/1073191117691608 CrossRefGoogle ScholarPubMed
Manes, F., Serrano, C., Calcagno, M.L., Cardozo, J., & Hodges, J. (2008). Accelerated forgetting in subjects with memory complaints: a new form of mild cognitive impairment? Journal of Neurology, 255(7), 1067–1070. https://doi.org/10.1007/s00415-008-0850-6 CrossRefGoogle ScholarPubMed
Radulovic, J., Jovasevic, V., & Meyer, M.A. (2017). Neurobiological mechanisms of state-dependent learning. Current Opinion in Neurobiology, 45, 92–98. https://doi.org/10.1016/j.conb.2017.05.013 CrossRefGoogle ScholarPubMed
Saloner, R., Casaletto, K.B., Marx, G., Dutt, S., Vanden Bussche, A.B., You, M., … Kramer, J.H. (2018). Performance on a 1-week delayed recall task is associated with medial temporal lobe structures in neurologically normal older adults. The Clinical Neuropsychologist, 32(3), 456–467. https://doi.org/10.1080/13854046.2017.1370134 CrossRefGoogle ScholarPubMed
Squire, L.R., Genzel, L., Wixted, J.T., & Morris, R.G. (2015). Memory consolidation. Cold Spring Harbor Perspectives in Biology, 7(8), 1–21. https://doi.org/10.1101/cshperspect.a021766 CrossRefGoogle ScholarPubMed
Squire, L.R., Stark, C.E.L., & Clark, R.E. (2004). The medial temporal lobe. Annual Review of Neuroscience, 27(1), 279–306. https://doi.org/10.1146/annurev.neuro.27.070203.144130 CrossRefGoogle ScholarPubMed
Walsh, C.M., Wilkins, S., Bettcher, B.M., Butler, C.R., Miller, B.L., & Kramer, J.H. (2014). Memory consolidation in aging and MCI after 1 week. Neuropsychology, 28(2), 273–280. https://doi.org/10.1037/neu0000013 CrossRefGoogle ScholarPubMed
Weston, P.S.J., Nicholas, J.M., Henley, S.M.D., Liang, Y., Macpherson, K., Donnachie, E., … Fox, N.C. (2018). Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer’s disease: A cross-sectional study. The Lancet Neurology, 17(2), 123. https://doi.org/10.1016/S1474-4422(17)30434-9 CrossRefGoogle ScholarPubMed
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